Multivalent engagement of chromatin modifications by linked binding modules

scientific article (publication date: December 2007)

Multivalent engagement of chromatin modifications by linked binding modules is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1013443204
P356DOI10.1038/NRM2298
P8608Fatcat IDrelease_xstok3cp3rhx5hyy6n36gyj45q
P3181OpenCitations bibliographic resource ID2415593
P932PMC publication ID4690530
P698PubMed publication ID18037899
P5875ResearchGate publication ID5809636

P50authorCharles David AllisQ1064064
Alexander J RuthenburgQ57740603
Haitao LiQ30502674
P2093author name stringDinshaw J Patel
P2860cites workIdentification and analysis of functional elements in 1% of the human genome by the ENCODE pilot projectQ21061203
Structure and ligand of a histone acetyltransferase bromodomainQ22009928
Combined Action of PHD and Chromo Domains Directs the Rpd3S HDAC to Transcribed ChromatinQ58422628
Chromatin Fiber Folding: Requirement for the Histone H4 N-terminal TailQ61041700
Multivalency in Ligand DesignQ62009674
Nonrandom utilization of acetylation sites in histones isolated from Tetrahymena. Evidence for functionally distinct H4 acetylation sitesQ70275855
Modulation of chromatin folding by histone acetylationQ71941995
Electron capture dissociation for structural characterization of multiply charged protein cationsQ73493699
A trivalent system from vancomycin.D-ala-D-Ala with higher affinity than avidin.biotinQ74490796
Extraction, purification and analysis of histonesQ80422717
Chromatin compaction by a polycomb group protein complexQ81067457
Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and InhibitorsQ88519588
Histone proteomics and the epigenetic regulation of nucleosome mobilityQ36913037
H3K27 demethylases, at long lastQ36965110
Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14Q37270587
Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomesQ37524499
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3.Q37592817
Site-specific binding affinities within the H2B tail domain indicate specific effects of lysine acetylationQ38299037
Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc lectin. Dependence on fine structural features.Q38354946
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatinQ40362512
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryoteQ40903819
Developmental roles for chromatin and chromosomal structureQ40954487
Histone acetylation: chromatin in actionQ41468916
The site-specific installation of methyl-lysine analogs into recombinant histonesQ41978659
Altered nucleosomes of active nucleolar chromatin contain accessible histone H3 in its hyperacetylated formsQ42218269
Selective recognition of acetylated histones by bromodomains in transcriptional co-activatorsQ42288180
Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylationQ43604842
Mapping global histone acetylation patterns to gene expressionQ44928696
Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1.Q44957855
A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin.Q46009407
Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactionsQ47070476
Creating designer histones by native chemical ligationQ51053417
Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction.Q52570974
Regions of variant histone His2AvD required for Drosophila development.Q52571223
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase.Q52572600
Gene regulation: a finger on the mark.Q53379835
RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.Q53547949
Translating the Histone CodeQ22065840
The role of heterochromatin in centromere functionQ22065919
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signalsQ22122053
Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?Q22251049
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4Q24294553
Isolation of human NURF: a regulator of Engrailed gene expressionQ24299509
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOFQ24305335
Repression of p53 activity by Smyd2-mediated methylationQ24315991
An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenesQ24316326
Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferaseQ24320001
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repressionQ24338124
Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fractionQ24563194
Genome-wide maps of chromatin state in pluripotent and lineage-committed cellsQ24632506
On the attribution and additivity of binding energiesQ24634899
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNAQ24645346
A genomic code for nucleosome positioningQ24650238
The utility of ETD mass spectrometry in proteomic analysisQ24682151
Structure and function of a human TAFII250 double bromodomain moduleQ27622657
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomainsQ27641772
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activationQ27643078
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repressionQ27647088
Autoregulation of the Rsc4 Tandem Bromodomain by Gcn5 AcetylationQ27647842
Refinement of Eco RI endonuclease crystal structure: a revised protein chain tracingQ27685433
High-resolution profiling of histone methylations in the human genomeQ27860906
The language of covalent histone modificationsQ27860931
A bivalent chromatin structure marks key developmental genes in embryonic stem cellsQ27860977
The role of chromatin during transcriptionQ27860995
Chromatin modifications and their functionQ27861067
Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.Q27929914
Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylasesQ27931861
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcriptionQ27932406
Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongationQ27935250
Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylationQ27935667
Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiaeQ27936975
Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundariesQ27937031
Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex.Q27939462
The complex language of chromatin regulation during transcriptionQ28131748
Heterochromatin protein 1 binds to nucleosomes and DNA in vitroQ28140141
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulationQ28141828
Histone acetylation and an epigenetic codeQ28143767
Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteinsQ28187121
Coordinated histone modifications mediated by a CtBP co-repressor complexQ28191656
CoREST is an integral component of the CoREST- human histone deacetylase complexQ28199886
Signaling network model of chromatinQ28202952
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinaseQ28205257
