| scholarly article | Q13442814 |
| review article | Q7318358 |
| P6179 | Dimensions Publication ID | 1000525154 |
| P356 | DOI | 10.1038/NRM1471 |
| P3181 | OpenCitations bibliographic resource ID | 770346 |
| P698 | PubMed publication ID | 15340381 |
| P5875 | ResearchGate publication ID | 8372941 |
| P50 | author | Michele Pagano | Q28357961 |
| P2093 | author name string | Timothy Cardozo | |
| P2860 | cites work | The F-box protein family. | Q21194893 |
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| Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts | Q24292464 | ||
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| Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome | Q24293506 | ||
| Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex | Q24294734 | ||
| E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1) | Q24296663 | ||
| Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling | Q24297062 | ||
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| Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase | Q24304123 | ||
| A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1 | Q24305471 | ||
| Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase | Q24306203 | ||
| Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1 | Q24322626 | ||
| M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP | Q24329203 | ||
| CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex | Q24336508 | ||
| Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex | Q24336704 | ||
| Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase | Q24529904 | ||
| An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin | Q24534109 | ||
| Small molecule modulation of Smoothened activity | Q24540343 | ||
| Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy | Q24555065 | ||
| Human cyclin F | Q24568186 | ||
| The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro | Q24608829 | ||
| Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase | Q24612979 | ||
| Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis | Q24680360 | ||
| Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation. | Q24800971 | ||
| The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts | Q35116922 | ||
| Cdc34 self-association is facilitated by ubiquitin thiolester formation and is required for its catalytic activity | Q35161788 | ||
| COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases | Q35541468 | ||
| When protein destruction runs amok, malignancy is on the loose | Q35571368 | ||
| Oncogenic aberrations of cullin-dependent ubiquitin ligases | Q35691547 | ||
| Ubiquitin ligases and the immune response | Q35698411 | ||
| Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins | Q36310068 | ||
| Structural basis of sugar-recognizing ubiquitin ligase | Q38344257 | ||
| Stability of homologue of Slimb F-box protein is regulated by availability of its substrate | Q38346254 | ||
| Dynamics of the cell cycle: checkpoints, sizers, and timers | Q40263208 | ||
| Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation | Q40431653 | ||
| BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. | Q40633677 | ||
| p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells | Q40918524 | ||
| The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. | Q40967633 | ||
| Cyclin E-CDK2 is a regulator of p27Kip1. | Q42800258 | ||
| Functional consequences of preorganized helical structure in the intrinsically disordered cell-cycle inhibitor p27(Kip1). | Q43853836 | ||
| Context of multiubiquitin chain attachment influences the rate of Sic1 degradation | Q44487504 | ||
| Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. | Q44587836 | ||
| A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. | Q46229708 | ||
| Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins | Q47068992 | ||
| The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. | Q47069071 | ||
| The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis | Q47069316 | ||
| Skp2-mediated degradation of p27 regulates progression into mitosis | Q47640200 | ||
| Proviral insertions in the zebrafish hagoromo gene, encoding an F-box/WD40-repeat protein, cause stripe pattern anomalies | Q47862533 | ||
| Basic Medical Research Award. The ubiquitin system | Q48372080 | ||
| Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases | Q50337002 | ||
| Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation | Q70995806 | ||
| Kip1 meets SKP2: new links in cell-cycle control | Q73177819 | ||
| Cooperative organization in a macromolecular complex | Q73747386 | ||
| Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases | Q77652490 | ||
| Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade | Q27620360 | ||
| Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases | Q27626747 | ||
| Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase | Q27640370 | ||
| Binding of small molecules to an adaptive protein-protein interface | Q27640488 | ||
| In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
| CDK inhibitors: positive and negative regulators of G1-phase progression | Q27860983 | ||
| The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. | Q27863647 | ||
| F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex | Q27934075 | ||
| SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box | Q27936367 | ||
| Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro | Q27938732 | ||
| A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p | Q27939049 | ||
| F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat | Q27939951 | ||
| p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 | Q28137813 | ||
| SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 | Q28137860 | ||
| The WD repeat: a common architecture for diverse functions | Q28143827 | ||
| The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase | Q28145635 | ||
| Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo | Q28177348 | ||
| Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis | Q28177893 | ||
| Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage | Q28182301 | ||
| Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines | Q28188140 | ||
| Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line | Q28188152 | ||
| Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex | Q28199187 | ||
| Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase | Q28202311 | ||
| The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27 | Q28202908 | ||
| Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation | Q28208407 | ||
| The leucine-rich repeat as a protein recognition motif | Q28212461 | ||
| Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase | Q28215069 | ||
| Three different binding sites of Cks1 are required for p27-ubiquitin ligation | Q28215946 | ||
| E3 ubiquitin ligase that recognizes sugar chains | Q28215953 | ||
| SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase | Q28234989 | ||
| Back to the future with ubiquitin | Q28240711 | ||
| Structural principles of leucine-rich repeat (LRR) proteins | Q28241151 | ||
| Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase | Q28249846 | ||
| Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex | Q28249855 | ||
| A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity | Q28343321 | ||
| Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins | Q28343954 | ||
| Dual mode of degradation of Cdc25 A phosphatase | Q28386155 | ||
| Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication | Q28507216 | ||
| A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant | Q28512070 | ||
| Identification of ubiquitin ligases required for skeletal muscle atrophy | Q28582211 | ||
| Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains | Q28590989 | ||
| Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation | Q28609667 | ||
| The anaphase-promoting complex: proteolysis in mitosis and beyond | Q28610045 | ||
| Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity | Q28910326 | ||
| p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding | Q28910366 | ||
| Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2 | Q28910370 | ||
| Proteasomes and their kin: proteases in the machine age | Q29614359 | ||
| Whose end is destruction: cell division and the anaphase-promoting complex | Q29618257 | ||
| Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy | Q29619282 | ||
| Recycling the Cell Cycle | Q29999767 | ||
| IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2. | Q30653145 | ||
| Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex | Q31038919 | ||
| Culprits in the degradation of cyclin E apprehended | Q33771904 | ||
| Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27 | Q33887383 | ||
| Nedd8 on cullin: building an expressway to protein destruction. | Q33976667 | ||
| Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27. | Q34141916 | ||
| Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. | Q34188705 | ||
| Split hand foot malformation is associated with a reduced level of Dactylin gene expression | Q34230565 | ||
| Mathematical modeling suggests cooperative interactions between a disordered polyvalent ligand and a single receptor site | Q34266710 | ||
| Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation. | Q34268195 | ||
| Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover | Q34277719 | ||
| A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). | Q34321355 | ||
| Protein-protein interfaces: mimics and inhibitors | Q34459889 | ||
| Inhibition of protein-protein association by small molecules: approaches and progress | Q34586778 | ||
| The spindle checkpoint: structural insights into dynamic signalling | Q34931754 | ||
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | molecular machine | Q2726733 |
| P304 | page(s) | 739-751 | |
| P577 | publication date | 2004-09-01 | |
| P1433 | published in | Nature Reviews Molecular Cell Biology | Q1573120 |
| P1476 | title | The SCF ubiquitin ligase: insights into a molecular machine | |
| P478 | volume | 5 |
| Q42459563 | "Cullin 4 makes its mark on chromatin". |
| Q28116106 | A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins |
| Q38242190 | A central role for ubiquitination within a circadian clock protein modification code |
| Q36781352 | A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation |
| Q33268297 | A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation |
| Q36684353 | A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis. |
| Q24529893 | A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons |
| Q36086942 | A genome-scale CRISPR-Cas9 screening method for protein stability reveals novel regulators of Cdc25A |
| Q90251589 | A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma |
| Q28477128 | A hybrid model of mammalian cell cycle regulation |
| Q48313988 | A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation |
| Q24317543 | A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation |
| Q37645217 | A novel F-box protein CaF-box is involved in responses to plant hormones and abiotic stress in pepper (Capsicum annuum L.). |
| Q40214592 | A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila |
| Q44218848 | A novel dRYBP-SCF complex functions to inhibit apoptosis in Drosophila |
| Q38313516 | A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control |
| Q38084210 | A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer |
| Q46032568 | A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch. |
| Q34517610 | A transcriptional activator is part of an SCF ubiquitin ligase to control degradation of its cofactors |
| Q33299579 | A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila |
| Q35027559 | A unique insertion in STARD9's motor domain regulates its stability |
| Q38891129 | APCCdh1 controls cell cycle entry during liver regeneration |
| Q41080453 | Abnormal retinal development in the Btrc null mouse |
| Q28744316 | Accelerated neuronal cell recovery from Botulinum neurotoxin intoxication by targeted ubiquitination |
| Q24292805 | Acetylation-dependent regulation of Skp2 function |
| Q27690825 | Actions of adenosine on cullin neddylation: implications for inflammatory responses |
| Q38075377 | Active modification of host inflammation by Salmonella |
| Q21245752 | Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor |
| Q37285218 | Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation |
| Q24620924 | Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery |
| Q37459809 | Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase |
| Q37983134 | Adenovirus degradation of cellular proteins. |
| Q43097731 | Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1. |
| Q49311835 | Akt regulates neurite growth by phosphorylation-dependent inhibition of radixin proteasomal degradation |
| Q39961194 | An AR-Skp2 pathway for proliferation of androgen-dependent prostate-cancer cells |
| Q24302459 | An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning |
| Q52340247 | An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis. |
| Q58700921 | Analysis of Drosophila melanogaster testis transcriptome |
| Q39507379 | Androgen receptor abnormalities in castration-recurrent prostate cancer |
| Q41872746 | Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation |
| Q46069083 | Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms |
| Q39820488 | Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. |
| Q35176196 | Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors |
| Q38161510 | Auxin and the ubiquitin pathway. Two players-one target: the cell cycle in action |
| Q34619941 | Auxin perception--structural insights |
| Q33811705 | BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans |
| Q51652979 | Backbone and side chain assignments of human cell cycle regulatory protein S-phase kinase-associated protein 1. |
| Q26863733 | Bacterial effectors and their functions in the ubiquitin-proteasome system: insight from the modes of substrate recognition |
| Q37336408 | Baculovirus F-box protein LEF-7 modifies the host DNA damage response to enhance virus multiplication |
| Q33756957 | Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases |
| Q37272000 | Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins. |
| Q41436188 | Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions |
| Q28594626 | Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems |
| Q24297410 | Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex |
| Q28290857 | CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation |
