Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets

scientific article published on 20 December 2011

Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1043494035
P356DOI10.1038/MP.2011.170
P698PubMed publication ID22182936

P2093author name stringW Wang
E Kwon
L-H Tsai
P2860cites workDisrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signalingQ24322974
Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.Q24535773
MicroRNAs: target recognition and regulatory functionsQ24609584
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1Q24630616
Genome-wide association study identifies five new schizophrenia lociQ28248384
Whole-genome association study of bipolar disorderQ28271419
Cross talk between microRNA and epigenetic regulation in adult neurogenesisQ33788417
The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitorsQ35995825
Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brainQ48217502
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectschizophreniaQ41112
P304page(s)11-12
P577publication date2011-12-20
P1433published inMolecular PsychiatryQ6895973
P1476titleValidation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets
P478volume18

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cites work (P2860)
Q63869261A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
Q36994815A GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression
Q92602807A VNTR Regulates miR-137 Expression Through Novel Alternative Splicing and Contributes to Risk for Schizophrenia
Q50015658A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.
Q39026765A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137.
Q48348498A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity
Q34657883A rare functional noncoding variant at the GWAS-implicated MIR137/MIR2682 locus might confer risk to schizophrenia and bipolar disorder
Q42753490A survey of rare coding variants in candidate genes in schizophrenia by deep sequencing.
Q64112322Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients
Q37120426Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex
Q34177537Association of a miRNA-137 polymorphism with schizophrenia in a Southern Chinese Han population.
Q47828457Association study of schizophrenia with variants in miR-137 binding sites.
Q34458640Associations between DNA methylation and schizophrenia-related intermediate phenotypes - a gene set enrichment analysis
Q38189850Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128.
Q89113653Building a schizophrenia genetic network: transcription factor 4 regulates genes involved in neuronal development and schizophrenia risk
Q40643280CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector
Q37710652CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells
Q35369598Characterization of a REST-Regulated Internal Promoter in the Schizophrenia Genome-Wide Associated Gene MIR137.
Q60923952Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells
Q39127101Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population.
Q35731566Copy number variable microRNAs in schizophrenia and their neurodevelopmental gene targets
Q38384194Determining the role of microRNAs in psychiatric disorders
Q41819484Dissection of allelic interactions among Pto-miR257 and its targets and their effects on growth and wood properties in Populus
Q93047581Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling
Q35553863Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
Q50419804Dysregulation of miRNA and its potential therapeutic application in schizophrenia.
Q64076067Epigenetic Regulations in Neuropsychiatric Disorders
Q37496956Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders
Q33924728Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137.
Q47957465Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus
Q36837420Expression quantitative trait loci (eQTLs) in microRNA genes are enriched for schizophrenia and bipolar disorder association signals
Q89599083Focus on Causality in ESC/iPSC-Based Modeling of Psychiatric Disorders
Q35974121Genetic Evaluation of Schizophrenia Using the Illumina HumanExome Chip
Q40676388Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive meta-analysis
Q33949729Genetic architectures of psychiatric disorders: the emerging picture and its implications
Q34603780Genetic underpinnings of white matter 'connectivity': heritability, risk, and heterogeneity in schizophrenia
Q38268606Genetics in psychiatry
Q21261478Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1
Q97527612Genome-wide identification of methylated CpG sites in nongenital cutaneous warts
Q37505070Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells
Q93212905Genomic updates in understanding PTSD
Q38262765Genomics and epigenomics in novel schizophrenia drug discovery: translating animal models to clinical research and back.
Q95579811Genomics and the future of psychopharmacology: MicroRNAs offer novel therapeutics
Q34447816Heterogeneity and individuality: microRNAs in mental disorders
Q38751829Identification and Potential Regulatory Properties of Evolutionary Conserved Regions (ECRs) at the Schizophrenia-Associated MIR137 Locus.
Q33635688Large-scale interaction effects reveal missing heritability in schizophrenia, bipolar disorder and posttraumatic stress disorder.
Q52326263MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission.
Q38989183MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets
Q35489742Meta gene set enrichment analyses link miR-137-regulated pathways with schizophrenia risk
Q39002120MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls
Q38952716MiR-137: an important player in neural development and neoplastic transformation.
Q41554837MiRNAs of peripheral blood as the biomarker of schizophrenia
Q58785403Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells
Q35691087MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del.
Q37992401MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction
Q38227729MicroRNA-132, -134, and -138: a microRNA troika rules in neuronal dendrites
Q37363559MicroRNA-137 Inhibits EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients
Q39185826MicroRNA-137 regulates a glucocorticoid receptor-dependent signalling network: implications for the etiology of schizophrenia
Q33676705MicroRNA-9 and microRNA-326 regulate human dopamine D2 receptor expression, and the microRNA-mediated expression regulation is altered by a genetic variant
Q34394249MicroRNAs as the cause of schizophrenia in 22q11.2 deletion carriers, and possible implications for idiopathic disease: a mini-review
Q38843644MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Q38033846MicroRNAs shape the neuronal landscape
Q26744819MicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological Diseases
Q33627250Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
Q30442237Neurodevelopment in schizophrenia: the role of the wnt pathways
Q90114172Neurodevelopmental concepts of schizophrenia in the genome-wide association era: AKT/mTOR signaling as a pathological mediator of genetic and environmental programming during development
Q36067795No association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population.
Q34578760No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
Q26851626Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
Q92813967Novel Approaches for Identifying the Molecular Background of Schizophrenia
Q38103810Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription.
Q90406392Polymorphism in schizophrenia risk gene MIR137 is associated with the posterior cingulate Cortex's activation and functional and structural connectivity in healthy controls
Q36915423Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia
Q30454963Potential Impact of miR-137 and Its Targets in Schizophrenia
Q42934154Puzzling over schizophrenia: schizophrenia as a pathway disease
Q38260258Recent genetic findings in schizophrenia and their therapeutic relevance
Q35596962Schizophrenia miR-137 locus risk genotype is associated with dorsolateral prefrontal cortex hyperactivation
Q38057999TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease
Q94517766TS: a powerful truncated test to detect novel disease associated genes using publicly available gWAS summary data
Q52148949The Multifarious Hippocampal Functions of MicroRNA-137.
Q48140110The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia
Q34381708The genomics of schizophrenia: update and implications.
Q33923604The impact of MIR137 on dorsolateral prefrontal-hippocampal functional connectivity in healthy subjects
Q41002359The impact of genome wide supported microRNA-137 (MIR137) risk variants on frontal and striatal white matter integrity, neurocognitive functioning, and negative symptoms in schizophrenia.
Q91945137The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia
Q38450466The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function.
Q27312392The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Q58730340Tracing Early Neurodevelopment in Schizophrenia with Induced Pluripotent Stem Cells
Q38177652Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective.
Q37706529Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells
Q38979078Transcriptional targets of the schizophrenia risk gene MIR137.
Q35079675Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder
Q33940022Transcriptome-wide discovery of microRNA binding sites in human brain.
Q92286637Transgenic mice overexpressing miR-137 in the brain show schizophrenia-associated behavioral deficits and transcriptome profiles
Q35533016ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human Origin
Q38957856miR-137, a new target for post-stroke depression?
Q98182369miR-137: A Novel Therapeutic Target for Human Glioma
Q37645440miR-137: a new player in schizophrenia
Q92187683miRNA-Dependent Control of Homeostatic Plasticity in Neurons
Q36463734miRNA-mediated risk for schizophrenia in 22q11.2 deletion syndrome
Q60958314microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease

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