Cellular memory and the histone codeQ28213805
The nucleosome: from genomic organization to genomic regulationQ28240753
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodellingQ28242453
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURFQ28242466
A histone H3 lysine 27 demethylase regulates animal posterior developmentQ28248320
Regulation of LSD1 histone demethylase activity by its associated factorsQ28270391
Modifications of human histone H3 variants during mitosisQ28273983
Defining an epigenetic codeQ28281451
Genome regulation by polycomb and trithorax proteinsQ28289984
Genomic DNA methylation: the mark and its mediatorsQ28290773
Nuclear organization of the genome and the potential for gene regulationQ28303751
MLL targets SET domain methyltransferase activity to Hox gene promotersQ28609771
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
Perceptions of epigeneticsQ29547310
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickersQ29547350
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcriptionQ29547846
Genomic maps and comparative analysis of histone modifications in human and mouseQ29614418
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic markQ29614516
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2Q29614519
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2AQ29614520
Histone H4-K16 acetylation controls chromatin structure and protein interactionsQ29614521
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylationQ29614524
Methylation of histone H3 Lys 4 in coding regions of active genesQ29614680
Transcriptional activation by recruitmentQ29615048
Epigenetics: a landscape takes shapeQ29616623
Synthesis of proteins by native chemical ligationQ29616750
Reading protein modifications with interaction domainsQ29622877
Long-distance combinatorial linkage between methylation and acetylation on histone H3 N terminiQ30444527
Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase IIIQ33775383
Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repressionQ33886463
Histone modifications: combinatorial complexity or cumulative simplicity?Q33936701
Crosstalk between CARM1 methylation and CBP acetylation on histone H3.Q33963308
Regulated nucleosome mobility and the histone code.Q34364723
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.Q34531694
PTMs on H3 variants before chromatin assembly potentiate their final epigenetic stateQ34575324
Auxiliary-mediated site-specific peptide ubiquitylation.Q34609386
On the use of the word 'epigenetic'.Q34615615
Theoretical analysis of epigenetic cell memory by nucleosome modification.Q34629739
Chromatin remodeling and cancer, Part I: Covalent histone modificationsQ34682092
Histone modification patterns associated with the human X chromosomeQ34683351
Multisite protein modification and intramolecular signalingQ36060432
The role of chromatin structure in regulating the expression of clustered genes.Q36256687
The histone code at DNA breaks: a guide to repair?Q36259096
Assembly of variant histones into chromatinQ36280301
Dynamic nucleosomes and gene transcriptionQ36456418
The nucleosome: a little variation goes a long way.Q36579363
Characterization of histones and their post-translational modifications by mass spectrometryQ36678174
Structure and acetyl-lysine recognition of the bromodomainQ36908432
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)983-994
P577publication date2007-12-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleMultivalent engagement of chromatin modifications by linked binding modules
P478volume8

Reverse relations

cites work (P2860)
Q28548172A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaT
Q27676403A Poised Chromatin Platform for TGF-β Access to Master Regulators
Q38756663A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks
Q64996582A Versatile Lentiviral Delivery Toolkit for Proximity-dependent Biotinylation in Diverse Cell Types.
Q39923243A bromodomain-DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT.
Q33922397A case study in cross-talk: the histone lysine methyltransferases G9a and GLP.
Q28485041A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation
Q41936960A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding
Q36003708A conserved function for the H2A.Z C terminus.
Q47580853A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.
Q33836710A differential proteome screening system for post-translational modification-dependent transcription factor interactions.
Q33961160A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
Q47119223A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding.
Q40097842A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation
Q36560070A multi-parametric flow cytometric assay to analyze DNA-protein interactions.
Q30557163A novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation.
Q36418916A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.
Q28587686A novel mammalian flavin-dependent histone demethylase
Q27679986A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases
Q28480471A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin
Q28482317A simple histone code opens many paths to epigenetics
Q57294610A thermodynamic model for multivalency in 14-3-3 protein-protein interactions
Q27692030ATP dependent chromatin remodeling enzymes in embryonic stem cells
Q34531263ATX1-generated H3K4me3 is required for efficient elongation of transcription, not initiation, at ATX1-regulated genes
Q35174982Absence of MSY2 in mouse oocytes perturbs oocyte growth and maturation, RNA stability, and the transcriptome
Q43573529Accessibility of the histone H3 tail in the nucleosome for binding of paired readers.
Q28076086Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer
Q47422824Acetylation and methylation of sperm histone 3 lysine 27 (H3K27ac and H3K27me3) are associated with bull fertility.
Q36385770Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes
Q96304255Acetylation/methylation at lysine 9 in histone H3 as a mark of nucleosome asymmetry in human somatic breast cells
Q50611631Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD.
Q35709124Advances in epigenetics and epigenomics for neurodegenerative diseases
Q34540779Ampelopsin induces apoptosis by regulating multiple c-Myc/S-phase kinase-associated protein 2/F-box and WD repeat-containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma cells
Q33743418An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors
Q27655247An Alpha Motif at Tas3 C Terminus Mediates RITS cis Spreading and Promotes Heterochromatic Gene Silencing
Q39502343An acetylation switch regulates SUMO-dependent protein interaction networks.
