Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies

scientific article published on 4 October 2010

Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2011/570796
P932PMC publication ID3200006
P698PubMed publication ID22046566
P5875ResearchGate publication ID51761265

P2093author name stringOystein Bruserud
Elisabeth Ersvaer
Håkon Reikvam
Kimberley J Hatfield
P2860cites workPhysical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptorsQ24290323
The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cellsQ24290490
TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasmsQ24320364
Molecular genetic characterization of six recessive viable alleles of the mouse agouti locusQ24533165
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2Q24550771
Direct inhibition of the NOTCH transcription factor complexQ24634015
Therapeutic antibody targeting of individual Notch receptorsQ27660544
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementQ27861120
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regenerationQ28238880
A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic miceQ43457473
Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanismQ43607424
Dendritic cell recovery after allogeneic stem-cell transplantation in acute leukemia: correlations with clinical and transplant characteristicsQ44077298
Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetesQ44625248
Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantationQ44746492
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.Q45154679
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.Q45345853
Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cellsQ45863413
Clinical relevance of NK, NKT, and dendritic cell dose in patients receiving G-CSF-mobilized peripheral blood allogeneic stem cell transplantation.Q46823521
Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryosQ47073951
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cellsQ47619638
Viral disease prevention after hematopoietic cell transplantationQ47627052
Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation.Q51790047
Prognostically useful gene-expression profiles in acute myeloid leukemia.Q51999490
Rapid immunologic reconstitution following transplantation with mobilized peripheral blood stem cells as compared to bone marrow.Q52044336
Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia.Q52587062
Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis.Q52906696
Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.Q52933515
Regulation of mesenchymal stem cell activity by endothelial cells.Q54424874
Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis.Q54442995
NOTCH1 mutations are rare in acute myeloid leukemia.Q54571392
Diverse effects of the Notch ligands Jagged1 and Delta1 on the growth and differentiation of primary acute myeloblastic leukemia cells.Q54668113
Acute lymphoblastic leukaemiaQ56722375
Fungal infection prevention after hematopoietic cell transplantationQ56970496
Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation in multiple myeloma or non-Hodgkin lymphomaQ60976795
Toll-Like Receptors 3 and 4 Are Expressed by Human Bone Marrow-Derived Mesenchymal Stem Cells and Can Inhibit Their T-Cell Modulatory Activity by Impairing Notch SignalingQ61638150
Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cellsQ73399528
Recovery of lymphocyte and dendritic cell subsets after autologous CD34+ cell transplantationQ73934560
Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cellsQ74601849
Autografting of highly purified peripheral blood progenitor cells following myeloablative therapy in patients with lymphoma: a prospective study of the long-term effects on tumor eradication, reconstitution of hematopoiesis and immune recoveryQ78151865
Itch genetically interacts with Notch1 in a mouse autoimmune disease modelQ79344563
Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progressionQ79954750
Kinetics of recovery of dendritic cell subsets after reduced-intensity conditioning allogeneic stem cell transplantation and clinical outcomeQ80138570
Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3Q80465114
Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitisQ80633672
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenanceQ81308407
JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitisQ81464305
Defects in Notch1 upregulation upon activation of T Cells from patients with systemic lupus erythematosus are related to lupus disease activityQ81638108
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cellsQ81974229
Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host diseaseQ82856669
Notch signaling in the immune systemQ82881379
Rapid helper T-cell recovery above 200 x 10 6/l at 3 months correlates to successful transplant outcomes after allogeneic stem cell transplantationQ83339301
Immunological reconstitution after hematopoietic cell transplantation - its relation to the contents of the graftQ94696821
Targeted therapy in acute myeloid leukaemia: current status and future directionsQ94863269
Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21Q95814547
Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activationQ95816367
Non-canonical activation of Notch signaling/target genes in vertebrates.Q37748565
Targeting Notch to target cancer stem cells.Q37763414
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.Q38343552
Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesisQ38352939
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulationQ38511921
Notch2 signaling is required for potent antitumor immunity in vivo.Q39721274
Notch signaling maintains proliferation and survival of the HL60 human promyelocytic leukemia cell line and promotes the phosphorylation of the Rb proteinQ39739099
Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4.Q39758257
DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequencyQ39815141
Notch signaling: a novel regulating differentiation mechanism of human umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells in vitro.Q39885789
Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytesQ39997530
