Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes

scientific journal article

Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes is …
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scholarly articleQ13442814

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P819ADS bibcode2004PNAS..10110458B
P356DOI10.1073/PNAS.0401827101
P3181OpenCitations bibliographic resource ID2660249
P932PMC publication ID478591
P698PubMed publication ID15240883
P5875ResearchGate publication ID8468143

P50authorBerthold GottgensQ41050340
Alexander W BruceQ37389356
Ian C WoodQ40364974
P2093author name stringMichael I Sadowski
Ian J Donaldson
Michael Chapman
Noel J Buckley
Sally A Yerbury
P2860cites workCoREST: a functional corepressor required for regulation of neural-specific gene expressionQ22003747
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripesQ22065831
The co-repressor mSin3A is a functional component of the REST-CoREST repressor complexQ22253387
Silencing is golden: negative regulation in the control of neuronal gene transcriptionQ40957956
Neural specific expression of the m4 muscarinic acetylcholine receptor gene is mediated by a RE1/NRSE-type silencing elementQ41191861
Fibronectin signaling stimulates BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repressionQ42516858
Analysis of transcriptional regulatory sequences of the N-methyl-D-aspartate receptor 2A subunit gene in cultured cortical neurons and transgenic miceQ44160918
A computational "genome walk" technique to identify regulatory interactions in gene networks.Q47715339
Distribution of transcription factor binding sites in the yeast genome suggests abundance of coordinately regulated genesQ47883325
Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements.Q48029551
Silencing the type II sodium channel gene: a model for neural-specific gene regulationQ48466004
Expression of the rat m4 muscarinic acetylcholine receptor gene is regulated by the neuron-restrictive silencer element/repressor element 1.Q48795497
Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factorsQ56901246
REST: A mammalian silencer protein that restricts sodium channel gene expression to neuronsQ24312038
The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genesQ24314740
Nucleotides of transcription factor binding sites exert interdependent effects on the binding affinities of transcription factorsQ24514899
Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genomeQ24530466
Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryoQ24530508
Use of chromatin immunoprecipitation to clone novel E2F target promotersQ24548317
The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytesQ24550992
NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and functionQ24634087
Genomic targets of the human c-Myc proteinQ24672480
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genesQ28189644
Corepressor-dependent silencing of chromosomal regions encoding neuronal genesQ28210691
A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cellsQ28211203
Regulation of neuronal traits by a novel transcriptional complexQ28214009
Ischemic insults derepress the gene silencer REST in neurons destined to dieQ28567540
Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genesQ28576708
Neuronal expression of zinc finger transcription factor REST/NRSF/XBR geneQ28579417
Tissue-specific expression of the L1 cell adhesion molecule is modulated by the neural restrictive silencer elementQ30494551
SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation.Q30702540
Regulation of GluR2 promoter activity by neurotrophic factors via a neuron-restrictive silencer elementQ30866082
Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling.Q34194938
The neural restrictive silencer element can act as both a repressor and enhancer of L1 cell adhesion molecule gene expression during postnatal developmentQ35984621
The neuron-restrictive silencer element: a dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brainQ36161198
Identification of potential target genes for the neuron-restrictive silencer factorQ37366344
Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer elementQ38329948
Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanismQ38361779
Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complexQ39584884
Interaction of the repressor element 1-silencing transcription factor (REST) with target genesQ40612109
Distinct RE-1 silencing transcription factor-containing complexes interact with different target genesQ40625759
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectRE1-silencing transcription factorQ21990471
P304page(s)10458-10463
P577publication date2004-07-06
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleGenome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes
P478volume101

Reverse relations

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Q42188512SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
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Q36667246Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types
Q27317144Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival
Q34317893Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels
Q37399843Squelching glioblastoma stem cells by targeting REST for proteasomal degradation
Q28756728Stem cells have different needs for REST
Q41987823Stepwise assembly of functional C-terminal REST/NRSF transcriptional repressor complexes as a drug target.
Q34990529Striatal pre-enkephalin overexpression improves Huntington's disease symptoms in the R6/2 mouse model of Huntington's disease
Q37708096Suppression of Sin3A activity promotes differentiation of pluripotent cells into functional neurons
Q24682593Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites
Q38097255Tailoring the models of transcription
Q36007472Target genes of neuron-restrictive silencer factor are abnormally up-regulated in human myotilinopathy
Q90424102Telomere repeat-binding factor 2 binds extensively to extra-telomeric G-quadruplexes and regulates the epigenetic status of several gene promoters
Q38289162The DNA binding factor Hmg20b is a repressor of erythroid differentiation
Q50568919The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
Q39175572The Importance of REST for Development and Function of Beta Cells
Q36590443The RE1 binding protein REST regulates oligodendrocyte differentiation
Q36506026The REST remodeling complex protects genomic integrity during embryonic neurogenesis.
Q26783252The Transcription Repressor REST in Adult Neurons: Physiology, Pathology, and Diseases(1,2,3)
Q34349554The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding
Q28305485The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease
Q37969749The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathology
Q34647749The critical role of protein arginine methyltransferase prmt8 in zebrafish embryonic and neural development is non-redundant with its paralogue prmt1.
Q36213657The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation
Q39313679The emerging field of epigenetics in neurodegeneration and neuroprotection
Q36167442The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases
Q48715573The hairy and enhancer of split 1 is a negative regulator of the repressor element silencer transcription factor
Q25257408The inflammatory and normal transcriptome of mouse bladder detrusor and mucosa
Q36002307The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells
Q48126673The methylazoxymethanol acetate rat model: molecular and epigenetic effect in the developing prefrontal cortex: An Editorial Highlight for 'Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in t
Q37118557The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease
Q42014461The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes
Q28582790The rest repression of the neurosecretory phenotype is negatively modulated by BHC80, a protein of the BRAF/HDAC complex
Q33604808The transcription factor REST is lost in aggressive breast cancer
Q40012523The transcriptional repressor REST/NRSF modulates hedgehog signaling
Q37533481Towards a genome-wide reconstruction of cis-regulatory networks in the human genome
Q33778522Transcriptional activation of REST by Sp1 in Huntington's disease models
Q42829255Transcriptional activators and repressors for the neuron-specific expression of a metabotropic glutamate receptor
Q39647545Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability
Q28505649Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation
Q42776718Transcriptome analysis revealed impaired cAMP responsiveness in PHF21A-deficient human cells
Q35917441Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST.
Q52658502White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage.
Q39333674Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.
Q36242764Zebrafish rest regulates developmental gene expression but not neurogenesis
Q28574490miR-29a modulates neuronal differentiation through targeting REST in mesenchymal stem cells
Q92634464miR-29c regulates neurogliogenesis in the mammalian retina through REST
Q37390499α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses

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