Q33522047An evolutionary consequence of dosage compensation on Drosophila melanogaster female X-chromatin structure?
Q38160822An evolving understanding of nuclear receptor coregulator proteins.
Q41015328An iridium(iii)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent
Q33843625Analysis of histones and chromatin in Xenopus laevis egg and oocyte extracts
Q30437407Analysis of histones in Xenopus laevis. I. A distinct index of enriched variants and modifications exists in each cell type and is remodeled during developmental transitions
Q30437404Analysis of histones in Xenopus laevis. II. mass spectrometry reveals an index of cell type-specific modifications on H3 and H4.
Q42172387Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state.
Q30435010Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression
Q34178082Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information
Q34731914Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments
Q37962018Arginine/lysine-methyl/methyl switches: biochemical role of histone arginine methylation in transcriptional regulation
Q36401114Asymmetrically modified nucleosomes
Q34998802Atypical E2fs control lymphangiogenesis through transcriptional regulation of Ccbe1 and Flt4.
Q35186308BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing
Q37692934Bacterial SET domain proteins and their role in eukaryotic chromatin modification
Q49497915Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis
Q34359019Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code
Q26862414Beyond the ENCODE project: using genomics and epigenomics strategies to study enhancer evolution
Q21142665Biochemical profiling of histone binding selectivity of the yeast bromodomain family
Q47295917Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer
Q34997981Bookmarking the genome: maintenance of epigenetic information.
Q34620395Brain function and chromatin plasticity
Q35680194Brain region-specific expression of Fxyd1, an Mecp2 target gene, is regulated by epigenetic mechanisms.
Q24315005Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release
Q21563338CHD3 proteins and polycomb group proteins antagonistically determine cell identity in Arabidopsis
Q28660713CR Cistrome: a ChIP-Seq database for chromatin regulators and histone modification linkages in human and mouse
Q37247874CXXC finger protein 1 contains redundant functional domains that support embryonic stem cell cytosine methylation, histone methylation, and differentiation
Q33590983CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin
Q35690516Calibrating ChIP-Seq with Nucleosomal Internal Standards to Measure Histone Modification Density Genome Wide
Q49685857Caught with One's Zinc Fingers in the Genome Integrity Cookie Jar.
Q35546910Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8+ T cells
Q42591933Cellular and viral chromatin proteins are positive factors in the regulation of adenovirus gene expression
Q27664073Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1
Q38645627Chemical Biology for Investigating Epigenetic Functions of Lysine Acetyltransferases (KATs).
Q89175973Chemical and Biochemical Perspectives of Protein Lysine Methylation
Q36108201Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response
Q89984096ChromID identifies the protein interactome at chromatin marks
Q38596337Chromatin Structure of Epstein-Barr Virus Latent Episomes
Q39451519Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns.
Q37733528Chromatin as an expansive canvas for chemical biology
Q28483211Chromatin computation
Q36853222Chromatin dynamics at the replication fork: there's more to life than histones
Q38192410Chromatin dynamics: interplay between remodeling enzymes and histone modifications
Q64062869Chromatin fiber structural motifs as regulatory hubs of genome function?
Q39653622Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark
Q34107271Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice
Q37087397Chromatin proteomics and epigenetic regulatory circuits.
Q37321372Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways.
Q42413539Chromatin regulation Tip(60)s the balance in embryonic stem cell self-renewal
Q28083608Chromatin regulation at the frontier of synthetic biology
Q51035830Chromatin regulators: weaving epigenetic nets
Q37141498Chromatin structure and the inheritance of epigenetic information
Q26999888Chromatin targeting drugs in cancer and immunity
Q38042377Chromatin-linked determinants of zygotic genome activation
Q37925912Chromatin-mediated Candida albicans virulence.
Q34055162Chromatin-mediated epigenetic regulation in the malaria parasite Plasmodium falciparum
Q37151715Chromatin-modifying agents for epigenetic reprogramming and endogenous neural stem cell-mediated repair in stroke
Q37684600Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer
Q37634047Combinatorial H3K9acS10ph histone modification in IgH locus S regions targets 14-3-3 adaptors and AID to specify antibody class-switch DNA recombination
Q30414675Combinatorial epigenetic patterns as quantitative predictors of chromatin biology
Q35852758Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells
Q37860060Combinatorial readout of dual histone modifications by paired chromatin-associated modules
Q27681246Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription
Q26824645Combining genomic and proteomic approaches for epigenetics research
Q58739474Comprehensive analysis of lysine crotonylation in proteome of maintenance hemodialysis patients
Q38258085Computational and experimental methods to decipher the epigenetic code
Q37969685Conserved RB functions in development and tumor suppression
Q28082738Conserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1
Q42365675Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia
Q28508692Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways
Q27657619Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
Q35877421Coupling between Histone Conformations and DNA Geometry in Nucleosomes on a Microsecond Timescale: Atomistic Insights into Nucleosome Functions
Q38010167Crosstalk among Epigenetic Pathways Regulates Neurogenesis
Q39350728Cryo-electron microscopy of chromatin biology.
