| scholarly article | Q13442814 |
| P50 | author | Albena Dinkova-Kostova | Q56806438 |
| Peter Canning | Q58203119 | ||
| P2093 | author name string | Rumen V Kostov | |
| P2860 | cites work | Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products | Q40616566 |
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| Validation of the multiple sensor mechanism of the Keap1-Nrf2 system | Q41962064 | ||
| AROMATIC-INDUCED PREVENTION OF FATAL TOXICITY OF 7,12-DIMETHYLBENZ[a]ANTHRACENE | Q42098050 | ||
| Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells | Q42435010 | ||
| Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein. | Q46467626 | ||
| Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane | Q46854767 | ||
| Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent. | Q46952116 | ||
| Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers | Q50897350 | ||
| Electrostatic influence of local cysteine environments on disulfide exchange kinetics | Q52732518 | ||
| Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex | Q53616483 | ||
| Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3-RINGBox1 protein complex and elucidation of its quaternary structure with Keap1. | Q54380424 | ||
| [Oxidative/electrophilic stress sensor Keap1 regulates the rapid turnover of transcripition factor Nrf2] | Q80145772 | ||
| Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1 | Q81309933 | ||
| Crystal structure of the BTB domain from PLZF | Q22003945 | ||
| Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex | Q24294734 | ||
| Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling | Q24298930 | ||
| Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8 | Q24299638 | ||
| The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 | Q24300456 | ||
| Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery | Q24302241 | ||
| Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases | Q24313433 | ||
| Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation | Q24314520 | ||
| Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase | Q24336527 | ||
| Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress | Q24555749 | ||
| Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex | Q24559743 | ||
| A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure | Q24562666 | ||
| The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila | Q24562764 | ||
| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 | Q24563807 | ||
| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain | Q24609907 | ||
| Cysteine-based regulation of the CUL3 adaptor protein Keap1 | Q24629359 | ||
| Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity | Q24655442 | ||
| Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction | Q24656061 | ||
| Notes from the Field: “Green” Chemoprevention as Frugal Medicine | Q27021094 | ||
| Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response | Q27647812 | ||
| Structural analysis of the complex of Keap1 with a prothymosin α peptide | Q27650252 | ||
| Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases | Q27657740 | ||
| A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases | Q27670841 | ||
| The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation | Q27675805 | ||
| Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases | Q27675990 | ||
| Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1 | Q27681060 | ||
| Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation | Q27682289 | ||
| Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO | Q27684072 | ||
| Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex | Q27689053 | ||
| The BACK domain in BTB-kelch proteins. | Q35950674 | ||
| Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome | Q35974394 | ||
| Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action. | Q36051913 | ||
| Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme | Q36086368 | ||
| Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. | Q36144939 | ||
| Keap1 degradation by autophagy for the maintenance of redox homeostasis | Q36187388 | ||
| INDUCED PROTECTION OF ADRENAL CORTEX AGAINST 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE. INFLUENCE OF ETHIONINE. INDUCTION OF MENADIONE REDUCTASE. INCORPORATION OF THYMIDINE-H3. | Q36266700 | ||
| Sites of alkylation of human Keap1 by natural chemoprevention agents | Q36282229 | ||
| Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. | Q36467640 | ||
| Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane | Q36557973 | ||
| Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism | Q36642707 | ||
| Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation | Q37101488 | ||
| Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex | Q37191843 | ||
| Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. | Q37398830 | ||
| Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation | Q37525077 | ||
| On the mechanisms of induction of cancer-protective enzymes: a unifying proposal | Q37558012 | ||
| Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway | Q37743477 | ||
| The cytoprotective role of the Keap1-Nrf2 pathway | Q37848718 | ||
| Toward clinical application of the Keap1–Nrf2 pathway | Q38105775 | ||
| The Nrf2 regulatory network provides an interface between redox and intermediary metabolism | Q38197467 | ||
