Silencing the type II sodium channel gene: a model for neural-specific gene regulation

scientific article published on July 1, 1992

Silencing the type II sodium channel gene: a model for neural-specific gene regulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/0896-6273(92)90218-3
P8608Fatcat IDrelease_ovxtscfv3jdi5jpiu72qhxbqpm
P698PubMed publication ID1321645

P2093author name stringG. Mandel
H. J. Tsay
J. A. Chong
S. D. Kraner
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)37-44
P577publication date1992-07-01
P1433published inNeuronQ3338676
P1476titleSilencing the type II sodium channel gene: a model for neural-specific gene regulation
P478volume9

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cites work (P2860)
Q36563187A calcium responsive element that regulates expression of two calcium binding proteins in Purkinje cells
Q34588290A clustering property of highly-degenerate transcription factor binding sites in the mammalian genome
Q24530537A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes
Q47985678A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene
Q47973727A silencer element in the regulatory region of glutamine synthetase controls cell type-specific repression of gene induction by glucocorticoids
Q35990792A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter.
Q28251967A small modulatory dsRNA specifies the fate of adult neural stem cells
Q55476243Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells.
Q37325255Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis
Q71070017Activity of the distal positive element of the peripherin gene is dependent on proteins binding to an Ets-like recognition site and a novel inverted repeat site
Q41243201Analysis of an alternative promoter that regulates tissue-specific expression of the human aromatic L-amino acid decarboxylase gene in cultured cell lines
Q58707891Analysis of the negative transcriptional regulatory element in the angiotensin-converting enzyme gene
Q43189963Arabidopsis co-repressor complexes containing polyamine oxidase-like proteins and plant-specific histone methyltransferases
Q71066513Asymmetric redundancy in CD4 silencer function
Q37484300Biological studies on alcohol-induced neuronal damage
Q36492575Brain selective transgene expression in zebrafish using an NRSE derived motif.
Q40926450Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter
Q48056565Cell type-specific regulation of choline acetyltransferase gene expression. Role of the neuron-restrictive silencer element and cholinergic-specific enhancer sequences
Q28201761Cell-type non-selective transcription of mouse and human genes encoding neural-restrictive silencer factor
Q42827629Characterization of 5' flanking region of alpha isoform of rat Ca2+/calmodulin-dependent protein kinase II gene and neuronal cell type specific promoter activity
Q40905109Characterization of the 5'-flanking region of the human dopamine transporter gene
Q52210076Characterization of the nicotinic acetylcholine receptor beta 3 gene. Its regulation within the avian nervous system is effected by a promoter 143 base pairs in length.
Q43726508Characterization of the rat GRIK5 kainate receptor subunit gene promoter and its intragenic regions involved in neural cell specificity
Q36673247Chicken tyrosine hydroxylase gene: isolation and functional characterization of the 5' flanking region.
Q28306534Chromatin crosstalk in development and disease: lessons from REST
Q36798006Cloning and characterization of the promoter for a potassium channel expressed in high frequency firing neurons
Q31932900Cloning from insulinoma cells of synapsin I associated with insulin secretory granules
Q24336509Cloning of human neuronatin gene and its localization to chromosome-20q 11.2-12: the deduced protein is a novel "proteolipid'
Q91845410CoRest1 regulates neurogenesis in a stage-dependent manner
Q34469236Comparative genomics of neuroglobin reveals its early origins
Q35426875Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo
Q33539513Control elements of muscarinic receptor gene expression.
Q28210913Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines
Q48183901Deletions of SCN1A 5' genomic region with promoter activity in Dravet syndrome.
Q40278363Detection of broadly expressed neuronal genes in C. elegans
Q40625759Distinct RE-1 silencing transcription factor-containing complexes interact with different target genes
Q40919305Dual tandem promoter elements containing CCAC-like motifs from the tetrodotoxin-resistant voltage-sensitive Na+ channel (rSkM2) gene can independently drive muscle-specific transcription in L6 cells.
Q38298672Endogenous retinoic acid receptor (RAR)-retinoid X receptor (RXR) heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes. Binding of ligands to RAR only is sufficient for RAR-RXR heterodimers
Q43112962Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain.
Q37157128Establishment of an intermittent cold stress model using Tupaia belangeri and evaluation of compound C737 targeting neuron-restrictive silencer factor
Q28360652Exonic Sp1 sites are required for neural-specific expression of the glycine receptor beta subunit gene
Q41133907Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer.
Q34188424Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP.
Q48795497Expression of the rat m4 muscarinic acetylcholine receptor gene is regulated by the neuron-restrictive silencer element/repressor element 1.
Q94544472From Neural Tube Formation Through the Differentiation of Spinal Cord Neurons: Ion Channels in Action During Neural Development
Q42801062Functional characterization of neural-restrictive silencer element in mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression
Q38705188Functional characterization of the neuron-restrictive silencer element in the human tryptophan hydroxylase 2 gene expression.