Q27678211Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins
Q60199986DNA damage: a histone-code mediator leaves the stage
Q58699717Deciphering and engineering chromodomain-methyllysine peptide recognition
Q37931616Deciphering arginine methylation: Tudor tells the tale.
Q37069551Deciphering histone 2A deubiquitination
Q37358580Decoding the epigenetic language of neuronal plasticity
Q35056454Decoding the trans-histone crosstalk: methods to analyze H2B ubiquitination, H3 methylation and their regulatory factors.
Q89879844Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins
Q30431944Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60-dependent transcriptional regulation and apoptotic pathway
Q38182186Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes.
Q37138660Developmental exposure to endocrine disrupting chemicals alters the epigenome: Identification of reprogrammed targets
Q37288260Developmental reprogramming of cancer susceptibility
Q37264119Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading
Q33801481Dissecting the binding mechanism of the linker histone in live cells: an integrated FRAP analysis.
Q57478076Distinct Pathways Affected by Menin versus MLL1/MLL2 in MLL-rearranged Acute Myeloid Leukemia
Q39529456Diurnal changes in the histone H3 signature H3K9ac|H3K27ac|H3S28p are associated with diurnal gene expression in Arabidopsis
Q49377046Double duty: ZMYND8 in the DNA damage response and cancer
Q57128184Drawing on disorder: How viruses use histone mimicry to their advantage
Q41866613Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression
Q34794271Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin
Q34093054Druggability of methyl-lysine binding sites
Q34625280Dual coordination of post translational modifications in human protein networks
Q34859890Dynamic access of the glucocorticoid receptor to response elements in chromatin.
Q39690333Dynamic and Combinatorial Landscape of Histone Modifications during the Intraerythrocytic Developmental Cycle of the Malaria Parasite.
Q33738330Dynamic changes in genome-wide histone H3 lysine 4 methylation patterns in response to dehydration stress in Arabidopsis thaliana
Q39321147Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells
Q37128008Dynamic histone variant exchange accompanies gene induction in T cells
Q37829706Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language".
Q34857637Dynamic protein methylation in chromatin biology
Q58602722Dynamic recognition and linkage specificity in K63 di-ubiquitin and TAB2 NZF domain complex
Q39440034Dynamics of Srf, p300 and histone modifications during cardiac maturation in mouse
Q39141712EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures.
Q30494900Efficient cell migration requires global chromatin condensation
Q39222596Elucidating combinatorial histone modifications and crosstalks by coupling histone-modifying enzyme with biotin ligase activity
Q38552464Elucidating the mechanisms of transcription regulation during heart development by next-generation sequencing
Q50045989Emerging Roles for Epigenetic Programming in the Control of Inflammatory Signaling Integration in Heath and Disease.
Q33676492Engram formation in psychiatric disorders
Q96230995Enhancer RNAs are an important regulatory layer of the epigenome
Q34025898Enhancer function: new insights into the regulation of tissue-specific gene expression
Q37587846Environmental influences on epigenetic profiles.
Q35910362Epigenetic Control of Circadian Clock Operation during Development
Q56501909Epigenetic Mechanisms of Mental Retardation
Q55260556Epigenetic Modifications Associated to Neuroinflammation and Neuropathic Pain After Neural Trauma.
Q26772307Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models
Q37371624Epigenetic control of T-helper-cell differentiation
Q34460981Epigenetic control of aging
Q28574550Epigenetic control of female puberty
Q34431964Epigenetic drugs against cancer: an evolving landscape
Q21129487Epigenetic effects of stress and corticosteroids in the brain
Q37575071Epigenetic histone code and autoimmunity
Q28749982Epigenetic mechanisms in mammals
Q27021810Epigenetic mechanisms in mood disorders: targeting neuroplasticity
Q36465823Epigenetic mechanisms in stroke and epilepsy
Q50086224Epigenetic modifications of gene expression by lifestyle and environment
Q24657549Epigenetic principles and mechanisms underlying nervous system functions in health and disease
Q29616621Epigenetic protein families: a new frontier for drug discovery
Q37520580Epigenetic regulation in African trypanosomes: a new kid on the block
Q37976256Epigenetic regulation in RCC: opportunities for therapeutic intervention?
Q36876345Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication
Q40010061Epigenetic regulation of cardiac muscle-specific genes in H9c2 cells by Interleukin-18 and histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide
Q38244664Epigenetic regulation of female puberty.
Q39427516Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration
Q26998380Epigenetic regulation of persistent pain
Q37190667Epigenetic regulation of the electrophysiological phenotype of human embryonic stem cell-derived ventricular cardiomyocytes: insights for driven maturation and hypertrophic growth.
Q37697504Epigenetic regulatory mechanisms in vertebrate eye development and disease.
Q36642513Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts
Q51733858Epigenetic therapies - a new direction in clinical medicine.
Q28077082Epigenetics in Cancer: A Hematological Perspective
Q28071369Epigenetics in Intestinal Epithelial Cell Renewal
Q38210945Epigenetics in cardiac development, function, and disease.
