A GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression

scientific article published on October 2015

A GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/SCHBUL/SBV144
P932PMC publication ID4903043
P698PubMed publication ID26429811
P5875ResearchGate publication ID282426206

P50authorGerome BreenQ47502400
John P QuinnQ41818693
P2093author name stringVivien J Bubb
Alix Warburton
P2860cites workValidation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targetsQ45263643
The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophreniaQ48140110
Human p53 tumor suppressor gene (TP53) and schizophrenia: case-control and family studies.Q51927765
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1Q24630616
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.Q27312392
The structure of haplotype blocks in the human genomeQ27860500
Genome-wide association study identifies five new schizophrenia lociQ28248384
Genome-wide association analysis identifies 13 new risk loci for schizophreniaQ28297287
HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variantsQ29614906
Cross talk between microRNA and epigenetic regulation in adult neurogenesisQ33788417
Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137.Q33924728
The role of p53 in neuronal cell deathQ34201989
A rare functional noncoding variant at the GWAS-implicated MIR137/MIR2682 locus might confer risk to schizophrenia and bipolar disorderQ34657883
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorderQ34658088
Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality MeasuresQ34696368
MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell linesQ34757887
Characterization of a REST-Regulated Internal Promoter in the Schizophrenia Genome-Wide Associated Gene MIR137.Q35369598
The p53 family in nervous system development and diseaseQ36521923
Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortexQ37120426
Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cellsQ37706529
MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene setsQ38989183
The human neurokinin B gene, TAC3, and its promoter are regulated by Neuron Restrictive Silencing Factor (NRSF) transcription factor family.Q39836088
Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137.Q43496188
Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participantsQ43515220
The miR-137 schizophrenia susceptibility variant rs1625579 does not predict variability in brain volume in a sample of schizophrenic patients and healthy individualsQ43898671
Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia.Q44121502
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectschizophreniaQ41112
genome-wide association studyQ1098876
P304page(s)1003-1008
P577publication date2015-10-01
P1433published inSchizophrenia BulletinQ4049133
P1476titleA GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression
P478volume42

Reverse relations

cites work (P2860)
Q50015658A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.
Q92395139A human minisatellite hosts an alternative transcription start site for NPRL3 driving its expression in a repeat number-dependent manner
Q57945283Association of With Symptom Severity and Cognitive Functioning in Belarusian Schizophrenia Patients
Q39031282Associations of microRNA single nucleotide polymorphisms and disease risk and pathophysiology
Q38806729Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future.
Q38952716MiR-137: an important player in neural development and neoplastic transformation.
Q38727844Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus.
Q60690261Regulatory variants: from detection to predicting impact
Q52654751The Regulation of Monoamine Oxidase A Gene Expression by Distinct Variable Number Tandem Repeats.
Q92286637Transgenic mice overexpressing miR-137 in the brain show schizophrenia-associated behavioral deficits and transcriptome profiles
Q61806070Treating the "E" in "G × E": Trauma-Informed Approaches and Psychological Therapy Interventions in Psychosis
Q60958314microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease