A longevity protein, Lag2, interacts with SCF complex and regulates SCF function

scientific article

A longevity protein, Lag2, interacts with SCF complex and regulates SCF function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOJ.2009.268
P932PMC publication ID2776101
P698PubMed publication ID19763088
P5875ResearchGate publication ID26820668

P2093author name stringTakumi Kamura
Yuan Liu
Tsutomu Kishi
Satoru Mimura
P2860cites workCullin-RING ubiquitin ligases: global regulation and activation cyclesQ21203558
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activityQ22009487
U box proteins as a new family of ubiquitin-protein ligasesQ24291397
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiaeQ24306410
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligasesQ24313433
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligasesQ24337709
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complexQ24337718
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2Q24597101
Protein quality control: U-box-containing E3 ubiquitin ligases join the foldQ44061660
Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex.Q46556619
The COP9 Signalosome Promotes Degradation of Cyclin E during Early Drosophila OogenesisQ46973380
Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans.Q47069590
Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity.Q51088435
Mutants defective in secretory/vacuolar pathways in the EUROFAN collection of yeast disruptants.Q52545437
Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligasesQ77652490
Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34Q24602536
The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimerQ24685712
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligasesQ27644446
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitinationQ27645983
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylationQ27649565
The ubiquitin systemQ27860803
Skp1-Cullin-F-box-dependent degradation of Aah1p requires its interaction with the F-box protein Saf1pQ27929977
LAG2, a gene that determines yeast longevityQ27930003
Ubiquitin-dependent protein degradationQ27931143
A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progressionQ27931729
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complexQ27933259
F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complexQ27934075
Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p.Q27934564
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-boxQ27936367
Cloning and characterization of LAG1, a longevity-assurance gene in yeastQ27937921
A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1pQ27939049
Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.Q27940059
RING finger proteins: mediators of ubiquitin ligase activityQ28139717
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosomeQ28187304
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligaseQ28506124
Cocaine addiction: clues from Drosophila on drugsQ33757100
The abundance of cell cycle regulatory protein Cdc4p is controlled by interactions between its F box and Skp1pQ33957380
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phaseQ34365993
Overproduction of polypeptides corresponding to the amino terminus of the F-box proteins Cdc4p and Met30p inhibits ubiquitin ligase activities of their SCF complexesQ34473396
The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblastsQ35116922
Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanismQ35596995
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugationQ37101488
Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization.Q37385841
Stability of homologue of Slimb F-box protein is regulated by availability of its substrateQ38346254
Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanismsQ39895340
F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18pQ41646870
Translation of aberrant mRNAs lacking a termination codon or with a shortened 3'-UTR is repressed after initiation in yeastQ42240443
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectCullin CDC53 YDL132WQ27548163
Lag2p YOL025WQ27550495
SCF ubiquitin ligase complex subunit SAF1 YBR280CQ27552172
P577publication date2009-11-04
P1433published inThe EMBO JournalQ1278554
P1476titleA longevity protein, Lag2, interacts with SCF complex and regulates SCF function

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cites work (P2860)
Q27664416A Dual E3 Mechanism for Rub1 Ligation to Cdc53
Q50336194CSN- and CAND1-dependent remodelling of the budding yeast SCF complex.
Q52729296Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression.
Q88697987Hermes Transposon Mutagenesis Shows [URE3] Prion Pathology Prevented by a Ubiquitin-Targeting Protein: Evidence for Carbon/Nitrogen Assimilation Cross Talk and a Second Function for Ure2p in Saccharomyces cerevisiae
Q40322425Neddylation and CAND1 independently stimulate SCF ubiquitin ligase activity in Candida albicans
Q34714927New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1.
Q27935518Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function
Q38585206Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast
Q35866120Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis
Q33987001Structural and functional insights to ubiquitin-like protein conjugation.
Q35266319The TFIIH subunit Tfb3 regulates cullin neddylation

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