Q37637387Epigenetics in cardiovascular disease
Q34633331Epigenetics in kidney development and renal disease
Q92072853Epigenetics of Bladder Cancer: Where Biomarkers and Therapeutic Targets Meet
Q37992592Epigenetics: Concepts and relevance to IBD pathogenesis
Q42030420Epigenetics: Tools and Technologies
Q53123771Epigenetics: a potential key mechanism involved in the pathogenesis of cardiorenal syndromes.
Q55011560Epigenomic Modifications Mediating Antibody Maturation.
Q42378495Evidence for the association of chromatin and microRNA regulation in the human genome
Q26827293Evidence for the involvement of epigenetics in the progression of renal fibrogenesis
Q36381664Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ.
Q33760663Expanding the landscape of chromatin modification (CM)-related functional domains and genes in human
Q61489847Exploiting CRISPR-Cas9 technology to investigate individual histone modifications
Q33534633Expression in aneuploid Drosophila S2 cells
Q43132772Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II.
Q53415760Formation of Chromatin Subcompartments by Phase Separation.
Q37267202From UVs to metastases: modeling melanoma initiation and progression in the mouse.
Q58106929Functional Genomics of Drought Tolerance in Bioenergy Crops
Q28654627Functional analysis of limb transcriptional enhancers in the mouse
Q51027882Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes.
Q38615077Functional coupling between writers, erasers and readers of histone and DNA methylation
Q42573893GATA2 regulates GATA1 expression through LSD1-mediated histone modification
Q37068678GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression
Q37194170Gene-specific transcriptional activation mediated by the p150 subunit of the chromatin assembly factor 1.
Q41850218Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones.
Q37468826Genome reprogramming during sporulation.
Q33479753Genome-wide analysis of interactions between ATP-dependent chromatin remodeling and histone modifications
Q47438320Global Proteome Analysis Links Lysine Acetylation to Diverse Functions in Oryza Sativa
Q28541596Global quantitative modeling of chromatin factor interactions
Q38853113Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.
Q33786471H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb
Q33466779H3 k36 methylation helps determine the timing of cdc45 association with replication origins
Q36657584H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation
Q28477443H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development
Q24319807H3R42me2a is a histone modification with positive transcriptional effects
Q91555780HATs off for the Lasker awardees
Q41454518HDAC3 Inhibitor RGFP966 Modulates Neuronal Memory for Vocal Communication Signals in a Songbird Model
Q35620862Handpicking epigenetic marks with PHD fingers.
Q41918292Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features.
Q24307750Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor Cells
Q28831238Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1
Q42369727Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes.
Q33854961High resolution electron transfer dissociation studies of unfractionated intact histones from murine embryonic stem cells using on-line capillary LC separation: determination of abundant histone isoforms and post-translational modifications
Q27006839Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Q35372285Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway.
Q35983522Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα.
Q33963926Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination.
Q35592200Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation
Q37454264Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena
Q39584708Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.
Q33875106Histone H3 trimethylated at lysine 4 is enriched at probable transcription start sites in Trypanosoma brucei
Q35195947Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin
Q35889368Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription
Q33844929Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly
Q42774953Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation
Q35063526Histone H4 acetylation differentially modulates arginine methylation by an in Cis mechanism
Q38796064Histone Modifications and Cancer
Q57978730Histone Recognition by Tandem Modules and Modulation by Multiple PTMs
Q37398618Histone acetylation: truth of consequences?
Q37970955Histone acetyltransferases and deacetylases: molecular and clinical implications to gastrointestinal carcinogenesis
Q37918348Histone deacetylases in neural stem cells and induced pluripotent stem cells
Q89886134Histone deacetylases in vascular permeability and remodeling associated with acute lung injury
Q24299384Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors
Q35787101Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation
Q37995722Histone marks: repairing DNA breaks within the context of chromatin
Q36812958Histone methyl transferases and demethylases; can they link metabolism and transcription?
Q34861446Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression
Q92505940Histone methylation and the DNA damage response
Q28591780Histone methyltransferase SETD3 regulates muscle differentiation
Q42316676Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions
Q34297533Histone phosphorylation: a chromatin modification involved in diverse nuclear events
Q24310431Histone recognition and large-scale structural analysis of the human bromodomain family
Q37139778Histone tails: ideal motifs for probing epigenetics through chemical biology approaches
Q33630867Histone variants: emerging players in cancer biology
Q35229609Histones: at the crossroads of peptide and protein chemistry
Q36650425Homodimeric PHD Domain-containing Rco1 Subunit Constitutes a Critical Interaction Hub within the Rpd3S Histone Deacetylase Complex
Q37514183How eukaryotic genes are transcribed
Q36916855Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.
Q52362092Hypothalamic Epigenetics Driving Female Puberty.
Q35091749ISWI remodelling of physiological chromatin fibres acetylated at lysine 16 of histone H4.
Q35880093Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation
Q38175981Identification and interrogation of combinatorial histone modifications.
