Crystal structure of KLHL3 in complex with Cullin3

scientific article

Crystal structure of KLHL3 in complex with Cullin3 is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2013PLoSO...860445J
P356DOI10.1371/JOURNAL.PONE.0060445
P932PMC publication ID3616122
P698PubMed publication ID23573258
P5875ResearchGate publication ID236189876

P2093author name stringGilbert G Privé
Alan X Ji
P2860cites workKelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms.Q53221890
BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligasesQ79120285
Crystal structure of the BTB domain from PLZFQ22003945
Molecular characterization of KLHL3, a human homologue of the Drosophila kelch geneQ22254240
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complexQ24294734
Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2Q24295274
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machineryQ24302241
Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled proteinQ24304286
Ubiquitin-dependent regulation of COPII coat size and functionQ24305964
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephronQ24307394
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer ProgressionQ24322269
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligaseQ24336527
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4Q24541348
I-TASSER: a unified platform for automated protein structure and function predictionQ24605680
A fully automatic evolutionary classification of protein folds: Dali Domain Dictionary version 3Q24605760
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domainQ24609907
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Sequence and structural analysis of BTB domain proteinsQ24812693
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligasesQ27626747
Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tailQ27635260
Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulatorQ27640942
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitinationQ27645983
Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin LigasesQ27657740
Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugatesQ27659805
Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1Q27661817
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activationQ27675805
Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin LigasesQ27675990
Inference of macromolecular assemblies from crystalline stateQ27860457
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutesQ27860502
Protein structure comparison by alignment of distance matricesQ27860798
Features and development of CootQ27861079
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Human hypertension caused by mutations in WNK kinasesQ28212182
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradationQ28302850
Toward rational protein crystallization: A Web server for the design of crystallizable protein variantsQ30441331
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenalsQ30497261
Molecular mechanisms of human hypertensionQ32138445
Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathyQ33944189
RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporterQ34085234
Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPA Receptor Endocytosis and Sorting PathwayQ34814366
Modification of keap1 cysteine residues by sulforaphaneQ34909588
Structural regulation of cullin-RING ubiquitin ligase complexesQ35151712
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.Q35740993
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalitiesQ35754537
K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertensionQ36019674
Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseasesQ36079020
Rabex-5 Protein Regulates the Endocytic Trafficking Pathway of Ubiquitinated Neural Cell Adhesion Molecule L1Q36294708
Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomesQ36906047
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.Q37398830
A family of LIC vectors for high-throughput cloning and purification of proteinsQ37408286
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolutionQ37830775
The cullin protein familyQ37873586
Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43.Q39343131
KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradationQ39748131
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.Q40633677
ProteinCCD: enabling the design of protein truncation constructs for expression and crystallization experimentsQ43103613
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphaneQ46854767
Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligasesQ50337002
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcrystal structureQ895901
P304page(s)e60445
P577publication date2013-04-03
P1433published inPLOS OneQ564954
P1476titleCrystal structure of KLHL3 in complex with Cullin3
P478volume8

Reverse relations

cites work (P2860)
Q36149053A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter
Q38742679Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells
Q36291365Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase
Q38626927Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population
Q35080292Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).
Q36159459Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia
Q37133559Cullin 3 as a novel target in diverse pathologies
Q47284253Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation.
Q40303257Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction.
Q47738355Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms
Q88993256Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo
Q36506665Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene
Q41728387KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.
Q64994328KLHL3 single-nucleotide polymorphism is associated with essential hypertension in Chinese Han population.
Q38916626KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination
Q38920601Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.
Q27678830Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases
Q64088977Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55
Q41980350New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases.
Q38383563Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
Q27682289Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation
Q38522152Structural basis of Keap1 interactions with Nrf2.
Q42694183Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases
Q27684072Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO
Q34043797Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation
Q37237987The integrated landscape of driver genomic alterations in glioblastoma

Search more.