| scholarly article | Q13442814 |
| P50 | author | Peter Howley | Q2075824 |
| P2093 | author name string | G Wang | |
| N P Pavletich | |||
| L Huang | |||
| J M Huibregtse | |||
| S Beaudenon | |||
| E Kinnucan | |||
| P2860 | cites work | Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination | Q26778405 |
| P433 | issue | 5443 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | protein ubiquitination | Q3547638 |
| P1104 | number of pages | 6 | |
| P304 | page(s) | 1321-1326 | |
| P577 | publication date | 1999-11-01 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade | |
| P478 | volume | 286 |
| Q77445654 | 1H, 15N and 13C assignments of the catalytic domain of E6-associated protein (E6AP) |
| Q36858585 | A Drosophila model for Angelman syndrome |
| Q39438764 | A Genomic Survey of HECT Ubiquitin Ligases in Eukaryotes Reveals Independent Expansions of the HECT System in Several Lineages |
| Q24291047 | A HECT domain E3 enzyme assembles novel polyubiquitin chains |
| Q27658641 | A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities |
| Q27704870 | A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes |
| Q78761236 | A closer look of the HECTic ubiquitin ligases |
| Q24336529 | A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system |
| Q42321543 | A conformational switch regulates the ubiquitin ligase HUWE1. |
| Q39927831 | A conserved catalytic residue in the ubiquitin-conjugating enzyme family. |
| Q35800274 | A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase |
| Q27678628 | A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease |
| Q30422755 | A pathogen type III effector with a novel E3 ubiquitin ligase architecture |
| Q38084210 | A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer |
| Q24303664 | A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 |
| Q24306428 | ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor |
| Q38829124 | Activity-Based Probes for HECT E3 Ubiquitin Ligases |
| Q48178072 | Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch. |
| Q28591808 | Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system |
| Q28207621 | An NMR-based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2.Ubc13. The structural basis for lysine 63 chain catalysis |
| Q24314049 | An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair |
| Q52130370 | Analysis of peripheral amyloid precursor protein in Angelman Syndrome |
| Q64229270 | Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity |
| Q35811797 | Angelman Syndrome. |
| Q91782531 | Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome |
| Q42173312 | Angelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome |
| Q24678174 | Angelman syndrome: a review of the clinical and genetic aspects |
| Q38028343 | Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages |
| Q28240711 | Back to the future with ubiquitin |
| Q33518531 | Bi-directional SIFT predicts a subset of activating mutations |
| Q39405512 | Bimolecular Fluorescence Complementation to Assay the Interactions of Ubiquitylation Enzymes in Living Yeast Cells |
| Q44985714 | Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein. |
| Q27665390 | Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7 |
| Q35925045 | Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-Linkers |
| Q34170979 | Cell cycle regulatory E3 ubiquitin ligases as anticancer targets. |
| Q42602705 | Characterization of the human UBE3B gene: structure, expression, evolution, and alternative splicing |
| Q39034333 | Clinical significance of the ubiquitin ligase UBE3C in hepatocellular carcinoma revealed by exome sequencing. |
| Q34589737 | Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z). |
| Q30363206 | Comparative analysis of protein structure alignments |
| Q90440580 | Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases |
| Q46950398 | Comprehensive Ubiquitin E2 Profiling of Ten Ubiquitin E3 Ligases |
| Q33991441 | Computational design of second-site suppressor mutations at protein-protein interfaces |
| Q24292829 | Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase |
| Q24539123 | Control of biochemical reactions through supramolecular RING domain self-assembly |
| Q34634239 | Convergent evolution in the assembly of polyubiquitin degradation signals by the Shigella flexneri IpaH9.8 ligase |
| Q34012276 | Creation of a pluripotent ubiquitin-conjugating enzyme |
| Q27649240 | Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase |
| Q27677106 | Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions |
| Q35978862 | DNA postreplication repair modulated by ubiquitination and sumoylation. |