Q42534687Identification and verification of lysine propionylation and butyrylation in yeast core histones using PTMap software
Q24635918Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
Q33514240Identification of a functional network of human epigenetic silencing factors
Q92758663Identification of dual histone modification-binding protein interaction by combining mass spectrometry and isothermal titration calorimetric analysis
Q37214667Identification of methyllysine peptides binding to chromobox protein homolog 6 chromodomain in the human proteome
Q38946242Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF.
Q52631343Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.
Q42398073Identifying the combinatorial effects of histone modifications by association rule mining in yeast
Q35237004Immediate chromatin immunoprecipitation and on-bead quantitative PCR analysis: a versatile and rapid ChIP procedure
Q39037754Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models
Q21245051In vitro nuclear interactome of the HIV-1 Tat protein
Q50780217Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia
Q36688921Induction of human fetal hemoglobin expression by adenosine-2',3'-dialdehyde.
Q38198633Integrated mechanisms of CaMKII-dependent ventricular remodeling
Q42182620Interaction of SET domains with histones and nucleic acid structures in active chromatin.
Q27934482Interaction of transcriptional regulators with specific nucleosomes across the Saccharomyces genome
Q38196193Interpreting the language of histone and DNA modifications
Q36029333Investigating cell surface galectin-mediated cross-linking on glycoengineered cells
Q92708333KAP1 is an antiparallel dimer with a functional asymmetry
Q27317357KDM2B is implicated in bovine lethal multi-organic developmental dysplasia
Q34336457Keeping it in the family: diverse histone recognition by conserved structural folds
Q41614015Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Q35124384L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure
Q60926316LAIPT: Lysine Acetylation Site Identification with Polynomial Tree
Q50594693Learning chromatin states with factorized information criteria
Q34275371Leukaemogenesis: more than mutant genes
Q37324755Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin
Q38477081Locus-specific biochemical epigenetics/chromatin biochemistry by insertional chromatin immunoprecipitation
Q34412648Looping back to leap forward: transcription enters a new era
Q38825939Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Q37062105Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics
Q24644959Lysine acetylation: codified crosstalk with other posttranslational modifications
Q41701650Lysine demethylase KDM2A inhibits TET2 to promote DNA methylation and silencing of tumor suppressor genes in breast cancer
Q34258578Lysine succinylation and lysine malonylation in histones.
Q34178072Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability
Q38853829MECP2, a multi-talented modulator of chromatin architecture
Q34066027Malleable machines take shape in eukaryotic transcriptional regulation
Q37398637Marks to stop the clock: histone modifications and checkpoint regulation in the DNA damage response
Q27001576Mass spectrometry-based detection and assignment of protein posttranslational modifications
Q24613876Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b
Q53606806Mechanisms of Evolutionary Innovation Point to Genetic Control Logic as the Key Difference Between Prokaryotes and Eukaryotes.
Q30411151Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis
Q34551588Mitotic bookmarking of genes: a novel dimension to epigenetic control.
Q38169800Modifiable risk factors in periodontal disease: epigenetic regulation of gene expression in the inflammatory response
Q27652763Molecular Basis of the Interaction of Saccharomyces cerevisiae Eaf3 Chromo Domain with Methylated H3K36
Q27666875Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1-CoREST Complex
Q38161393Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis
Q27660605Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1
Q24338569Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1
Q24316968Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt
Q38927506Multicavity macrocyclic hosts.
Q37454345Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association
Q33987248Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis
Q37742105Multiple sclerosis etiology: beyond genes and environment
Q36018598Multivalency governs HP1α association dynamics with the silent chromatin state.
Q37525441Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin
Q36948989Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation
Q37379697NMR assignments and histone specificity of the ING2 PHD finger
Q34699724Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylases
Q26799278New insights into the epigenetic control of satellite cells
Q39581390Novel cinnamyl hydroxyamides and 2-aminoanilides as histone deacetylase inhibitors: apoptotic induction and cytodifferentiation activity
Q37148474Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.
Q88667939Nuclear organization mediates cancer-compromised genetic and epigenetic control
Q39825886Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor
Q35175545Nucleosome contact triggers conformational changes of Rpd3S driving high-affinity H3K36me nucleosome engagement
Q86246092Nucleosome structure and function
Q24304841Nucleosome-interacting proteins regulated by DNA and histone methylation
Q89468143Observing protein interaction dynamics to chemically defined chromatin fibers by colocalization single-molecule fluorescence microscopy
Q91644556On the relations of phase separation and Hi-C maps to epigenetics
Q38067764One, two, three: how histone methylation is read
Q37832806Operating on chromatin, a colorful language where context matters
Q36744726Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C).
Q35209782Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines
Q33533679Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients
Q89479726PBRM1 bromodomains variably influence nucleosome interactions and cellular function
Q37326237PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus
Q37235746PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks
Q33819263PHD fingers: epigenetic effectors and potential drug targets
Q24594648PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53
Q37618064PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65
Q24338563PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
Q24300856PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B
Q35813603Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy
Q26995208Partners in crime: The role of tandem modules in gene transcription
Q37827422Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes
Q34387013Peptide microarrays to interrogate the "histone code".
