| scholarly article | Q13442814 |
| P50 | author | Fiona J Sorrell | Q58796185 |
| Peter Canning | Q58203119 | ||
| P2093 | author name string | Alex N Bullock | |
| P2860 | cites work | Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1 | Q81309933 |
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| A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells | Q24307672 | ||
| Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation | Q24314520 | ||
| Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase | Q24336527 | ||
| BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase | Q24558689 | ||
| Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex | Q24559743 | ||
| Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region | Q24563505 | ||
| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 | Q24563807 | ||
| Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway | Q24564882 | ||
| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain | Q24609907 | ||
| Cysteine-based regulation of the CUL3 adaptor protein Keap1 | Q24629359 | ||
| Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy | Q24652502 | ||
| Sequence and structural analysis of BTB domain proteins | Q24812693 | ||
| Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response | Q27647812 | ||
| Novel -Propeller of the BTB-Kelch Protein Krp1 Provides a Binding Site for Lasp-1 That Is Necessary for Pseudopodial Extension | Q27657284 | ||
| Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases | Q27657740 | ||
| Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases | Q27675990 | ||
| Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1 | Q27681060 | ||
| Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation | Q27682289 | ||
| Toward clinical application of the Keap1–Nrf2 pathway | Q38105775 | ||
| The Nrf2 regulatory network provides an interface between redox and intermediary metabolism | Q38197467 | ||
| Dimethyl fumarate in relapsing-remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety | Q38387687 | ||
| RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2. | Q39161771 | ||
| SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. | Q39606140 | ||
| Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products | Q40616566 | ||
| Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants | Q41724476 | ||
| New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases. | Q41980350 | ||
| Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles | Q44373729 | ||
| The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins. | Q52546379 | ||
| Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex | Q53616483 | ||
| Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO | Q27684072 | ||
| Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism | Q27684559 | ||
| Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes | Q27685307 | ||
| Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex | Q27689053 | ||
| The kelch repeat superfamily of proteins: propellers of cell function | Q28140778 | ||
| Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription | Q28202594 | ||
| Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants | Q28218883 | ||
| An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements | Q28244853 | ||
| Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron | Q28261724 | ||
| Crystal structure of the Kelch domain of human Keap1 | Q28287182 | ||
| Stress-activated cap'n'collar transcription factors in aging and human disease | Q28384783 | ||
| The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders | Q28395641 | ||
| Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer | Q28469051 | ||
| Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model | Q28910182 | ||
| Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression | Q29615644 | ||
| Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer | Q29616499 | ||
| The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase | Q29616502 | ||
| Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers | Q29616503 | ||
| Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress | Q29617845 | ||
| POZ for effect--POZ-ZF transcription factors in cancer and development | Q33258336 | ||
| Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. | Q33652512 | ||
| Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains | Q33734064 | ||
| Small molecule modulators of antioxidant response pathway | Q33782967 | ||
| Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2 | Q33900511 | ||
| Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase | Q34650624 | ||
| Crystal structure of KLHL3 in complex with Cullin3 | Q34661978 | ||
| Structural assembly of cullin-RING ubiquitin ligase complexes | Q34762436 | ||
| Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex | Q35152151 | ||
| Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. | Q35740993 | ||
| The BACK domain in BTB-kelch proteins. | Q35950674 | ||
| Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis | Q36172880 | ||
| Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention | Q36376887 | ||
| Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. | Q36467640 | ||
| Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. | Q36522434 | ||
| Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism | Q36642707 | ||
| Born to bind: the BTB protein-protein interaction domain. | Q36660566 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | Pt B | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | peptide | Q172847 |
| transcription factor | Q407384 | ||
| signal transduction | Q828130 | ||
| oxidative stress | Q898814 | ||
| DNA-binding protein | Q2252764 | ||
| biomedical investigative technique | Q66648976 | ||
| intracellular signaling peptides and proteins | Q67575047 | ||
| nuclear factor erythroid 2-related factor 2 | Q24788604 | ||
| P304 | page(s) | 101-107 | |
| P577 | publication date | 2015-06-07 | |
| 2015-11-01 | |||
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Free Radical Biology and Medicine | Q5500023 |
| P1476 | title | Structural basis of Keap1 interactions with Nrf2 | |
| P478 | volume | 88 |
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| Q90451937 | A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2 |
| Q36284103 | A targeted gene expression platform allows for rapid analysis of chemical-induced antioxidant mRNA expression in zebrafish larvae |
| Q37065083 | Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration |
| Q38745839 | Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis. |
| Q94073563 | Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling |
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| Q89511160 | Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-κB/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade |
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| Q59620601 | Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer |
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| Q95298719 | Development of an enzyme-linked immunosorbent assay for Keap1-Nrf2 interaction inhibitors identification |
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