Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).

scientific article published on 11 December 2014

Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.616664
P932PMC publication ID4326827
P698PubMed publication ID25505247
P5875ResearchGate publication ID269571977

P50authorEmil BulatovQ60393789
Frank SobottQ58010060
Paola GrandiQ28833289
P2093author name stringAxel Knebel
Satoko Shimamura
Albert Konijnenberg
Nico Zinn
Clare Johnson
Alessio Ciulli
Sneha Chatterjee
Esther M Martin
P2860cites workCullin-RING ubiquitin ligases: global regulation and activation cyclesQ21203558
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complexQ24294734
Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligaseQ24300948
Crystal structure of KLHL3 in complex with Cullin3Q34661978
Structural assembly of cullin-RING ubiquitin ligase complexesQ34762436
The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.Q34769739
Thermodynamics of structural stability and cooperative folding behavior in proteinsQ35533718
Heat capacity in proteinsQ36083067
Cullin 3 as a novel target in diverse pathologiesQ37133559
The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppressionQ37289267
The cullin protein familyQ37873586
Cullin-RING Ligases as Attractive Anti-cancer TargetsQ38059746
Native ion mobility-mass spectrometry and related methods in structural biologyQ38068027
Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?Q39812916
Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligasesQ40026609
Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells--evidence for cullin dimerizationQ40178983
F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18pQ41646870
Collision cross sections of proteins and their complexes: a calibration framework and database for gas-phase structural biologyQ42846188
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signalingQ44123776
The Dac-tag, an affinity tag based on penicillin-binding protein 5.Q50495118
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machineryQ24302241
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligasesQ24322407
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligaseQ24336527
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexesQ24337489
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexesQ24338109
Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalphaQ24554289
The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimerQ24685712
Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2pQ24804754
Building and remodelling Cullin-RING E3 ubiquitin ligasesQ27027816
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitinationQ27645983
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activationQ27675805
Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin LigasesQ27675990
Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin LigasesQ27679000
Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexesQ27685307
Structural basis of high-order oligomerization of the cullin-3 adaptor SPOPQ27685443
A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1pQ27939049
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitinationQ28143145
The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levelsQ28477287
SOCS2 negatively regulates growth hormone action in vitro and in vivoQ28508170
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfoldingQ29620340
Protein Structure and the Energetics of Protein Stability.Q30329721
Energetics of protein structure.Q30423369
Use of liquid hydrocarbon and amide transfer data to estimate contributions to thermodynamic functions of protein folding from the removal of nonpolar and polar surface from waterQ33211287
The ubiquitin system, disease, and drug discoveryQ33384295
Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substratesQ33857419
Nedd8 on cullin: building an expressway to protein destruction.Q33976667
Core-Binding Factor β Increases the Affinity between Human Cullin 5 and HIV-1 Vif within an E3 Ligase ComplexQ34034114
Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligaseQ34650624
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)4178-4191
P577publication date2014-12-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleBiophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).
P478volume290

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cites work (P2860)
Q38843472Applications of isothermal titration calorimetry - the research and technical developments from 2011 to 2015.
Q38380126Cell regulation by phosphotyrosine-targeted ubiquitin ligases
Q38673650Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex
Q90126260Degronomics: Mapping the Interacting Peptidome of a Ubiquitin Ligase Using an Integrative Mass Spectrometry Strategy
Q53465416Iron-sulfur proteins hiding in plain sight
Q59136768Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors
Q35677393Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.
Q54992503Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets.
Q64935699Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase.
Q34043797Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation
Q38608745The role of cullin proteins in gastric cancer
Q58051874Ubiquitin-Proteasome System: Promising Therapeutic Targets in Autoimmune and Neurodegenerative Diseases
Q55492703[The Role of SOCS in the Development of Tumors].

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