Q36821309Perceiving the epigenetic landscape through histone readers.
Q34185471Perspectives on the discovery of small-molecule modulators for epigenetic processes
Q27006437Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
Q35932499Phase transitions in the assembly of multivalent signalling proteins
Q30303131Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development
Q35128231Phosphorylation of histone H2B serine 32 is linked to cell transformation.
Q38323586Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events
Q38216962Phosphorylation-dependent regulation of plant chromatin and chromatin-associated proteins.
Q93053251Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation
Q42559301Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression
Q34548233Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin
Q42804095Pneumocystis carinii expresses an active Rtt109 histone acetyltransferase
Q33450714Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence
Q36854975Polyubiquitylation of histone H2B.
Q26852536Post-translational modifications of histones that influence nucleosome dynamics
Q36172945Potent and selective bivalent inhibitors of BET bromodomains.
Q27012961Predicting later-life outcomes of early-life exposures
Q30985843Prediction of Plant Height in Arabidopsis thaliana Using DNA Methylation Data
Q50665698Prevalence of paunch calf syndrome carriers in Italian Romagnola cattle
Q24319024Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression
Q37872394Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity
Q42369525Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes.
Q24311427Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program
Q24603107Proteomic investigation of epigenetics in neuropsychiatric disorders: a missing link between genetics and behavior?
Q52349061Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1.
Q40628134Quantitative assessment of protein interaction with methyl-lysine analogues by hybrid computational and experimental approaches
Q33854968Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36
Q30375585Quantitative proteomic analysis of histone modifications
Q35876546Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown
Q35728265RNA polymerase II carboxyl-terminal domain phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36
Q90747992RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation
Q28589254RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis
Q34829400RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis
Q30435879RVB1/RVB2: running rings around molecular biology
Q87873470Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress
Q37421645Reader domain specificity and lysine demethylase-4 family function
Q35092783Readers of histone modifications
Q36703430Reading between the Lines: "ADD"-ing Histone and DNA Methylation Marks toward a New Epigenetic "Sum".
Q50494189Reading chromatin signatures after DNA double-strand breaks.
Q37775455Reading chromatin: insights from yeast into YEATS domain structure and function.
Q38103962Readout of epigenetic modifications
Q30490570Real-time imaging of histone H4 hyperacetylation in living cells
Q26781752Recent findings and technological advances in phosphoproteomics for cells and tissues
Q34252584Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3.
Q24303887Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
Q27670916Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
Q24299712Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein
Q24337001Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF)
Q36754984Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131
Q103806779Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation
Q37777343Regulation of DNA replication by chromatin structures: accessibility and recruitment.
Q89181535Regulation of chromatin and gene expression by metabolic enzymes and metabolites
Q37022129Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression
Q27681142Retinoblastoma-binding Protein 1 Has an Interdigitated Double Tudor Domain with DNA Binding Activity
Q37399562Role of chromatin states in transcriptional memory
Q39957980Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation
Q34308191Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination
Q24338590SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors
Q57285505SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
Q30274768SUMO and Chromatin Remodeling
Q37598005Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2.
Q35620891Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing
Q38748150Selective targeting of epigenetic reader domains
Q26765666Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation
Q38514865Shaping of interphase chromosomes by the microtubule network.
Q37421692Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies
Q36926242Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells
Q36835792Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells
Q42796150Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions.
Q37234667Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4.
Q34628002Small-molecular modulators of cancer-associated epigenetic mechanisms
Q37961728Small-molecule chromatin-modifying agents: therapeutic applications
Q34990803Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.
Q40454155SnapShot: Histone readers.
Q38552741Sound of silence: the properties and functions of repressive Lys methyltransferases.
Q37829703Spreading chromatin into chemical biology
Q27940068Spt10 and Spt21 are required for transcriptional silencing in Saccharomyces cerevisiae
Q92003087Strategies for Generating Modified Nucleosomes: Applications within Structural Biology Studies
Q27658848Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain
Q27676760Structural Insight into Recognition of Methylated Histone Tails by Retinoblastoma-binding Protein 1
Q41036649Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain
Q38205661Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks
Q38620787Structural insight into CBP bromodomain-mediated recognition of acetylated histone H3K56ac
Q24634118Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
Q34667860Structural plasticity in human heterochromatin protein 1β
Q27685367Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation
Q27665789Suppression of inflammation by a synthetic histone mimic
Q48818625Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness
Q38887327Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates
Q27937803Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex
Q47252056Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease
Q24630530TGF-β control of stem cell differentiation genes
Q24317243TRIM24 links a non-canonical histone signature to breast cancer
Q36633583TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice
Q37829997Targeted large-scale analysis of protein acetylation
Q38099273Targeting deregulated epigenetic control in cancer
Q36398751Targeting epigenetic regulations in cancer
Q38191266Targeting epigenetic regulators for cancer therapy
Q38094663Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities
Q38231327Targeting the histone orthography of cancer: drugs for writers, erasers and readers
Q33606391The "histone mimicry" by pathogens
Q47269443The 10-nm chromatin fiber and its relationship to interphase chromosome organization
Q24297599The CH2 domain of CBP/p300 is a novel zinc finger
Q27667577The CW domain, a new histone recognition module in chromatin proteins
Q37580481The Chd1 chromatin remodeler shifts hexasomes unidirectionally.