| Q34095647 | CKS1B nuclear expression is inversely correlated with p27Kip1 expression and is predictive of an adverse survival in patients with multiple myeloma |
| Q35828815 | CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms |
| Q57462865 | COP9 signalosome subunit 6 mediates PDGF -induced pulmonary arterial smooth muscle cells proliferation |
| Q42430485 | COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex |
| Q47309504 | COPS5 and LASP1 synergistically interact to downregulate 14-3-3σ expression and promote colorectal cancer progression via activating PI3K/AKT pathway. |
| Q38015388 | CRL Ubiquitin Ligases and DNA Damage Response |
| Q41060304 | CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation |
| Q34523341 | CSN6 drives carcinogenesis by positively regulating Myc stability. |
| Q33829502 | Calmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells |
| Q28395452 | Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis |
| Q53468657 | Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase. |
| Q37262174 | Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways |
| Q33793077 | Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin |
| Q35107397 | Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells. |
| Q34099819 | Cell biology. An ancient gauge for iron |
| Q47742875 | Cell cycle-dependent regulation of cytoglobin by Skp2. |
| Q38302730 | Characterization of the VIER F-BOX PROTEINE genes from Arabidopsis reveals their importance for plant growth and development. |
| Q64064765 | Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model |
| Q28509189 | Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression |
| Q35638236 | Clustering and negative feedback by endocytosis in planar cell polarity signaling is modulated by ubiquitinylation of prickle |
| Q46251971 | Comparative genomics of pathogenic and non-pathogenic beetle-vectored fungi in the genus Geosmithia |
| Q33306305 | Comparison of Petunia inflata S-Locus F-box protein (Pi SLF) with Pi SLF like proteins reveals its unique function in S-RNase based self-incompatibility |
| Q91272421 | Complete genome and bimodal genomic structure of the amoebal symbiont Neochlamydia strain S13 revealed by ultra-long reads obtained from MinION |
| Q34438089 | Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. |
| Q33870460 | Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis. |
| Q46950398 | Comprehensive ubiquitin E2 profiling of ten ubiquitin E3 ligases |
| Q33719500 | Contributions of neutrophils to resolution of mucosal inflammation |
| Q91924882 | Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions |
| Q34236497 | Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. |
| Q24647543 | Control of cell growth by the SCF and APC/C ubiquitin ligases |
| Q28273354 | Control of chromosome stability by the beta-TrCP-REST-Mad2 axis |
| Q24317234 | Control of iron homeostasis by an iron-regulated ubiquitin ligase |
| Q91297685 | Control of mTOR signaling by ubiquitin |
| Q56773250 | Control of plant germline proliferation by SCFFBL17 degradation of cell cycle inhibitors |
| Q36163600 | Controlling nuclear receptors: the circular logic of cofactor cycles |
| Q24294827 | Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling |
| Q37267450 | Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress |
| Q33259138 | Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo |
| Q39208674 | Crop-associated virus reduces the rooting depth of non-crop perennial native grass more than non-crop-associated virus with known viral suppressor of RNA silencing (VSR). |
| Q93127000 | Cucurbit Chlorotic Yellows Virus p22 Protein Interacts with Cucumber SKP1LB1 and Its F-Box-Like Motif Is Crucial for Silencing Suppressor Activity |
| Q34520002 | Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome |
| Q27935062 | Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing |
| Q36252935 | Cullin RING ligases: glommed by glomulin |
| Q24318748 | Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement |
| Q26746956 | Cullin-RING ligases in regulation of autophagy |
| Q24336569 | Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair |
| Q36796438 | Cyclins and cell cycle control in cancer and disease |
| Q38617375 | Cytogenetic Alterations in Multiple Myeloma: Prognostic Significance and the Choice of Frontline Therapy |
| Q33840856 | Cytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survival |
| Q89087700 | DEPTOR at the Nexus of Cancer, Metabolism, and Immunity |
| Q34075952 | DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation |
| Q92839040 | DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells |
| Q37518108 | Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila |
| Q56395221 | De Novo Variants in the F-Box Protein FBXO11 in 20 Individuals with a Variable Neurodevelopmental Disorder |
| Q36216079 | Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism |
| Q42547521 | Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling |
| Q24648025 | Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer |
| Q30278581 | Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis |
| Q40341932 | Derivitization of the C-terminus of ubiquitin and ubiquitin-like proteins using intein chemistry: methods and uses |
| Q35044801 | Development of inhibitors in the ubiquitination cascade |
| Q41895263 | Differential activation of ERK and Rac mediates the proliferative and anti-proliferative effects of hyaluronan and CD44. |
| Q54571506 | Differential response of multiple zebrafish hepatic F-box protein genes to 17alpha-ethinylestradiol treatment. |
| Q37004934 | Digital Gene Expression Analysis of Populus simonii × P. nigra Pollen Germination and Tube Growth |
| Q33862965 | Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development |
| Q53616483 | Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex. |
| Q60924153 | Direct binding of Cdt2 to PCNA is important for targeting the CRL4 E3 ligase activity to Cdt1 |
| Q38514605 | Discovery of candidate KEN-box motifs using cell cycle keyword enrichment combined with native disorder prediction and motif conservation |
| Q37579636 | Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2. |
| Q36684301 | Downregulation of vascular endothelial growth factor receptor-2 under oxidative stress conditions is mediated by β-transduction repeat-containing protein via glycogen synthase kinase-3β signaling |
| Q33228956 | Druggability of SCF ubiquitin ligase-protein interfaces |
| Q37899566 | Dynamic allostery: linkers are not merely flexible |
| Q27930260 | Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity. |
| Q47967824 | Dysregulated expression of SKP2 and its role in hematological malignancies |
| Q24316067 | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification |
| Q28389630 | E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia |
| Q34119372 | E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates |
| Q47636038 | E3 ubiquitin ligases in cancer and implications for therapies |
| Q39401307 | ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. |
| Q36210983 | ERα phosphorylation at Y537 by Src triggers E6-AP-ERα binding, ERα ubiquitylation, promoter occupancy, and target gene expression. |
