| scholarly article | Q13442814 |
| P2093 | author name string | Raymond J Deshaies | |
| Anjanabha Saha | |||
| P2860 | cites work | Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases | Q34230579 |
| Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. | Q34617875 | ||
| A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination | Q35687263 | ||
| NEDD8 recruits E2-ubiquitin to SCF E3 ligase. | Q39731260 | ||
| Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast | Q40430046 | ||
| The human ubiquitin-conjugating enzyme Cdc34 controls cellular proliferation through regulation of p27Kip1 protein levels. | Q40470648 | ||
| Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing | Q42816031 | ||
| New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications | Q44001816 | ||
| Protein interactions within the N-end rule ubiquitin ligation pathway | Q44276071 | ||
| Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex | Q44333860 | ||
| Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization | Q45345753 | ||
| Bi-substrate kinetic analysis of an E3-ligase-dependent ubiquitylation reaction | Q46213452 | ||
| Sequential E2s drive polyubiquitin chain assembly on APC targets | Q46225392 | ||
| Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. | Q46711534 | ||
| Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase | Q47315840 | ||
| Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity. | Q51088435 | ||
| Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology | Q58215681 | ||
| Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins | Q80262122 | ||
| A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination | Q82857335 | ||
| Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex | Q24294734 | ||
| Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase | Q24306203 | ||
| The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae | Q24306410 | ||
| Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases | Q24313433 | ||
| Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase | Q24337721 | ||
| Recognition of the polyubiquitin proteolytic signal | Q24530006 | ||
| The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1 | Q24551152 | ||
| Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha | Q24554289 | ||
| The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2 | Q24597101 | ||
| Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase | Q27640370 | ||
| Mechanisms underlying ubiquitination | Q27860656 | ||
| F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex | Q27934075 | ||
| A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p | Q27939049 | ||
| Function and regulation of cullin-RING ubiquitin ligases | Q28131707 | ||
| The Nedd8-conjugated ROC1-CUL1 Core Ubiquitin Ligase Utilizes Nedd8 Charged Surface Residues for Efficient Polyubiquitin Chain Assembly Catalyzed by Cdc34 | Q28201996 | ||
| Back to the future with ubiquitin | Q28240711 | ||
| The SCF ubiquitin ligase: insights into a molecular machine | Q28279993 | ||
| Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging | Q28307753 | ||
| The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice | Q28592951 | ||
| Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation | Q28609667 | ||
| A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein | Q29547884 | ||
| Ubiquitin-binding domains | Q29614358 | ||
| A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin | Q29618006 | ||
| Phosphorylation of Sic1p by G 1 Cdk Required for Its Degradation and Entry into S Phase | Q29618007 | ||
| Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1). | Q33898769 | ||
| Nedd8 on cullin: building an expressway to protein destruction. | Q33976667 | ||
| P433 | issue | 1 | |
| P304 | page(s) | 21-31 | |
| P577 | publication date | 2008-10-01 | |
| P1433 | published in | Molecular Cell | Q3319468 |
| P1476 | title | Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation | |
| P478 | volume | 32 |
| Q27657571 | 60th residues of ubiquitin and Nedd8 are located out of E2-binding surfaces, but are important for K48 ubiquitin-linkage |
| Q33819289 | A CULLINary ride across the secretory pathway: more than just secretion |
| Q39308261 | A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924 |
| Q27670841 | A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases |
| Q28834146 | A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes |
| Q28301510 | A comparative analysis of the ubiquitination kinetics of multiple degrons to identify an ideal targeting sequence for a proteasome reporter |
| Q27934969 | A longevity protein, Lag2, interacts with SCF complex and regulates SCF function |
| Q37622653 | A snapshot of ubiquitin chain elongation: lysine 48-tetra-ubiquitin slows down ubiquitination |
| Q92534284 | A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade |
| Q33875519 | Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency |
| Q37285218 | Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation |
| Q37459809 | Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase |
| Q41829071 | All change: protein conformation and the ubiquitination reaction cascade |
| Q47744222 | All-trans retinoic acid induces autophagic degradation of ubiquitin-like modifier activating enzyme 3 in acute promyelocytic leukemia cells |
| Q27646351 | Allosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp78 |
