Characterization of a REST-Regulated Internal Promoter in the Schizophrenia Genome-Wide Associated Gene MIR137.

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Characterization of a REST-Regulated Internal Promoter in the Schizophrenia Genome-Wide Associated Gene MIR137. is …
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scholarly articleQ13442814

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P356DOI10.1093/SCHBUL/SBU117
P932PMC publication ID4393679
P698PubMed publication ID25154622
P5875ResearchGate publication ID265055025

P50authorGerome BreenQ47502400
Vivien BubbQ80493550
John P QuinnQ41818693
P2093author name stringDan Rujescu
Alix Warburton
P2860cites workA user's guide to the encyclopedia of DNA elements (ENCODE)Q21092716
Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targetsQ45263643
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The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophreniaQ48140110
Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models.Q48476430
Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han ChineseQ50312995
In vivo ChIP for the analysis of microdissected tissue samples.Q51544190
Modulation of orbitofrontal response to amphetamine by a functional variant of DAT1 and in vitro confirmation.Q51899449
Additive effect of BDNF and REST polymorphisms is associated with improved general cognitive abilityQ59853491
Mechanical stimulation induces preprotachykinin gene expression in osteoarthritic chondrocytes which is correlated with modulation of the transcription factor neuron restrictive silence factorQ59853552
Detection of small cell lung cancer by RT-PCR for neuropeptides, neuropeptide receptors, or a splice variant of the neuron restrictive silencer factorQ59853934
RE-1 silencing transcription factor-4 (REST4) is neither a transcriptional repressor nor a de-repressorQ77344451
YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disordersQ24298280
Dual role of NRSF/REST in activation and repression of the glucocorticoid responseQ24299730
REST: A mammalian silencer protein that restricts sodium channel gene expression to neuronsQ24312038
The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genesQ24314740
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1Q24630616
A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical markerQ28141839
Genome-wide association study identifies five new schizophrenia lociQ28248384
Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF)Q28250127
ENCODE data in the UCSC Genome Browser: year 5 updateQ28280234
Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genesQ28511419
Neuronal expression of zinc finger transcription factor REST/NRSF/XBR geneQ28579417
TRANSFAC: transcriptional regulation, from patterns to profilesQ29547394
rVISTA 2.0: evolutionary analysis of transcription factor binding sitesQ31081582
Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF.Q33767378
Cross talk between microRNA and epigenetic regulation in adult neurogenesisQ33788417
Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137.Q33924728
Genome-wide profiling of chromatin signatures reveals epigenetic regulation of MicroRNA genes in colorectal cancer.Q34198100
A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample.Q34574817
MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell linesQ34757887
A long AAAG repeat allele in the 5' UTR of the ERR-γ gene is correlated with breast cancer predisposition and drives promoter activity in MCF-7 breast cancer cellsQ36030812
A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryoQ36785035
Molecular genetics of monoamine transporters: relevance to brain disordersQ36981261
Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer elementQ38329948
Allele-specific transcriptional activity of the variable number of tandem repeats in 5' region of the DRD4 gene is stimulus specific in human neuronal cells.Q39271114
The SLC6A4 VNTR genotype determines transcription factor binding and epigenetic variation of this gene in response to cocaine in vitro.Q39594641
SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolutionQ39705556
The human neurokinin B gene, TAC3, and its promoter are regulated by Neuron Restrictive Silencing Factor (NRSF) transcription factor family.Q39836088
Differential regulation of the serotonin transporter gene by lithium is mediated by transcription factors, CCCTC binding protein and Y-box binding protein 1, through the polymorphic intron 2 variable number tandem repeatQ40158918
An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cellsQ40929859
REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activationQ42515237
Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia.Q43250022
Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger pronenessQ43572408
Neuron restrictive silencer factor as a modulator of neuropeptide gene expressionQ44131114
The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unitQ44287861
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectschizophreniaQ41112
P304page(s)698-707
P577publication date2014-08-25
P1433published inSchizophrenia BulletinQ4049133
P1476titleCharacterization of a REST-Regulated Internal Promoter in the Schizophrenia Genome-Wide Associated Gene MIR137.
P478volume41

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cites work (P2860)
Q36994815A GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression
Q92602807A VNTR Regulates miR-137 Expression Through Novel Alternative Splicing and Contributes to Risk for Schizophrenia
Q50015658A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.
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Q93047581Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling
Q55265504Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice.
Q35489742Meta gene set enrichment analyses link miR-137-regulated pathways with schizophrenia risk
Q34742694Molecular signatures of mood stabilisers highlight the role of the transcription factor REST/NRSF.
Q38283875NRSF: an angel or a devil in neurogenesis and neurological diseases
Q38727844Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus.
Q90272984Possible mechanisms of lycopene amelioration of learning and memory impairment in rats with vascular dementia
Q51418370Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology.
Q95327523Translational genomics and beyond in bipolar disorder
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Q91239726miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer
Q98182369miR-137: A Novel Therapeutic Target for Human Glioma
Q60958314microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease

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