| Q36740202 | Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligases |
| Q38954768 | Ectromelia virus encodes a family of Ankyrin/F-box proteins that regulate NFκB. |
| Q39953355 | Ectromelia virus encodes a novel family of F-box proteins that interact with the SCF complex |
| Q37410632 | Emerging therapies targeting the ubiquitin proteasome system in cancer |
| Q30492047 | Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer |
| Q36226432 | Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2 |
| Q34441649 | Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 |
| Q28740322 | Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate |
| Q43161201 | Essential role of Fbxl14 ubiquitin ligase in regulation of vertebrate axis formation through modulating Mkp3 level |
| Q34430770 | Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer |
| Q24299566 | Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing |
| Q37070653 | Evolution of F-box genes in plants: different modes of sequence divergence and their relationships with functional diversification |
| Q89393377 | Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer |
| Q54192918 | Expression of Sam68 Correlates With Cell Proliferation and Survival in Epithelial Ovarian Cancer. |
| Q34978849 | Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction |
| Q41521854 | Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M. |
| Q42272209 | F-Box Protein FBX92 Affects Leaf Size in Arabidopsis thaliana |
| Q24298563 | F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo |
| Q33985330 | F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6) |
| Q28396057 | F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest |
| Q28383185 | F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation |
| Q34227637 | F-box protein FBXO31 is down-regulated in gastric cancer and negatively regulated by miR-17 and miR-20a |
| Q36347238 | F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7 |
| Q34478774 | F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function |
| Q43986616 | F-box-like domains are present in most poxvirus ankyrin repeat proteins |
| Q36023053 | FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. |
| Q24314570 | FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51 |
| Q34382959 | FBW2 targets GCMa to the ubiquitin-proteasome degradation system |
| Q27010419 | FBW7-mediated ubiquitination and degradation of KLF5 |
| Q64087901 | FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progression |
| Q28396015 | FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest |
| Q34981648 | FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation |
| Q33809021 | FBXL21 association with schizophrenia in Irish family and case-control samples |
| Q24321496 | FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes |
| Q24307388 | FBXL5 interacts with p150Glued and regulates its ubiquitination |
| Q34313139 | FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response |
| Q24314409 | FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity |
| Q28594272 | FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas |
| Q24305093 | FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues |
| Q52423755 | FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1. |
| Q38945929 | FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine |
| Q36244404 | FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation |
| Q24297097 | FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy |
| Q64114238 | FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation |
| Q48094154 | FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system |
| Q35742526 | FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells |
| Q36489143 | Fbx8 makes Arf6 refractory to function via ubiquitination. |
| Q49322801 | Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity |
| Q64885697 | Fbxo41 Promotes Disassembly of Neuronal Primary Cilia. |
| Q28590633 | Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development |
| Q34317396 | Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation |
| Q42870285 | Fbxo45 joins the 'Par-4'ty in controlling apoptosis of cancer cells |
| Q35919057 | Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma |
| Q28591828 | Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development |
| Q39650269 | Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells |
| Q38029807 | Fulfilling the metabolic requirements for cell proliferation |
| Q28131707 | Function and regulation of cullin-RING ubiquitin ligases |
| Q26998944 | Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis |
| Q50026061 | Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer |
| Q33848408 | G protein-coupled receptor sorting to endosomes and lysosomes |
| Q37167678 | Gcm protein degradation suppresses proliferation of glial progenitors |
| Q38129455 | Gene networks controlling Arabidopsis thaliana flower development. |
| Q27027897 | Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases |
| Q33348860 | Genetics and cell biology of building specific synaptic connectivity |
| Q34770761 | Genetics and neurobiology of circadian clocks in mammals |
| Q37005459 | Genetics of circadian rhythms in Mammalian model organisms |
| Q33241222 | Genome of crocodilepox virus |
| Q39106050 | Genome-wide identification and characterisation of F-box family in maize |
| Q53471624 | Genomic stability and tumour suppression by the APC/C cofactor Cdh1. |
| Q36392344 | Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8. |
| Q36763544 | Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation |
| Q27345035 | GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1 |
| Q47235498 | Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway |
| Q79968436 | HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases |
| Q93380550 | Heat-induced inhibition of phosphorylation of the stress-protective transcription factor DREB2A promotes thermotolerance of Arabidopsis thaliana |
| Q36408600 | Heterochromatin assembly: a new twist on an old model |
| Q88011201 | Histone acetyltransferase CBP promotes function of SCF FBXL19 ubiquitin E3 ligase by acetylation and stabilization of its F-box protein subunit |
| Q36034566 | Holophytochrome-Interacting Proteins in Physcomitrella: Putative Actors in Phytochrome Cytoplasmic Signaling |
| Q36117812 | Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells |
| Q28756134 | Identification and characterization of lineage-specific genes within the Poaceae |
| Q27934529 | Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae |
| Q24302046 | Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication |
| Q24313153 | Identification of FBXO25-interacting proteins using an integrated proteomics approach |
| Q34874145 | Identification of SCF ubiquitin ligase substrates by global protein stability profiling |
| Q35171906 | Identification of SFBB-containing canonical and noncanonical SCF complexes in pollen of apple (Malus × domestica). |
| Q37030885 | Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. |
| Q53370309 | Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells. |
| Q24292985 | Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis |
| Q37435516 | Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras. |