| Q36115907 | An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition. |
| Q29616732 | An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer |
| Q24307382 | Autoregulation of Parkin activity through its ubiquitin-like domain |
| Q34619941 | Auxin perception--structural insights |
| Q27671574 | BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer |
| Q27027816 | Building and remodelling Cullin-RING E3 ubiquitin ligases |
| Q29619578 | Building ubiquitin chains: E2 enzymes at work |
| Q34202918 | C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues |
| Q50296648 | CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus |
| Q50296644 | CAND1 binds cytosolic CRL E3 ubiquitin ligases |
| Q40136931 | CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire |
| Q43239447 | CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. |
| Q37867729 | COP9 signalosome function in the DDR |
| Q42511084 | COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation |
| Q38015388 | CRL Ubiquitin Ligases and DNA Damage Response |
| Q41060304 | CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation |
| Q35017567 | CSN-mediated deneddylation differentially modulates Ci155 proteolysis to promote Hedgehog signalling responses |
| Q36780798 | CSN6 positively regulates c-Jun in a MEKK1-dependent manner |
| Q38736268 | CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis |
| Q37609233 | CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases |
| Q54215914 | CUL5 is required for thalidomide-dependent inhibition of cellular proliferation |
| Q52877633 | Can hyperthermic intraperitoneal chemotherapy efficiency be improved by blocking the DNA repair factor COP9 signalosome? |
| Q36850952 | Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins |
| Q52729296 | Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression. |
| Q84982757 | Characterization of the Cullin7 E3 ubiquitin ligase — Heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity |
| Q35612223 | Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity |
| Q53316010 | Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis. |
| Q47380507 | Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases |
| Q34671745 | Composition, roles, and regulation of cullin-based ubiquitin e3 ligases. |
| Q57269909 | Conformational flexibility and rotation of the RING domain in activation of cullin–RING ligases |
| Q44109926 | Constitutively active Cullin‐RING‐Ligases fail to rescue loss of NEDD8 conjugation in Schizosaccharomyces pombe |
| Q37827465 | Control of Cullin-Ring Ubiquitin Ligase Activity by Nedd8 |
| Q24647543 | Control of cell growth by the SCF and APC/C ubiquitin ligases |
| Q100311434 | Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics |
| Q34035751 | Crossover localisation is regulated by the neddylation posttranslational regulatory pathway |
| Q27678871 | Crystal structure and versatile functional roles of the COP9 signalosome subunit 1 |
| Q48529643 | Cubism and the cell cycle: the many faces of the APC/C |
| Q31095156 | Cul4B regulates neural progenitor cell growth |
| Q47284253 | Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation. |
| Q27932725 | Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. |
| Q38059746 | Cullin-RING Ligases as Attractive Anti-cancer Targets |
| Q26746956 | Cullin-RING ligases in regulation of autophagy |
| Q27692621 | Cycle inhibiting factors (cifs): cyclomodulins that usurp the ubiquitin-dependent degradation pathway of host cells. |
| Q24629359 | Cysteine-based regulation of the CUL3 adaptor protein Keap1 |
| Q39196067 | DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase |
| Q48343629 | DENEDDYLASE1 Protein Counters Automodification of Neddylating Enzymes to Maintain NEDD8 Protein Homeostasis in Arabidopsis |
| Q36216079 | Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism |
| Q42956366 | Detection of sequential polyubiquitylation on a millisecond timescale |
| Q24311975 | Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER |
| Q28086765 | Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B |
| Q38533869 | Diversity of COP9 signalosome structures and functional consequences |
| Q48023330 | Drug discovery: Fresh target for cancer therapy |
| Q89087654 | Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension |
| Q24319983 | Dynamic regulation of the COP9 signalosome in response to DNA damage |
| Q38124517 | Dynamic regulation of ubiquitin-dependent cell cycle control |
| Q34433677 | Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics |
| Q27680817 | E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin |
| Q28301074 | E2s: structurally economical and functionally replete |
| Q35770195 | Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control. |
| Q37267368 | Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex |
| Q36226432 | Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2 |
| Q92105561 | Enzymatic Logic of Ubiquitin Chain Assembly |
| Q42928058 | Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex. |
| Q28740322 | Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate |
| Q42007391 | F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage |
| Q24314570 | FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51 |
| Q47229846 | Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors |
| Q38103251 | Flipping the switch from g1 to s phase with e3 ubiquitin ligases |
| Q36392344 | Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8. |