Q48072109Functional characterization of the promoter region of the mouse protein kinase C gamma gene
Q34642259Functional identification of the promoter for the gene encoding the alpha subunit of calcium/calmodulin-dependent protein kinase II.
Q44493199Gene transfer and in vivo promoter analysis of the rat progesterone receptor using a herpes simplex virus viral vector
Q28511419Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes
Q42824728Genomic organization and neuronal cell type specific promoter activity of beta isoform of Ca(2+)/calmodulin dependent protein kinase II of rat brain
Q38324169Genomic organization and regulatory elements of the rat latexin gene, which is expressed in a cell type-specific manner in both central and peripheral nervous systems
Q33714945Glucocorticoid control of glial gene expression
Q47681901Identification and characterization of a novel phorbol ester-responsive DNA sequence in the 5'-flanking region of the human dopamine beta-hydroxylase gene
Q36108580Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene
Q38298930Identification of a neurorestrictive suppressor element (NRSE) in the human mu-opioid receptor gene
Q73745105Identification of a novel repressive element that contributes to neuron-specific gene expression
Q36235133Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice
Q38352022Identification of cis-acting sequences in the promoter of the herpes simplex virus type 1 latency-associated transcripts required for activation by nerve growth factor and sodium butyrate in PC12 cells.
Q37366344Identification of potential target genes for the neuron-restrictive silencer factor
Q40183551Identification of the RA response element and transcriptional silencer in human alphaCaMKII promoter
Q38517920Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication
Q36925406Identification of the sensory neuron specific regulatory region for the mouse gene encoding the voltage-gated sodium channel NaV1.8.
Q28139329Identifying the promoter region of the human brain sodium channel subtype II gene (SCN2A)
Q46549735Implication of increased NRSF/REST binding activity in the mechanism of ethanol inhibition of neuronal differentiation
Q37033287Induction of neuronal and tumor-related genes by adenovirus type 12 E1A.
Q36516049Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors
Q24608490Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2
Q37728369Involvement of REST corepressor 3 in prognosis of human hepatitis B.
Q40861605Ion channels and early development of neural cells
Q74270314Is RE1/NRSE a common cis-regulatory sequence for ChAT and VAChT genes?
Q28567540Ischemic insults derepress the gene silencer REST in neurons destined to die
Q28117668Isolation and characterization of the 5'-upstream region of the human N-type calcium channel alpha1B subunit gene. Chromosomal localization and promoter analysis
Q28144735Isolation of the 5'-flanking region for human brain sodium channel subtype II alpha-subunit
Q44412157Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma
Q42595604Multiple regulatory elements mediating neuronal-specific expression of zebrafish sodium channel gene, scn8aa
Q47782310Multiplex DNA typing of short-tandem-repeat loci on the Y chromosome
Q72645721NF1-L is the DNA-binding component of the protein complex at the peripherin negative regulatory element
Q60946456NRSF and Its Epigenetic Effectors: New Treatments for Neurological Disease
Q24634087NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function
Q28213473NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region
Q46342935NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis
Q71965150Na+ channel β1 subunit mRNA: differential expression in rat spinal sensory neurons
Q34982387Negative regulatory elements upstream of a novel exon of the neuronal nicotinic acetylcholine receptor alpha 2 subunit gene
Q24644926Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes
Q41191861Neural specific expression of the m4 muscarinic acetylcholine receptor gene is mediated by a RE1/NRSE-type silencing element
Q44131114Neuron restrictive silencer factor as a modulator of neuropeptide gene expression
Q40523640Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
Q48227899Neuron-specific and developmental regulation of the synapsin II gene expression in transgenic mice
Q52538269Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region
Q38361779Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism
Q28579417Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene
Q40830529Neuronal restrictive silencing element is found in the KCC2 gene: molecular basis for KCC2-specific expression in neurons
Q41326226Neuronal-specific gene expression--the interaction of both positive and negative transcriptional regulators
Q28281904Normal huntingtin function: an alternative approach to Huntington's disease
Q33708478Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride
Q36682730Olf-1-binding site: characterization of an olfactory neuron-specific promoter motif
Q28473018Pain genes
Q35757133Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector
Q37205785Profiling RE1/REST-mediated histone modifications in the human genome
Q24522830Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element
Q82767062RE-1 silencer of transcription/neural restrictive silencer factor modulates ectodermal patterning during Xenopus development
Q37286540REST and the RESTless: in stem cells and beyond
Q33786618REST-VP16 activates multiple neuronal differentiation genes in human NT2 cells
Q24312038REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
Q37962572REST: transcriptional and epigenetic regulator.
Q42486058Regulation of DHP receptor expression by elements in the 5'-flanking sequence
Q30866082Regulation of GluR2 promoter activity by neurotrophic factors via a neuron-restrictive silencer element