| Q55260994 | Indole-3-carbinol: a plant hormone combatting cancer. |
| Q39031827 | Induction of Gsk3β-β-TrCP interaction is required for late phase stabilization of β-catenin in canonical Wnt signaling |
| Q53851410 | Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. |
| Q36066458 | Inhibition of S-phase kinase-associated protein 2 (Skp2) reprograms and converts diabetogenic T cells to Foxp3+ regulatory T cells |
| Q35562476 | Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice |
| Q35053454 | Insight into S-RNase-based self-incompatibility in Petunia: recent findings and future directions. |
| Q34474287 | Interaction and co-localization of JC virus large T antigen and the F-box protein β-transducin-repeat containing protein |
| Q36506566 | Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung |
| Q37117063 | Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana |
| Q34541185 | JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. |
| Q37238734 | JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation |
| Q41817100 | Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons. |
| Q92300589 | KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity |
| Q28385876 | LPS Impairs Phospholipid Synthesis by Triggering β-Transducin Repeat-containing Protein (β-TrCP)-mediated Polyubiquitination and Degradation of the Surfactant Enzyme Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (LPCAT1) |
| Q28385337 | LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1 |
| Q24301672 | Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom) |
| Q38186042 | Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy. |
| Q35859552 | Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase |
| Q36313828 | Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway |
| Q50516326 | Loci impacting polymorphic gait in the Tennessee Walking Horse. |
| Q41730755 | Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice |
| Q42425195 | MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models |
| Q39406924 | MYC Modulation around the CDK2/p27/SKP2 Axis |
| Q28469167 | Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint |
| Q37391843 | Male gametophyte development: a molecular perspective. |
| Q39705677 | Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress |
| Q36910294 | Mammalian iron metabolism and its control by iron regulatory proteins |
| Q36156706 | Mechanism of degradation of CPEB during Xenopus oocyte maturation |
| Q28394732 | Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease |
| Q27936984 | Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1. |
| Q37091856 | Melatonin signaling and its modulation of PfNF-YB transcription factor expression in Plasmodium falciparum. |
| Q35786021 | MiR-21: an environmental driver of malignant melanoma? |
| Q42408459 | Modification of Cul1 regulates its association with proteasomal subunits |
| Q37798551 | Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors |
| Q35641497 | Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells. |
| Q36836630 | Molecular changes induced by the curcumin analogue D6 in human melanoma cells |
| Q33474795 | Molecular characterization and tissue localization of an F-box only protein from silkworm, Bombyx mori |
| Q80480504 | Molecular characterization of axonemal proteins and signaling molecules responsible for chemoattractant-induced sperm activation in Ciona intestinalis |
| Q52606381 | Molecular characterization of the first saltwater crocodilepox virus genome sequences from the world's largest living member of the Crocodylia. |
| Q33665546 | Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligases |
| Q54233905 | Molecular dynamics simulations elucidate the mode of protein recognition by Skp1 and the F-box domain in the SCF complex. |
| Q48061418 | Molecular evolution and selection patterns of plant F-box proteins with C-terminal kelch repeats. |
| Q36593428 | Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia |
| Q37101488 | Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation |
| Q36267881 | Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. |
| Q26738906 | Multiple facets of p53 in senescence induction and maintenance |
| Q34612798 | Multisite phosphorylation of nuclear interaction partner of ALK (NIPA) at G2/M involves cyclin B1/Cdk1. |
| Q48135570 | Muscle-specific RING finger (MuRF) cDNAs in Atlantic salmon (Salmo salar) and their role as regulators of muscle protein degradation |
| Q28284058 | Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor |
| Q24311311 | Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1 |
| Q41218420 | NF-κB p65 Overexpression Promotes Bladder Cancer Cell Migration via FBW7-Mediated Degradation of RhoGDIα Protein |
| Q40322425 | Neddylation and CAND1 independently stimulate SCF ubiquitin ligase activity in Candida albicans |
| Q37150065 | Neddylation requires glycyl-tRNA synthetase to protect activated E2. |
| Q36074577 | Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase |
| Q48594214 | Neuronal expression of F-box and leucine-rich-repeat protein 2 decreases over Braak stages in the brains of Alzheimer's disease patients |
| Q26827177 | Neutrophils and inflammatory resolution in the mucosa |
| Q37182870 | New insights on the function of SCF ubiquitin E3 ligases in the lung |
| Q42218359 | Nongenomic Mechanisms of PTEN Regulation |
| Q35029570 | Nonstructural protein P7-2 encoded by Rice black-streaked dwarf virus interacts with SKP1, a core subunit of SCF ubiquitin ligase. |
| Q24304478 | Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest |
| Q58052434 | Novel components of germline sex determination acting downstream of foxl3 in medaka |
| Q46754499 | Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in Fatty Liver Shionogi mouse |
| Q37857958 | Novel functions for the anaphase-promoting complex in neurobiology. |
| Q27933960 | Novel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function |
| Q26773246 | Novel strategies to target the ubiquitin proteasome system in multiple myeloma |
| Q24337323 | Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner |
| Q34742737 | Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. |
| Q51451128 | OCT-4: a novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells. |
| Q42321596 | Oncogenic regulation of tumor metabolic reprogramming |
| Q41896926 | Orc2 protects ORCA from ubiquitin-mediated degradation |
| Q45065987 | Orchestrating the Specific Assembly of Centromeric Nucleosomes |
| Q33321261 | Origin and evolution of GALA-LRR, a new member of the CC-LRR subfamily: from plants to bacteria? |
| Q37098396 | Oskar is targeted for degradation by the sequential action of Par-1, GSK-3, and the SCF⁻Slimb ubiquitin ligase. |
| Q34175179 | Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance |
| Q47804391 | Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma |
| Q29616500 | Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1 |
| Q35552921 | Ozone-Induced Rice Grain Yield Loss Is Triggered via a Change in Panicle Morphology That Is Controlled by ABERRANT PANICLE ORGANIZATION 1 Gene. |
| Q94464887 | P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint |
| Q24304880 | PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity |
| Q24303881 | PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis |
| Q37267184 | PPARgamma-independent antitumor effects of thiazolidinediones |
| Q55395928 | PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions. |
| Q90251987 | PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain |
| Q38681448 | Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. |
| Q42616097 | Partial molecular characterization, expression pattern, polymorphism and association analysis of porcine SKP2 gene |
| Q38223676 | Pathways for genome integrity in G2 phase of the cell cycle |
| Q33762011 | Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation |
| Q28297156 | Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response |
| Q36063743 | Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets. |
| Q24602385 | Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction |
| Q24295177 | Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase |
| Q35943932 | Phosphorylation by p38 mitogen-activated protein kinase promotes estrogen receptor α turnover and functional activity via the SCF(Skp2) proteasomal complex |
| Q24309424 | Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase |
| Q28301467 | Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1 |
| Q35012953 | Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins |
| Q33813059 | Phylogenetic comparison of F-Box (FBX) gene superfamily within the plant kingdom reveals divergent evolutionary histories indicative of genomic drift |
| Q36155984 | Plant CULLIN-based E3s: phytohormones come first. |
| Q28115063 | Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression |
| Q24301123 | Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets |
| Q35676245 | Positive and negative regulation of Tetrahymena telomerase holoenzyme |
| Q26738654 | Post-Translational Regulation of miRNA Pathway Components, AGO1 and HYL1, in Plants |
| Q38159469 | Post-translational regulation of the cellular levels of DAPK. |
| Q28083265 | Poxviral ankyrin proteins |
| Q37945194 | Poxvirus exploitation of the ubiquitin-proteasome system |
| Q37157179 | Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor necrosis factor alpha but is independent of its host range function |
| Q33910672 | Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G. |
| Q36929118 | Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase |
| Q24294624 | Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death |
| Q38125901 | Proteasome-dependent degradation of replisome components regulates faithful DNA replication |
| Q38268314 | Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division |
| Q30413289 | Protein degradation and iron homeostasis |
| Q51404723 | Protein engineering strategies with potential applications for altering clinically relevant cellular pathways at the protein level. |
| Q40219805 | Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence |
| Q33447166 | Proteomic screening of variola virus reveals a unique NF-kappaB inhibitor that is highly conserved among pathogenic orthopoxviruses |
| Q27934263 | Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation |
| Q34518263 | RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner |
| Q90168118 | RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21 |
| Q24296350 | RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism |
| Q36729561 | Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex |
| Q34032707 | Rbx1 flexible linker facilitates cullin-RING ligase function before neddylation and after deneddylation |
| Q90390310 | Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL |
| Q39152605 | Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. |
| Q55365877 | Regulation of Aspergillus nidulans CreA-Mediated Catabolite Repression by the F-Box Proteins Fbx23 and Fbx47. |
| Q55239552 | Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System. |
| Q37995680 | Regulation of NF-κB by ubiquitination and degradation of the IκBs |
| Q34121488 | Regulation of Skp2 levels by the Pim-1 protein kinase |
| Q34987659 | Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications |
| Q27686867 | Regulation of abiotic stress signal transduction by E3 ubiquitin ligases in Arabidopsis |
| Q33675282 | Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex |
| Q34984389 | Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate |
| Q28577634 | Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons |
| Q36761432 | Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase |
| Q36124788 | Regulation of the protein stability of EMT transcription factors |
| Q21090530 | Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus |
| Q34125987 | Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction |
| Q45374159 | Ring structure amino acids affect the suppressor activity of melon aphid-borne yellows virus P0 protein |
| Q38813011 | Role of E3 ubiquitin ligases in insulin resistance |
| Q28508088 | Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis |
| Q33769567 | Role of individual subunits of the Neurospora crassa CSN complex in regulation of deneddylation and stability of cullin proteins |
| Q38289055 | Role of the ubiquitin proteasome system in hematologic malignancies. |
| Q40485246 | Role of unfolded protein response in plant virus infection |
| Q37923711 | Roles of COP9 signalosome in cancer. |
| Q36070012 | S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation |
| Q34146247 | SCF ensures meiotic chromosome segregation through a resolution of meiotic recombination intermediates |
| Q38267996 | SCF ubiquitin ligase-targeted therapies. |
| Q35754115 | SCF ubiquitin ligases in the maintenance of genome stability |
| Q37589134 | SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration |
| Q24337147 | SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation |
| Q36033829 | SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. |
| Q35228761 | SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer |
| Q41065965 | SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast |
| Q33930688 | SCF(SLF)-mediated cytosolic degradation of S-RNase is required for cross-pollen compatibility in S-RNase-based self-incompatibility in Petunia hybrida. |
| Q35087762 | SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells |
| Q36118305 | SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. |
| Q34073816 | SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication |
| Q104682651 | SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56 |
| Q50292291 | SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB |
| Q37340307 | SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. |
| Q38065012 | SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma |
| Q24677035 | SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis |
| Q24681845 | SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae |
| Q24302375 | SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1 |
| Q35838771 | SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function |
| Q24306820 | SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma |
| Q28588762 | SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression |
| Q24298620 | SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response |