| Q39462405 | Global identification of modular cullin-RING ligase substrates |
| Q34540701 | Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family |
| Q28831238 | Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1 |
| Q47782407 | Increasing the Unneddylated Cullin1 Portion Rescues the csn Phenotypes by Stabilizing Adaptor Modules To Drive SCF Assembly |
| Q35042995 | Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression |
| Q39094288 | Inhibition of NEDD8 and FAT10 ligase activities through the degrading enzyme NEDD8 ultimate buster 1: A potential anticancer approach |
| Q28484619 | Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G |
| Q36770693 | Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function |
| Q90060978 | In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast |
| Q37213763 | JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinases |
| Q41817100 | Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons. |
| Q38920601 | Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants. |
| Q35036898 | Knockdown of SCF(Skp2) function causes double-parked accumulation in the nucleus and DNA re-replication in Drosophila plasmatocytes |
| Q37415096 | Lessons from fungal F-box proteins |
| Q38026589 | MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy |
| Q34782977 | Macromolecular juggling by ubiquitylation enzymes |
| Q37983242 | Many jobs for one good cop – The COP9 signalosome guards development and defense |
| Q34387857 | Mechanism of Cullin3 E3 Ubiquitin Ligase Dimerization |
| Q42406812 | Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme |
| Q37623965 | Mechanisms of ubiquitin transfer by the anaphase-promoting complex. |
| Q33594018 | Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide |
| Q27678830 | Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases |
| Q30653286 | Molecular architecture and mechanism of the anaphase-promoting complex |
| Q40337840 | Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34. |
| Q50894927 | Molecular dynamics investigation on the poor sensitivity of A171T mutant NEDD8-activating enzyme (NAE) for MLN4924. |
| Q35311062 | Mono-ubiquitination Drives Nuclear Export of the Human DCN1-like Protein hDCNL1 |
| Q37349016 | Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails |
| Q39531701 | Mutational analysis of VACM-1/cul5 exons in cancer cell lines |
| Q38855262 | NEDD8 Inhibition Overcomes CKS1B-Induced Drug Resistance by Upregulation of p21 in Multiple Myeloma |
| Q37840759 | NEDD8 Pathways in Cancer, Sine Quibus Non |
| Q35947206 | NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway |
| Q89686909 | NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly |
| Q38776083 | Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury |
| Q40322425 | Neddylation and CAND1 Independently Stimulate SCF Ubiquitin Ligase Activity in Candida albicans |
| Q34288710 | Neddylation dysfunction in Alzheimer's disease |
| Q37284979 | Neddylation is required for herpes simplex virus type I (HSV-1)-induced early phase interferon-beta production |
| Q36535453 | Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling |
| Q39193303 | Neddylation pathway regulates the proliferation and survival of macrophages |
| Q37186465 | Neddylation plays an important role in the regulation of murine and human dendritic cell function |
| Q38992669 | Overactivated neddylation pathway as a therapeutic target in lung cancer. |
| Q41668145 | Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation |
| Q38681448 | Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. |
| Q33716987 | Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways |
| Q34793372 | Phage Display to Identify Nedd8‐Mimicking Peptides as Inhibitors of the Nedd8 Transfer Cascade |
| Q28273339 | Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization |
| Q33717656 | Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect |
| Q24304915 | Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate |
| Q35601400 | Proteasome functional insufficiency in cardiac pathogenesis |
| Q26865081 | Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes |
| Q48538797 | Protein neddylation and its alterations in human cancers for targeted therapy |
| Q34042816 | Protein neddylation: beyond cullin-RING ligases |
| Q38585206 | Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast |
| Q35653286 | Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor |
| Q24322903 | Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates |
| Q34032707 | Rbx1 flexible linker facilitates cullin-RING ligase function before neddylation and after deneddylation |
| Q33857419 | Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates |
| Q34949214 | Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases |
| Q37995680 | Regulation of NF‐κB by ubiquitination and degradation of the IκBs |
| Q26827548 | Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic |
| Q57289570 | Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway |
| Q39643768 | Resveratrol enhances anti-proliferative effect of VACM-1/cul5 in T47D cancer cells |
| Q92201008 | Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways |
| Q42700446 | SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex |
| Q38285971 | SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. |
| Q28588762 | SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression |
| Q38102567 | SCFs in the new millennium |
| Q42009353 | SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function |
| Q50497193 | SMALL ACIDIC PROTEIN1 acts with RUB modification components, the COP9 signalosome, and AXR1 to regulate growth and development of Arabidopsis |
| Q24611517 | Scaffold proteins: hubs for controlling the flow of cellular information |
| Q27678117 | Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase |
| Q48352437 | Self-regulating ubiquitin ligases. |
| Q38728113 | Specificity and disease in the ubiquitin system |
| Q38016673 | Spotlight on the role of COP1 in tumorigenesis |
| Q36744696 | Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation |
| Q48594712 | Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission. |
| Q27675990 | Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases |
| Q36988986 | Structural Basis for a Reciprocal Regulation between SCF and CSN |
| Q27675332 | Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes |
| Q28542494 | Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer |
| Q27681760 | Structural and enzymatic characterization of a host-specificity determinant fromSalmonella |
| Q33987001 | Structural and functional insights to ubiquitin-like protein conjugation. |
| Q36932100 | Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle |
| Q24621898 | Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl |
| Q24300948 | Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase |
| Q35151712 | Structural regulation of cullin-RING ubiquitin ligase complexes |
| Q87893432 | Structure function relations in PDZ-domain-containing proteins: Implications for protein networks in cellular signalling |
| Q27670574 | Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface |
| Q24299638 | Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8 |
| Q37811107 | Structure, function and mechanism of the anaphase promoting complex (APC/C) |
| Q27657740 | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases |
| Q37289330 | Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex |
| Q36082492 | Suppression of glioblastoma by targeting the overactivated protein neddylation pathway |
| Q36802367 | Suramin inhibits cullin-RING E3 ubiquitin ligases. |
| Q90970664 | TRAF6 neddylation drives inflammatory arthritis by increasing NF-κB activation |
| Q24337489 | TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes |
| Q34043797 | Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation |
| Q34563129 | Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy |
| Q36215406 | Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells |
| Q33908666 | Targeting the neddylation pathway to suppress the growth of prostate cancer cells: therapeutic implication for the men's cancer |
| Q49887000 | The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity |
| Q27931851 | The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae. |
| Q41877791 | The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis |
| Q50800615 | The COP9 signalosome: its regulation of cullin-based E3 ubiquitin ligases and role in photomorphogenesis |
| Q36660304 | The Colossus of Ubiquitylation: Decrypting a Cellular Code |
| Q34769739 | The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1. |
| Q37849305 | The Cullin-RING Ubiquitin-Protein Ligases |
| Q36873556 | The Cyclomodulin Cycle Inhibiting Factor (CIF) Alters Cullin Neddylation Dynamics |
| Q42602280 | The E3 Ubiquitin Ligase SCF(Cyclin F) Transmits AKT Signaling to the Cell-Cycle Machinery |
| Q33927244 | The Essential Functions of NEDD8 Are Mediated via Distinct Surface Regions, and Not by Polyneddylation in Schizosaccharomyces pombe |
| Q24311644 | The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73 |
| Q33659621 | The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases |
| Q34202686 | The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy |
| Q37269140 | The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia |
| Q57809721 | The Nedd8-activating enzyme inhibitor MLN4924 (TAK-924/Pevonedistat) induces apoptosis via c-Myc-Noxa axis in head and neck squamous cell carcinoma |
| Q37289267 | The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression |
| Q41002609 | The San1 Ubiquitin Ligase Functions Preferentially with Ubiquitin-conjugating Enzyme Ubc1 during Protein Quality Control |
| Q35266319 | The TFIIH subunit Tfb3 regulates cullin neddylation |
| Q37479215 | The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCFCdc4. |
| Q45345755 | The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis |
| Q37873586 | The cullin protein family |
| Q37163747 | The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. |
| Q34770671 | The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome. |
| Q33885264 | The human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF-dependent ubiquitination |
| Q36079517 | The molecular basis of ubiquitin-like protein NEDD8 deamidation by the bacterial effector protein Cif. |
| Q37866988 | The role of ubiquitylation in nerve cell development |
| Q34994359 | The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation |
| Q26746044 | The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions |
| Q34960760 | The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2. |
| Q36268060 | The ubiquitin-proteasome system of Saccharomyces cerevisiae |
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