| Monitoring Keap1-Nrf2 interactions in single live cells | Q38200391 | ||
| Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response. | Q38822665 | ||
| The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613. | Q39245992 | ||
| Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents | Q39358781 | ||
| SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. | Q39606140 | ||
| Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation | Q40403963 | ||
| The POZ domain: a conserved protein-protein interaction motif | Q28115868 | ||
| Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants | Q28218883 | ||
| An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements | Q28244853 | ||
| Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3 | Q28267411 | ||
| Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China | Q28281480 | ||
| Crystal structure of the Kelch domain of human Keap1 | Q28287182 | ||
| Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis | Q28385517 | ||
| Mechanism of chemical activation of Nrf2 | Q28482975 | ||
| Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China | Q28732170 | ||
| The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds | Q28755952 | ||
| Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model | Q28910182 | ||
| Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer | Q29616499 | ||
| The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase | Q29616502 | ||
| Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers | Q29616503 | ||
| Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress | Q29617845 | ||
| Prospective type 1 and type 2 disulfides of Keap1 protein. | Q30371642 | ||
| Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals | Q30497261 | ||
| Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish | Q30586026 | ||
| The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response | Q33586008 | ||
| Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis | Q33665840 | ||
| Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation | Q33707203 | ||
| Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains | Q33734064 | ||
| Small molecule modulators of antioxidant response pathway | Q33782967 | ||
| Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2 | Q33900511 | ||
| Electrophilic tuning of the chemoprotective natural product sulforaphane. | Q34006681 | ||
| Effects of dietary constituents on the metabolism of chemical carcinogens | Q34065979 | ||
| Chemoprotection against cancer by induction of phase 2 enzymes | Q34160772 | ||
| An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1 | Q34231986 | ||
| Glucosinolates and isothiocyanates in health and disease. | Q34274313 | ||
| Mechanism of Cullin3 E3 Ubiquitin Ligase Dimerization | Q34387857 | ||
| Sulforaphane treatment of autism spectrum disorder (ASD). | Q34442394 | ||
| Crystal structure of KLHL3 in complex with Cullin3 | Q34661978 | ||
| Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China | Q34790043 | ||
| Modification of keap1 cysteine residues by sulforaphane | Q34909588 | ||
| Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans | Q35680367 | ||
| The "Prochaska" microtiter plate bioassay for inducers of NQO1. | Q35718429 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | peptide | Q172847 |
| transcription factor | Q407384 | ||
| transport protein | Q2111029 | ||
| DNA-binding protein | Q2252764 | ||
| nuclear factor erythroid 2-related factor 2 | Q24788604 | ||
| P1104 | number of pages | 10 | |
| P304 | page(s) | 84-93 | |
| P577 | publication date | 2016-08-03 | |
| 2017-03-01 | |||
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Archives of Biochemistry and Biophysics | Q635818 |
| P1476 | title | Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants | |
| P478 | volume | 617 |
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| Q92422872 | Cannabidiol Regulates the Expression of Keratinocyte Proteins Involved in the Inflammation Process through Transcriptional Regulation |
| Q61449210 | Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages |
| Q91691679 | DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer |
| Q47888483 | Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties. |
| Q60920505 | Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance |
| Q57025204 | Evidence for Chemopreventive and resilience activity of licorice: Glycyrrhiza glabra and G. inflata extracts modulate estrogen metabolism in ACI rats |
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| Q89511236 | Identification of New Peptides from Fermented Milk Showing Antioxidant Properties: Mechanism of Action |
| Q99629125 | Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity |
| Q52723589 | Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. |
| Q49834826 | KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane |
| Q90720710 | Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity |
| Q91796591 | Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia⁻Reperfusion Injury by Activating Nrf2 Pathway |
| Q98391333 | Measuring Changes in Keap1-Nrf2 Protein Complex Conformation in Individual Cells by FLIM-FRET |
| Q43009709 | Nrf2 is highly expressed in neutrophils, but myeloid cell-derived Nrf2 is dispensable for wound healing in mice |
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