| Q28505380 | SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release |
| Q37060597 | SKR-1, a homolog of Skp1 and a member of the SCF(SEL-10) complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans |
| Q38837458 | SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. |
| Q47616444 | SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent manner and regulates metastasis |
| Q39241517 | STYX: a versatile pseudophosphatase. |
| Q39939479 | Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box |
| Q36928968 | Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells |
| Q47229962 | Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis |
| Q27938009 | Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97. |
| Q37331347 | Silencing by small RNAs is linked to endosomal trafficking |
| Q34200869 | Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1 |
| Q28388125 | Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis |
| Q35972768 | Skp2 expression unfavorably impacts survival in resectable esophageal squamous cell carcinoma |
| Q42819481 | Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition |
| Q34341635 | Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity |
| Q39758487 | Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-beta responses |
| Q34318259 | Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer Targets |
| Q36600976 | Small molecule therapeutics targeting F-box proteins in cancer |
| Q38181445 | Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system |
| Q47069201 | Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination |
| Q24596988 | Specific small molecule inhibitors of Skp2-mediated p27 degradation |
| Q48594712 | Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission. |
| Q54580129 | Stability of F-box protein atrogin-1 is regulated by p38 mitogen-activated protein kinase pathway in cardiac H9c2 cells. |
| Q36867692 | State of the APC/C: organization, function, and structure |
| Q27676781 | Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5) |
| Q24300948 | Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase |
| Q47253133 | Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCFFBXO31 ubiquitin ligase |
| Q24314520 | Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation |
| Q27667443 | Structure and function of WD40 domain proteins |
| Q27657740 | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases |
| Q34575899 | Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization |
| Q38988485 | Sulforaphane suppresses LPS-induced or TPA-induced downregulation of PDCD4 in RAW 264.7 cells |
| Q52680513 | Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors. |
| Q28396388 | Sustained proliferation in cancer: Mechanisms and novel therapeutic targets |
| Q24561715 | Systematic analysis and nomenclature of mammalian F-box proteins |
| Q40180176 | TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation |
| Q40316450 | TIN2 stability is regulated by the E3 ligase Siah2. |
| Q36053266 | TRAF2: a double-edged sword? |
| Q36058634 | Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase. |
| Q64066924 | Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma |
| Q36215406 | Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells |
| Q39568509 | Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy |
| Q26866185 | Targeting the ubiquitin pathway for cancer treatment |
| Q39354978 | Teaching resources. Model of the TIR1 pathway for auxin-mediated gene expression |
| Q48827871 | The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors |
| Q92651169 | The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase |
| Q47113027 | The Arabidopsis thaliana F-box gene HAWAIIAN SKIRT is a new player in the microRNA pathway. |
| Q48086255 | The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis. |
| Q46665795 | The C-terminal domain of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1, is both necessary and sufficient for phosphorylation-independent proteolysis |
| Q24315928 | The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1 |
| Q24306576 | The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses |
| Q37255752 | The Drosophila IMD pathway in the activation of the humoral immune response. |
| Q52885335 | The E3 Ubiquitin Ligase CRL4 Regulates Proliferation and Progression Through Meiosis in Chinese Mitten Crab Eriocheir sinensis. |
| Q64230101 | The E3-ligases SCFPpa and APC/CCdh1 co-operate to regulate CENP-ACID expression across the cell cycle |
| Q37292195 | The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis |
| Q28301955 | The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition |
| Q24544148 | The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. |
| Q24310746 | The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress |
| Q50435820 | The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis |
| Q39478458 | The F-box family genes as key elements in response to salt, heavy mental, and drought stresses in Medicago truncatula. |
| Q24293991 | The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance |
| Q48403231 | The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt. |
| Q41898097 | The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein |
| Q36436025 | The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation. |
| Q24311644 | The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73 |
| Q53570311 | The F-box protein Fbp1 functions in the invasive growth and cell wall integrity mitogen-activated protein kinase (MAPK) pathways in Fusarium oxysporum. |
| Q28253006 | The F-box protein TIR1 is an auxin receptor |
| Q42122999 | The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis |
| Q90240183 | The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells |
| Q27695666 | The FP domains of PI31 and Fbxo7 have the same protein fold but very different modes of protein-protein interaction |
| Q38285213 | The Fanconi anemia ID2 complex: dueling saxes at the crossroads |
| Q36180722 | The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2. |
| Q37838484 | The Ime2 protein kinase family in fungi: more duties than just meiosis |
| Q28302850 | The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation |
| Q26784066 | The Non-Canonical Role of Aurora-A in DNA Replication |
| Q35583027 | The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin |
| Q38830141 | The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs |
| Q30430764 | The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein |
| Q52694987 | The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number. |
| Q36437659 | The SKP1-like gene family of Arabidopsis exhibits a high degree of differential gene expression and gene product interaction during development |
| Q45261017 | The Skp1 prolyl hydroxylase from Dictyostelium is related to the hypoxia-inducible factor-alpha class of animal prolyl 4-hydroxylases |
| Q38025378 | The Ubiquitin-Proteasome System and F-box Proteins in Pathogenic Fungi. |
| Q27932371 | The Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiae |
| Q24299799 | The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc |
| Q37479215 | The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCFCdc4. |
| Q40157700 | The adenovirus E4orf6 E3 ubiquitin ligase complex assembles in a novel fashion |