Q41181386The Co-Expression Pattern of p63 and HDAC1: A Potential Way to Disclose Stem Cells in Interfollicular Epidermis
Q36188457The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation.
Q61442990The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail
Q21093224The HTLV-1 Tax interactome
Q60958597The Impact of Protein Acetylation/Deacetylation on Systemic Lupus Erythematosus
Q35780124The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset
Q36581565The MTA family proteins as novel histone H3 binding proteins
Q26747254The Metabolic Impact on Histone Acetylation and Transcription in Ageing
Q64092150The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise
Q34180042The PHD finger: a versatile epigenome reader
Q35793285The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain.
Q37732532The Role of Snail in EMT and Tumorigenesis
Q60925241The Role of Tripartite Motif Family Proteins in TGF-β Signaling Pathway and Cancer
Q24306590The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
Q34692752The biology of lysine acetylation integrates transcriptional programming and metabolism
Q34468312The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3
Q28512635The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs
Q37819663The cell biology of disease: FSHD: copy number variations on the theme of muscular dystrophy
Q36282953The dynamics of HMG protein-chromatin interactions in living cells
Q37452573The emerging role of HP1 in the DNA damage response
Q41905839The emerging role of epigenetic mechanisms in the etiology of neural tube defects
Q24624411The epigenetic landscape of addiction
Q51091490The epigenetic landscape of clear-cell renal cell carcinoma
Q28068278The epigenome: the next substrate for engineering
Q34864525The expanding epigenetic landscape of non-model organisms
Q60959023The histone deacetylase NlHDAC1 regulates both female and male fertility in the brown planthopper, Nilaparvata lugens
Q28594155The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
Q30428295The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly.
Q37375531The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription.
Q24628821The many roles of histone deacetylases in development and physiology: implications for disease and therapy
Q38896147The mechanisms of HSC activation and epigenetic regulation of HSCs phenotypes
Q35060864The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.
Q38877902The molecular hallmarks of epigenetic control
Q38848092The nucleosome: orchestrating DNA damage signaling and repair within chromatin.
Q28542970The proteomic and genomic teratogenicity elicited by valproic acid is preventable with resveratrol and α-tocopherol
Q27005703The role of O-GlcNAc transferase in regulating the gene transcription of developing and failing hearts
Q37784574The role of Sp1 and Sp3 in normal and cancer cell biology
Q34300706The role of WDR5 in silencing human fetal globin gene expression
Q41887428The role of bromodomain proteins in regulating gene expression
Q34459181The role of chromatin structure in cell migration
Q37777676The significance, development and progress of high-throughput combinatorial histone code analysis
Q27654188The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation
Q43093740The specification and maintenance of renal cell types by epigenetic factors
Q51281223The tumor suppressor inhibitor of growth 4 binds double-stranded DNA through its disordered central region
Q27666447Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease
Q30413802Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA.
Q84441692Tools and landscapes of epigenetics
Q35861914Towards a mechanism for histone chaperones
Q35146397Towards understanding methyllysine readout.
Q37969686Transcriptional activators and activation mechanisms
Q88035347Transcriptional and Epigenetic Control of Mammalian Olfactory Epithelium Development
Q37863271Transcriptional and epigenetic networks in haematological malignancy
Q35064355Transcriptional and epigenetic networks of helper T and innate lymphoid cells.
Q33732988Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes
Q41901525Transcriptional enhancers in development and disease
Q57443233Transcriptomics and proteomics
Q38137526Tudor: a versatile family of histone methylation 'readers'.
Q35836441Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans
Q54617530Two distinct roles of ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1) at promoters and within transcribed regions of ATX1-regulated genes.
Q37885195UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance.
Q34038791Unbiased proteomic screen for binding proteins to modified lysines on histone H3.
Q52370170Uncovering the mechanistic basis for specific recognition of monomethylated H3K4 by the CW domain of Arabidopsis histone methyltransferase SDG8.
Q26998460Unlocking epigenetic codes in neurogenesis
Q36055604Vascular smooth muscle progenitor cells: building and repairing blood vessels.
Q35208296Vitamin d and susceptibility of chronic lung diseases: role of epigenetics
Q92099533Why are so many MLL lysine methyltransferases required for normal mammalian development?
Q28535037Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549
Q51126964Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression
Q34476349Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small molecules
Q34950050YEATS domain proteins: a diverse family with many links to chromatin modification and transcription.
Q24338606ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression
Q38244758Zebrafish as a model to study the role of DNA methylation in environmental toxicology.
Q38846065Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.
Q33604849c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis
Q34014168dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing
Q36341573dKDM5/LID regulates H3K4me3 dynamics at the transcription-start site (TSS) of actively transcribed developmental genes.
Q27337637p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes

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