Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model

scientific article published on 16 September 2019

Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11011-019-00488-Z
P698PubMed publication ID31529356

P50authorTim ClarnerQ90141242
P2093author name stringCordian Beyer
Stella Nyamoya
Adib Zendedel
Alexander Slowik
Christoph Wruck
Athanassios Fragoulis
Anna Nellessen
P2860cites workEffect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases.Q55036970
Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis.Q55467249
Oxidative stress and neuroinflammation should be both considered in the occurrence of fatigue and depression in multiple sclerosisQ62170851
Oxidative Stress Related to Iron Metabolism in Relapsing Remitting Multiple Sclerosis Patients With Low DisabilityQ64251070
Effect of cuprizone feeding on hepatic superoxide dismutase and cytochrome oxidase activities in miceQ72939941
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltrationQ79771601
G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination ModelsQ89004829
Effects of vitamin D on axonal damage during de- and remyelination in the cuprizone modelQ89344874
Cuprizone-induced graded oligodendrocyte vulnerability is regulated by the transcription factor DNA damage-inducible transcript 3Q90236939
Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and RemyelinationQ90346444
Mitochondrial Impairment in Oligodendroglial Cells Induces Cytokine Expression and SignalingQ90471272
Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 StabilizationQ90763980
Nrf2 Signaling in Sodium Azide-Treated Oligodendrocytes Restores Mitochondrial FunctionsQ91119964
Visualization of the Breakdown of the Axonal Transport Machinery: a Comparative Ultrastructural and Immunohistochemical ApproachQ91606284
Role of Nrf2 in oxidative stress and toxicityQ23919669
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complexQ24559743
Mitochondrial defects in acute multiple sclerosis lesionsQ24648580
Reactive oxygen species and mitochondria: A nexus of cellular homeostasisQ26782529
Oxidative stress and Parkinson's diseaseQ26798897
Mechanistic studies of the Nrf2-Keap1 signaling pathwayQ28277182
Effects of Fumaric Acids on Cuprizone Induced Central Nervous System De- and Remyelination in the MouseQ28750219
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and developmentQ29620011
Oligodendrocytes: biology and pathologyQ30051584
Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's diseaseQ30847085
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS releaseQ33913079
The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system.Q34122755
Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesionsQ34280654
Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: an overviewQ34667496
Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicityQ37236591
Import, maturation, and function of SOD1 and its copper chaperone CCS in the mitochondrial intermembrane spaceQ37724235
Structural basis of Keap1 interactions with Nrf2.Q38522152
Nrf2 in health and disease: current and future clinical implicationsQ38589464
Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation.Q38716944
Role of oxidative stress in Alzheimer's diseaseQ38819665
Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in miceQ40150004
Redox regulation of glial inflammatory response to lipopolysaccharide and interferongammaQ40533547
Protandim Protects Oligodendrocytes against an Oxidative InsultQ41202620
Response of glial cells to ischemia: roles of reactive oxygen species and glutathioneQ41377079
Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosumQ43807948
Mammalian SOD2 is exclusively located in mitochondria and not present in peroxisomes.Q44800193
Nrf2, a multi-organ protector?Q46572845
Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activationQ46707435
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone modelQ47118503
Chemical hypoxia-induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2).Q47325049
Cuprizone-Containing Pellets Are Less Potent to Induce Consistent Demyelination in the Corpus Callosum of C57BL/6 MiceQ48292000
Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model.Q48472483
Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stressQ48938738
Neurodegeneration Triggers Peripheral Immune Cell Recruitment into the ForebrainQ48945835
Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1.Q52927874
P433issue2
P304page(s)353-362
P577publication date2019-09-16
P1433published inMetabolic Brain DiseaseQ15764352
P1476titleNrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model
P478volume35

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cites work (P2860)
Q89772361A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain
Q91647353Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs
Q89617431Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit

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