Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

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Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1 is …
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scholarly articleQ13442814

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P356DOI10.7554/ELIFE.17101
P3181OpenCitations bibliographic resource ID2580979
P932PMC publication ID5012860
P698PubMed publication ID27595565

P50authorCheryl ArrowsmithQ5092682
Krzysztof KrajewskiQ56876100
Paul A DaRosaQ56876101
Scott B RothbartQ62070938
Evan M CornettQ84783414
Brian D StrahlQ41544665
Peter J. BrownQ42713845
Michael B. MajorQ55136937
Joseph S. HarrisonQ55458142
P2093author name stringFeng Yan
Dorothy A Erie
Brian Kuhlman
Dennis Goldfarb
Bradley M Dickson
Rachel E Klevit
Angela H Guo
Daniel V Cantu
Lilia Kaustov
Zimeng M Li
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Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1Q27651995
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E2s: structurally economical and functionally repleteQ28301074
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Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1α at chromatinQ34297995
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The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sitesQ34344734
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Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylationQ36381487
A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choiceQ36506865
Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.Q36542574
UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffoldQ36566344
A reversible protection strategy to improve Fmoc-SPPS of peptide thioesters by the N-Acylurea approach.Q36571620
UbSRD: The Ubiquitin Structural Relational DatabaseQ36665172
Reading between the Lines: "ADD"-ing Histone and DNA Methylation Marks toward a New Epigenetic "Sum".Q36703430
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognitionQ36768848
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USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated DegradationQ36944526
Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylationQ36948989
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugationQ37101488
Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.Q37348708
High throughput characterization of combinatorial histone codesQ37379616
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DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitinationQ38865045
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replicationQ39098794
UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway.Q39254333
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.Q41791632
Light-induced nuclear export reveals rapid dynamics of epigenetic modificationsQ41888822
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UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9.Q42824871
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Expression and purification of soluble His(6)-tagged TEV proteaseQ46261487
P4510describes a project that usesImageQuantQ112270642
P407language of work or nameEnglishQ1860
P921main subjectDNA methylationQ874745
ubiquitinationQ33059483
P577publication date2016-09-06
P1433published ineLifeQ2000008
P1476titleHemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1
P478volume5