DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation

scientific article published on July 13, 2011

DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBAMCR.2011.06.023
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0167488911001893?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0167488911001893?httpAccept=text/xml
https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/148020/1/j.bbamcr.2011.06.023.pdf
P698PubMed publication ID21777625
P5875ResearchGate publication ID51510127

P2093author name stringEisuke Nishida
Yoshihiko Miyata
P2860cites workA zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expressionQ21284144
Molecular cloning and characterization of a novel member of the MAP kinase superfamilyQ22010433
Phosphorylation of Ser640 in Muscle Glycogen Synthase by DYRK Family Protein KinasesQ24298852
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1Q24301361
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functionsQ24302518
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFATQ24306261
The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animalsQ24311764
Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteinsQ37404795
DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmineQ39915098
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer diseaseQ40074162
Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndromeQ40089393
The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancerQ40099149
CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.Q40763457
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.Q42826326
Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formationQ43268600
Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamilyQ43559891
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.Q43736456
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina developmentQ43971025
DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassemblyQ44473703
Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunctionQ47232491
DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defectsQ48664609
The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat proteinQ52175870
Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinasesQ24316021
Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblastsQ24532054
The zebrafish dyrk1b gene is important for endoderm formationQ24646790
Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: Regulation of HSP90-binding activity of FKBP52Q24647502
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligasesQ27644446
Structure of a signal transduction regulator, RACK1, from Arabidopsis thalianaQ27651721
Direct Link between RACK1 Function and Localization at the Ribosome In VivoQ27653299
An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligaseQ27662837
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2Q27732195
Crystal structure of a G-protein beta gamma dimer at 2.1A resolutionQ27732270
Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinasesQ28118261
The WD repeat: a common architecture for diverse functionsQ28143827
Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1Q28215795
WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseasesQ28216786
The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implicationsQ28255027
The MNB/DYRK1A protein kinase: genetic and biochemical propertiesQ28255038
HAN11 binds mDia1 and controls GLI1 transcriptional activityQ28255678
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisQ28292299
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymeraseQ28302692
DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeepingQ28512443
CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperoneQ28581892
Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIIIQ28583955
Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.Q30490193
Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKsQ33217276
Distantly related cousins of MAP kinase: biochemical properties and possible physiological functionsQ33796123
The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytesQ34483597
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.Q34504363
Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survivalQ34548054
The WD-40 repeatQ36379533
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndromeQ36841753
Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cellsQ37339695
Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cellsQ37347577
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)1728-1739
P577publication date2011-07-13
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleDYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation
P478volume1813

Reverse relations

cites work (P2860)
Q64099259A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis
Q89723136An isothermal shift assay for proteome scale drug-target identification
Q39177661Analysis of adult cerebral cortex and hippocampus transcriptomes reveals unique molecular changes in the Ts1Cje mouse model of down syndrome
Q60049142DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B
Q42033560DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome
Q64229393DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169
Q26745413DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome
Q28541616Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors
Q38037304Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control
Q55260854Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A.
Q36130066MiR-1246: a new link of the p53 family with cancer and Down syndrome
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Q89621131TNFα-Signaling Modulates the Kinase Activity of Human Effector Treg and Regulates IL-17A Expression
Q46388847The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling
Q33952905The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation
Q35578920The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase
Q28118783The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2
Q53089292The landscape of somatic mutations in Down syndrome-related myeloid disorders
Q42550882The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation
Q64091236The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair
Q36202520Wdr68 Mediates Dorsal and Ventral Patterning Events for Craniofacial Development
Q27319944Wdr68 requires nuclear access for craniofacial development

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