Epigenetic mechanisms in stroke and epilepsy

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Epigenetic mechanisms in stroke and epilepsy is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1042829188
P356DOI10.1038/NPP.2012.134
P932PMC publication ID3521969
P698PubMed publication ID22892394
P5875ResearchGate publication ID230670832

P2093author name stringR Suzanne Zukin
Jee-Yeon Hwang
Kelly A Aromolaran
P2860cites workCoREST: a functional corepressor required for regulation of neural-specific gene expressionQ22003747
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
Translating the Histone CodeQ22065840
Transcriptional and epigenetic mechanisms of addictionQ22251017
Advances in autism genetics: on the threshold of a new neurobiologyQ22251023
The co-repressor mSin3A is a functional component of the REST-CoREST repressor complexQ22253387
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2Q22337290
Identification of new epilepsy treatments: issues in preclinical methodologyQ24289140
Histone deacetylases (HDACs): characterization of the classical HDAC familyQ24535587
HDAC2 negatively regulates memory formation and synaptic plasticity.Q24611806
An epigenetic blockade of cognitive functions in the neurodegenerating brainQ24611928
Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxinQ24629286
microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampusQ24631418
Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genesQ24644926
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradationQ24653723
MicroRNAs as biomarkers for myocardial infarctionQ27000432
Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA MethylationQ27677188
Chromatin modifications and their functionQ27861067
The complex language of chromatin regulation during transcriptionQ28131748
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genesQ28189644
Corepressor-dependent silencing of chromosomal regions encoding neuronal genesQ28210691
Regulation of neuronal traits by a novel transcriptional complexQ28214009
Role for reelin in the development of granule cell dispersion in temporal lobe epilepsyQ28214937
Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampusQ28236724
De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancerQ35927834
Epigenetic mechanisms in memory formation.Q36011654
Calcium-permeable AMPA channels in neurodegenerative disease and ischemiaQ36477673
Combinatorial chromatin modifications and memory storage: a code for memory?Q36495048
Noncoding RNAs in the mammalian central nervous system.Q36507566
Histone deacetylase inhibitors: gathering paceQ36509550
Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal deathQ36726811
Histone deacetylases: focus on the nervous systemQ36832256
The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity.Q36854587
Emerging role of epigenetics in stroke: part 1: DNA methylation and chromatin modificationsQ36938455
MicroRNA-directed transcriptional gene silencing in mammalian cellsQ36945167
Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental strokeQ37167043
Sex differences in caspase activation after strokeQ37172671
Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in ratsQ37283453
Remodeling of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit composition in hippocampal neurons after global ischemiaQ37294821
Ube3a is required for experience-dependent maturation of the neocortex.Q37340937
Decoding the epigenetic language of neuronal plasticityQ37358580
Histone deacetylases: salesmen and customers in the post-translational modification market.Q37389553
Regulation of non-coding RNA networks in the nervous system--what's the REST of the story?Q37399818
Fine-tuning neural gene expression with microRNAsQ37524788
Expression of histone deacetylases in cellular compartments of the mouse brain and the effects of ischemiaQ35237734
miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132Q35475193
Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticusQ35530042
Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neuronsQ35676840
Neurological disease: listening to gene silencers.Q35679362
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain functionQ35779169
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cellsQ28239651
Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)Q28243974
Regulation of apoptosis by alternative pre-mRNA splicingQ28259246
A molecular chaperone inducer protects neurons from ER stressQ28259344
Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal deathQ28260806
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylationQ28265681
Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genesQ28267234
MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesteraseQ28267386
2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structureQ28268494
Regulation of LSD1 histone demethylase activity by its associated factorsQ28270391
Control of chromosome stability by the beta-TrCP-REST-Mad2 axisQ28273354
Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009Q28274778
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBPQ28295041
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturationQ28296169
Adult epilepsyQ28304952
The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's diseaseQ28305485
Chromatin crosstalk in development and disease: lessons from RESTQ28306534
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cellsQ28366303
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132Q28510360
Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genesQ28511419
Ischemic insults derepress the gene silencer REST in neurons destined to dieQ28567540
Distribution of lysine-specific demethylase 1 in the brain of rat and its response in transient global cerebral ischemiaQ28574354
Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genesQ28576708
Neuronal expression of zinc finger transcription factor REST/NRSF/XBR geneQ28579417
Acetylation: a regulatory modification to rival phosphorylation?Q29614886
DNA methylation and human diseaseQ29615417
Multivalent engagement of chromatin modifications by linked binding modulesQ29617236
Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesisQ30490207
Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsyQ30504521
BDNF and epilepsy: too much of a good thing?Q31865271
Expression profile of MicroRNAs in young stroke patientsQ33514818
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cellsQ33652889
Epileptogenesis in the immature brain: emerging mechanismsQ33656567
Emerging insights into the genesis of epilepsyQ33678164
Epilepsy in autism is associated with intellectual disability and gender: evidence from a meta-analysisQ45375790
A national profile of childhood epilepsy and seizure disorderQ46064697
The p.Val66Met polymorphism in the BDNF gene protects against early seizures in Rett syndromeQ46628392
The chloride transporter Na(+)-K(+)-Cl- cotransporter isoform-1 contributes to intracellular chloride increases after in vitro ischemia.Q46923567
Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements.Q48029551
HSPBAP1 is found extensively in the anterior temporal neocortex of patients with intractable epilepsyQ48136588
Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampusQ48202574
Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brainQ48431778