Q40905120Regulation of NGFI-A (Egr-1) gene expression by the POU domain transcription factor Brn-3a
Q37995940Regulation of gene expression during early neuronal differentiation: evidence for patterns conserved across neuron populations and vertebrate classes
Q28214009Regulation of neuronal traits by a novel transcriptional complex
Q34080065Regulation of protocadherin gene expression by multiple neuron-restrictive silencer elements scattered in the gene cluster
Q40110899Regulation of tryptophan hydroxylase-2 gene expression by a bipartite RE-1 silencer of transcription/neuron restrictive silencing factor (REST/NRSF) binding motif
Q36769121Regulation of vertebrate corticotropin-releasing factor genes.
Q35346163Regulatory elements required for the activation and repression of the protocadherin-alpha gene cluster
Q40817335Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription
Q47883508Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus.
Q38339107Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease
Q38294213Retinal neuron activity of ETS domain-binding sites in a nicotinic acetylcholine receptor gene cluster enhancer
Q38304969Role of zinc finger domains of the transcription factor neuron-restrictive silencer factor/repressor element-1 silencing transcription factor in DNA binding and nuclear localization
Q41124377SEZ-6: promoter selectivity, genomic structure and localized expression in the brain.
Q34496614Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner.
Q48826387Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs
Q41987823Stepwise assembly of functional C-terminal REST/NRSF transcriptional repressor complexes as a drug target.
Q36790661Structure and expression of the mouse necdin gene. Identification of a postmitotic neuron-restrictive core promoter
Q41100185Structure of the m1 muscarinic acetylcholine receptor gene and its promoter
Q40750888Structure, function and expression of voltage-dependent sodium channels
Q73097330Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element
Q24290251Tau promoter confers neuronal specificity and binds Sp1 and AP-2
Q73472956The 5'2 promoter of the neuronal nitric oxide synthase dual promoter complex mediates inducibility by nerve growth factor
Q39175572The Importance of REST for Development and Function of Beta Cells
Q28275367The activity of a highly promiscuous AP-1 element can be confined to neurons by a tissue-selective repressive element
Q22253387The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex
Q48925369The human neuronal alpha 1-chimaerin gene contains a position-dependent negative regulatory element in the first exon
Q34413066The long arm of long noncoding RNAs: roles as sensors regulating gene transcriptional programs
Q41325976The molecular biology of preprotachykinin-A gene expression
Q42834207The mouse calretinin gene promoter region: structural and functional components
Q35984621The neural restrictive silencer element can act as both a repressor and enhancer of L1 cell adhesion molecule gene expression during postnatal development
Q33867569The neuron as a dynamic electrogenic machine: modulation of sodium-channel expression as a basis for functional plasticity in neurons
Q24550992The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes
Q36161198The neuron-restrictive silencer element: a dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain
Q24314740The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes
Q40402029The presence of both negative and positive elements in the 5'-flanking sequence of the rat Na,K-ATPase alpha 3 subunit gene are required for brain expression in transgenic mice
Q40964411The regulation of neuron-specific gene expression in the mammalian nervous system.
Q37603518The regulation of neuronal gene expression by alcohol.
Q24548294The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1)
Q38549906Tissue-specific enhancement and restriction of galanin gene expression in transgenic mice by 5' flanking sequences
Q30494551Tissue-specific expression of the L1 cell adhesion molecule is modulated by the neural restrictive silencer element
Q40945877Transcription of the human neuronal nitric oxide synthase gene in the central nervous system is mediated by multiple promoters
Q38296619Transcriptional analysis of acetylcholine receptor alpha 3 gene promoter motifs that bind Sp1 and AP2.
Q34354397Transcriptional channelopathies: an emerging class of disorders
Q24530710Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes
Q57660746Transcriptional regulation of gene expression of Sec6, a component of mammalian exocyst complex at the synapse
Q48029551Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements.
Q44987410Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor
Q36680865Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene.
Q28576708Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes
Q39584884Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex
Q41052151Transgenic and transcriptional studies on neurosecretory cell gene expression.
Q42454115Two E-boxes are the focal point of muscle-specific skeletal muscle type 1 Na+ channel gene expression
Q41175243Two alternative promoters direct neuron-specific expression of the rat microtubule-associated protein 1B gene
Q36556097Ubiquitous and neuronal DNA-binding proteins interact with a negative regulatory element of the human hypoxanthine phosphoribosyltransferase gene
Q41119843beta43': An enhancer displaying neural-restricted activity is located in the 3'-untranslated exon of the rat nicotinic acetylcholine receptor beta4 gene
Q38461882pUNISHER: a high-level expression cassette for use with recombinant viral vectors for rapid and long term in vivo neuronal expression in the CNS.

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