The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cellsQ40162776
Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cellsQ40163161
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias.Q40226175
CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitorsQ40281359
Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cellsQ40769746
Wnt signaling regulates hemopoiesis through stromal cells.Q40794241
Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signalingQ42602502
Notch versus the proteasome: what is the target of gamma-secretase inhibitor-I?Q42957812
Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release.Q43202086
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow nicheQ28505006
RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cellsQ28511728
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specificationQ28587231
A role for Wnt signalling in self-renewal of haematopoietic stem cellsQ28592213
Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemiaQ28646247
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemiaQ29614269
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cellsQ29615006
Osteoblastic cells regulate the haematopoietic stem cell nicheQ29615007
Identification of the haematopoietic stem cell niche and control of the niche sizeQ29615008
Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID miceQ30165266
Cis-interactions between Notch and Delta generate mutually exclusive signalling statesQ30494896
Proteasome inhibition reduces donor-specific antibody levelsQ33383491
Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpuraQ33385380
NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) studyQ33395926
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptorsQ33531734
Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitutionQ33642298
Acute myelogenous leukemia blasts as accessory cells during T lymphocyte activation: possible implications for future therapeutic strategiesQ33713476
Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell functionQ33806045
Cortical neural precursors inhibit their own differentiation via N-cadherin maintenance of beta-catenin signaling.Q33834694
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cellsQ33837223
Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cellsQ34052587
Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cellsQ34052591
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factorsQ34152009
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domainQ34189079
Glycosylation regulates Notch signalling.Q34271410
Hematopoiesis is severely altered in mice with an induced osteoblast deficiencyQ34290169
The nervous system and innate immunity: the neuropeptide connectionQ34420533
Biological treatment in acute myelogenous leukaemia: how should T-cell targeting immunotherapy be combined with intensive chemotherapy?Q34452706
TGFbeta/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding abilityQ34545421
NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesisQ34663148
Notch signaling and the bone marrow hematopoietic stem cell nicheQ34776145
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cellsQ34957840
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaQ34958884
Notch regulates cytolytic effector function in CD8+ T cells.Q35219642
Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantationQ36021089
Immune reconstitution following hematopoietic progenitor cell transplantation: challenges for the futureQ36090218
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.Q36141686
The bone marrow vascular niche: home of HSC differentiation and mobilizationQ36262585
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cellsQ36369337
Use of systemic proteasome inhibition as an immune-modulating agent in diseaseQ36754730
Autoimmunity following haematopoietic stem-cell transplantationQ36797795
Immune reconstitution after allogeneic stem cell transplantation with reduced-intensity conditioning regimensQ36831660
Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cellsQ36843721
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisionsQ36905544
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.Q36946535
Signaling pathways governing stem-cell fateQ36959565
Immunomodulation by mesenchymal stem cells and clinical experienceQ36975987
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cellsQ37029646
Dimorphic effects of Notch signaling in bone homeostasis.Q37165102
Chronic GVHD as an autoimmune diseaseQ37173483
Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes.Q37215630
Reconstitution of the immune system after hematopoietic stem cell transplantation in humans.Q37307638
Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition.Q37338140
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiationQ37339719
Transmission and expansion of HOXB4-induced leukemia in two immunosuppressed dogs: implications for a new canine leukemia modelQ37357517
The different faces of Notch in T-helper-cell differentiationQ37376021
FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML.Q37495206
Mesenchymal stem cells for treatment and prevention of graft-versus-host disease after allogeneic hematopoietic cell transplantationQ37509139
Proteasome inhibition for antibody-mediated rejectionQ37577254
Complexity of CEBPA dysregulation in human acute myeloid leukemiaQ37586686
Notch signaling in the hematopoietic systemQ37594765
Acute graft-versus-host disease: new treatment strategiesQ37610714
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiationQ37620912
Wnt signaling in hematopoiesis: crucial factors for self-renewal, proliferation, and cell fate decisionsQ37673086
Nuclear factor-kappaB signaling: a contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemiaQ37688185
Novel roles for Notch, Wnt and Hedgehog in hematopoesis derived from human pluripotent stem cellsQ37718709
The chemokine system in experimental and clinical hematologyQ37724710
CXCR4 in clinical hematologyQ37732036
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)570796
P577publication date2010-10-04
P1433published inBone Marrow ResearchQ26842195
P1476titleFuture perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies
P478volume2011