The prevalence of autistic spectrum disorder in children surveyed in a tertiary care epilepsy clinicQ48518400
Histone modifications in kainate-induced status epilepticusQ48608876
Neuroprotective effects of valproic acid following transient global ischemia in ratsQ48687041
Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neuronsQ48701586
Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damageQ48723297
Increased expression of histone deacetylases 2 in temporal lobe epilepsy: a study of epileptic patients and rat modelsQ48851824
Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984.Q51052283
DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS.Q51927994
REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.Q52049234
MeCP2 and drug addictionQ52297172
DNA methyltransferase contributes to delayed ischemic brain injury.Q52972663
Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil.Q53291090
Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus.Q54396512
Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtypeQ57985772
Diamondoids and oil are not foreverQ59099009
Suppressed epileptogenesis in BDNF mutant miceQ60695087
Histone acetyl transferases as emerging drug targets.Q37540911
Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapiesQ37615626
Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesisQ37699484
NaV1.1 channels and epilepsyQ37701079
Spatially restricting gene expression by local translation at synapsesQ37715121
Epilepsy in Rett syndrome---the experience of a National Rett CenterQ37759048
Autism and epilepsy: historical perspectiveQ37761458
Sex differences in cerebral ischemia: possible molecular mechanismsQ37779053
Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies.Q37787304
Epigenetic modifications as therapeutic targetsQ37800011
Every methyl counts--epigenetic calculusQ37812416
The role of inflammation in epilepsyQ37816957
MicroRNAs and epigeneticsQ37852129
The role of DNA methylation in mammalian developmentQ37865930
Epigenetic regulation of gene expression in physiological and pathological brain processesQ37870034
Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticityQ37872394
microRNAs in neurons: manifold regulatory roles at the synapseQ37874365
Analytical aspects of microRNA in diagnostics: a review.Q37894396
The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis?Q37898154
K-acetylation and its enzymes: overview and new developmentsQ37924189
Clinical spectrum of SCN2A mutations.Q37949707
Dynamic regulation of DNA methylation during mammalian developmentQ37961978
Non-coding RNAs with essential roles in neurodegenerative disordersQ37977656
Differential DNA methylation patterns define status epilepticus and epileptic tolerance.Q38498575
Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neuronsQ38531931
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.Q39333674
Possible involvement of DNA methylation in NKCC1 gene expression during postnatal development and in response to ischemiaQ39705766
The human neurokinin B gene, TAC3, and its promoter are regulated by Neuron Restrictive Silencing Factor (NRSF) transcription factor family.Q39836088
Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsyQ39893640
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.Q39901302
Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.Q39985716
miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivoQ40159726
Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtinQ40269204
Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damageQ40676818
Eradicating the mediators of neuronal death with a fine-tooth combQ41467226
Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence levelQ41563633
Mice overexpressing rat heat shock protein 70 are protected against cerebral infarctionQ41741332
Histone deacetylase inhibitors preserve white matter structure and function during ischemia by conserving ATP and reducing excitotoxicityQ41763185
Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbilQ42441854
Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicityQ42452526
Valproate induces DNA demethylation in nuclear extracts from adult mouse brainQ42934618
Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures.Q43757475
Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus.Q44156166
Expression of Ca(2+)-permeable AMPA receptor channels primes cell death in transient forebrain ischemiaQ44963469
Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathwayQ44964543
A microRNA-based gene dysregulation pathway in Huntington's diseaseQ45307225
REST maintains self-renewal and pluripotency of embryonic stem cellsQ33694355
Dynamic changes in the human methylome during differentiationQ33736539
Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause diseaseQ33942130
Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures.Q33979161
Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain.Q34073214
The human histone deacetylase familyQ34119283
Tuning acetylation levels with HAT activators: Therapeutic strategy in neurodegenerative diseasesQ34137377
MicroRNA in ischemic stroke etiology and pathologyQ34137995
Temporal lobe epilepsy induces differential expression of hippocampal miRNAs including let-7e and miR-23a/bQ34168627
Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures.Q34170732
The science of stroke: mechanisms in search of treatmentsQ34212337
The many faces of REST oversee epigenetic programming of neuronal genesQ34449364
Reciprocal actions of REST and a microRNA promote neuronal identityQ34479303
Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiationQ34519687
Predictors of seizure onset in Rett syndrome.Q34570181
Reelin, lipoprotein receptors and synaptic plasticityQ34575575
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.Q34587312
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.Q34624060
Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition.Q34627485
Epigenetic mechanisms in cognitionQ34630009
Exploring the opioid system by gene knockoutQ34641459
Epilepsy in autism: features and correlatesQ34729922
HCN channels in behavior and neurological disease: too hyper or not active enough?Q34777401
Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsyQ34922351
Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsyQ34962732
microRNAs at the synapseQ35011182
microRNA: emerging therapeutic targets in acute ischemic diseasesQ35011762
Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapyQ35039281
To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathwaysQ35102824
miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemiaQ35105106
Status epilepticus decreases glutamate receptor 2 mRNA and protein expression in hippocampal pyramidal cells before neuronal deathQ35119121
Mechanisms, challenges and opportunities in strokeQ35120144
Coassembly of REST and its cofactors at sites of gene repression in embryonic stem cells.Q35145504
Inherited neuronal ion channelopathies: new windows on complex neurological diseasesQ35226085
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)167-182
P577publication date2012-08-15
P1433published inNeuropsychopharmacologyQ2261280
P1476titleEpigenetic mechanisms in stroke and epilepsy
P478volume38

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