| Q38204953 | The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications |
| Q33858114 | The bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation |
| Q28584206 | The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration |
| Q30666963 | The coming of age of phosphoproteomics--from large data sets to inference of protein functions |
| Q24297104 | The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53 |
| Q38990058 | The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores. |
| Q36873556 | The cyclomodulin cycle inhibiting factor (CIF) alters cullin neddylation dynamics |
| Q37732529 | The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells |
| Q37307538 | The emerging role of the ubiquitin proteasome in pulmonary biology and disease |
| Q35081193 | The eukaryotic ancestor had a complex ubiquitin signaling system of archaeal origin |
| Q33324557 | The highly conserved orthopoxvirus 68k ankyrin-like protein is part of a cellular SCF ubiquitin ligase complex |
| Q39717057 | The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation |
| Q24324551 | The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation |
| Q39019840 | The immune signaling pathways of Manduca sexta |
| Q34509237 | The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae |
| Q47122092 | The intronic region of Fbxl12 functions as an alternative promoter regulated by UV irradiation |
| Q33508245 | The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation |
| Q40352974 | The nonreceptor tyrosine kinase c-Src attenuates SCF(β-TrCP) E3-ligase activity abrogating Taz proteasomal degradation. |
| Q27936227 | The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast |
| Q37204575 | The orthopoxvirus 68-kilodalton ankyrin-like protein is essential for DNA replication and complete gene expression of modified vaccinia virus Ankara in nonpermissive human and murine cells. |
| Q37546931 | The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis |
| Q30436067 | The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors |
| Q52725567 | The role of F-box only protein 31 in cancer. |
| Q54977935 | The role of Pdcd4 in tumor suppression and protein translation. |
| Q34852079 | The role of RING box protein 1 in mouse oocyte meiotic maturation |
| Q26849211 | The role of the ubiquitin-proteasome system in Agrobacterium tumefaciens-mediated genetic transformation of plants |
| Q35621438 | The scaffolding protein EBP50 promotes vascular smooth muscle cell proliferation and neointima formation by regulating Skp2 and p21(cip1). |
| Q34749877 | The specificities of Kaposi's sarcoma-associated herpesvirus-encoded E3 ubiquitin ligases are determined by the positions of lysine or cysteine residues within the intracytoplasmic domains of their targets |
| Q41545354 | The stability of Fbw7α in M-phase requires its phosphorylation by PKC. |
| Q47447345 | The transcriptional regulation of protein complexes; a cross-species perspective |
| Q38087182 | The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer |
| Q34801426 | The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity |
| Q36400535 | The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei |
| Q28305844 | The ubiquitin-proteasome system |
| Q24336640 | The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival |
| Q37807639 | The ubiquitous role of ubiquitin in the DNA damage response |
| Q46405731 | The unfolded protein response is triggered by a plant viral movement protein |
| Q33364824 | The vascular plants: open system of growth |
| Q37591349 | The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor |
| Q64062471 | Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila |
| Q34225698 | Twists and turns in ubiquitin-like protein conjugation cascades |
| Q34750255 | Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle. |
| Q38743981 | Tyrosine phosphorylation modulates mitochondrial chaperonin Hsp60 and delays rotavirus NSP4-mediated apoptotic signaling in host cells |
| Q62799363 | USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression |
| Q37635847 | Ubiquibodies, synthetic E3 ubiquitin ligases endowed with unnatural substrate specificity for targeted protein silencing |
| Q36601000 | Ubiquitin and ubiquitin-like proteins in cancer pathogenesis |
| Q34503492 | Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets |
| Q24320275 | Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation |
| Q37661565 | Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity |
| Q24298681 | Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells |
| Q39900436 | Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins. |
| Q26998402 | Ubiquitin ligases in cholesterol metabolism |
| Q38234883 | Ubiquitin pathways in neurodegenerative disease |
| Q101140335 | Ubiquitin signaling in cell cycle control and tumorigenesis |
| Q24323309 | Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation |
| Q27931359 | Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion |
| Q28274205 | Ubiquitination and degradation of the inhibitors of NF-kappaB |
| Q38229325 | Ubiquitination involved enzymes and cancer |
| Q35922462 | Ubiquitination of BST-2 protein by HIV-1 Vpu protein does not require lysine, serine, or threonine residues within the BST-2 cytoplasmic domain |
| Q38021448 | Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications |
| Q37637735 | Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains |
| Q36455676 | Understanding cullin-RING E3 biology through proteomics-based substrate identification |
| Q42196272 | Unique role for the UbL-UbA protein Ddi1 in turnover of SCFUfo1 complexes |
| Q38047273 | Unraveling the ubiquitin-regulated signaling networks by mass spectrometry-based proteomics. |
| Q40271317 | Up-regulation of Skp2 after prostate cancer cell adhesion to basement membranes results in BRCA2 degradation and cell proliferation |
| Q57296976 | Upregulation Predicts a Poor Prognosis and Associates with a Possible Mechanism for Paclitaxel Resistance in Ovarian Cancer |
| Q43956916 | Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition |
| Q38168896 | Using proteomics to identify the HBx interactome in hepatitis B virus: how can this inform the clinic? |
| Q39340936 | WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells |
| Q36562711 | Will you let me use your nucleus? How Agrobacterium gets its T-DNA expressed in the host plant cell. |
| Q33307883 | Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes |
| Q33793960 | alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells |
| Q39792638 | beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. |
| Q35585170 | hUbiquitome: a database of experimentally verified ubiquitination cascades in humans |
| Q28251026 | mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR |
| Q28251047 | mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR |
| Q39373595 | miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1. |
| Q58568561 | miR‑27a promotes human breast cancer cell migration by inducing EMT in a FBXW7‑dependent manner |
| Q98384399 | β-TrCP suppresses the migration and invasion of trophoblast cells in preeclampsia by down-regulating Snail |
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