DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B

scientific article published in PLoS ONE

DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0207779
P932PMC publication ID6264848
P698PubMed publication ID30496304

P50authorRobert M. NissenQ55163376
David SalvenQ93366645
P2093author name stringYang Yu
Jingyi Xu
Estibaliz Alvarado
Mina Yousefelahiyeh
P2860cites workA zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expressionQ21284144
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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1Q24301361
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functionsQ24302518
The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animalsQ24311764
Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinasesQ24316021
The protein interaction landscape of the human CMGC kinase groupQ24338785
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Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly.Q51815976
The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal developmentQ51961245
Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity.Q51987577
Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biologyQ52174827
The Influence of trisomy 21 on facial form and variability.Q53724857
Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsinsQ70250641
Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasomeQ72632766
DYRK1A interacts with histone acetyl transferase p300 and CBP and localizes to enhancersQ91101430
The zebrafish dyrk1b gene is important for endoderm formationQ24646790
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Case report of novel DYRK1A mutations in 2 individuals with syndromic intellectual disability and a review of the literatureQ26765984
Wdr68 requires nuclear access for craniofacial developmentQ27319944
The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2Q28118783
Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndromeQ28144031
A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical regionQ28293718
Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1AQ28362375
Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiationQ28585528
An organelle-specific protein landscape identifies novel diseases and molecular mechanismsQ29147481
WD40 proteins propel cellular networks.Q30156873
A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndromeQ30416401
Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in miceQ30531707
Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions.Q30696543
Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKsQ33217276
The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiationQ33952905
Architecture of the human interactome defines protein communities and disease networksQ34556869
DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assemblyQ34807677
A kinase shRNA screen links LATS2 and the pRB tumor suppressorQ34807689
Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.Q35721878
Wdr68 Mediates Dorsal and Ventral Patterning Events for Craniofacial DevelopmentQ36202520
Novel variants in GNAI3 associated with auriculocondylar syndrome strengthen a common dominant negative effectQ36338193
Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephalyQ36718950
Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitroQ36946204
Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infectionQ37066498
The Drosophila wings apart gene anchors a novel, evolutionarily conserved pathway of neuromuscular developmentQ37269839
Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of CapicuaQ37281524
Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark earsQ37369042
Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal musclesQ37369821
New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down SyndromeQ37500309
E3 Ligase SCFβTrCP-induced DYRK1A Protein Degradation Is Essential for Cell Cycle Progression in HEK293 CellsQ37507511
A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13.Q37530244
Activation, regulation, and inhibition of DYRK1A.Q37815234
DYRK1A: a potential drug target for multiple Down syndrome neuropathologiesQ38154969
Prenatal treatment of Down syndrome: a reality?Q38191420
Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase ComplexQ38749225
DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesisQ38866748
Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.Q38916532
Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A.Q38938802
Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndromeQ38973876
Dissection of the C-Terminal Region of E1A Redefines the Roles of CtBP and Other Cellular Targets in Oncogenic TransformationQ39124298
DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domainQ41124666
Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recyclingQ41337499
Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factorsQ41859522
Inhibition of DYRK1A disrupts neural lineage specification in human pluripotent stem cellsQ41918473
Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase InhibitorsQ41935042
DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndromeQ42033560
Functional Similarity between E6 Proteins of Cutaneous Human Papillomaviruses and the Adenovirus E1A Tumor-Restraining ModuleQ42214281
The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulationQ42550882
Cytoplasmic activation of human nuclear genes in stable heterocaryonsQ42799501
Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPβ and KAISO.Q42835465
Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formationQ43268600
DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocationQ43655626
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.Q43736456
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complexQ43947832
Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation.Q44482754
minibrain: a new protein kinase family involved in postembryonic neurogenesis in DrosophilaQ47070222
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e0207779
P577publication date2018-01-01
P1433published inPLOS OneQ564954
P1476titleDCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B
P478volume13

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