| Q58837454 | Developing Small-Molecule Inhibitors of HECT-Type Ubiquitin Ligases for Therapeutic Applications: Challenges and Opportunities |
| Q35044801 | Development of inhibitors in the ubiquitination cascade |
| Q42160240 | Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis |
| Q35207883 | Drug discovery in the ubiquitin regulatory pathway |
| Q36525810 | Drug discovery in the ubiquitin-proteasome system. |
| Q35643657 | E1-E2 Interactions in Ubiquitin and Nedd8 Ligation Pathways |
| Q35065158 | E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP. |
| Q28270616 | E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer |
| Q26752818 | E2 enzymes: more than just middle men |
| Q24293777 | E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages |
| Q28301074 | E2s: structurally economical and functionally replete |
| Q24293302 | E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1) |
| Q37146105 | E6-associated protein (E6-AP) is a dual function coactivator of steroid hormone receptors |
| Q38148981 | E6AP in the brain: one protein, dual function, multiple diseases |
| Q36760286 | E6AP/UBE3A Ubiquitin Ligase Harbors Two E2∼ubiquitin Binding Sites |
| Q33727624 | Engineering a protein–protein interface using a computationally designed library |
| Q92105561 | Enzymatic Logic of Ubiquitin Chain Assembly |
| Q30373162 | Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders. |
| Q81453927 | Expression and assay of HECT domain ligases |
| Q27937365 | Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p |
| Q26781685 | From UBE3A to Angelman syndrome: a substrate perspective |
| Q24649733 | G2E3 is a dual function ubiquitin ligase required for early embryonic development |
| Q34433463 | Genome Organization, Function, and Imprinting in Prader-Willi and Angelman Syndromes |
| Q35681247 | Getting into position: the catalytic mechanisms of protein ubiquitylation |
| Q37330142 | HACE1: A novel repressor of RAR transcriptional activity. |
| Q64080057 | HECT E3 Ligases: A Tale With Multiple Facets |
| Q30444132 | HECT E3s and human disease |
| Q24599672 | HECT and RING finger families of E3 ubiquitin ligases at a glance |
| Q36321265 | HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway |
| Q33384291 | HPV E6, E6AP and cervical cancer |
| Q90589761 | HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53 |
| Q40170945 | Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. |
| Q24647624 | Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligases |
| Q41512792 | Human papillomavirus 16 E6 is associated with the nuclear matrix of esophageal carcinoma cells |
| Q33962694 | Human papillomavirus immortalization and transformation functions |
| Q33807681 | Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase |
| Q35774953 | Human proteome-scale structural modeling of E2-E3 interactions exploiting interface motifs |
| Q24551145 | Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase |
| Q30857842 | Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugation |
| Q41818024 | Identification of a non-covalent ternary complex formed by PIAS1, SUMO1, and UBC9 proteins involved in transcriptional regulation |
| Q34112326 | Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex |
| Q28118367 | Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase |
| Q77231665 | Identification of molecular determinants required for interaction of ubiquitin‐conjugating enzymes and RING finger proteins |
| Q24624622 | Identification, analysis, and prediction of protein ubiquitination sites |
| Q47097673 | Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer |
| Q47682400 | In silico modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly |
| Q34628709 | In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae |
| Q36298696 | Inhibiting the Protein Ubiquitination Cascade by Ubiquitin-Mimicking Short Peptides |
| Q109422760 | Inhibition of HECT E3 ligases as potential therapy for COVID-19 |
| Q29617624 | Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex |
| Q27658921 | Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex |
| Q56534684 | Insights into the ubiquitin transfer cascade catalyzed by the effector SidC |
| Q34185334 | Interaction between HERC1 and M2-type pyruvate kinase |
| Q24290986 | Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes |
| Q73436372 | Interaction of the tail with the catalytic region of a class II E2 conjugating enzyme |
| Q42378976 | Involvement of Ubiquitin-Conjugating Enzyme (E2 Gene Family) in Ripening Process and Response to Cold and Heat Stress of Vitis vinifera |
| Q36917433 | It takes two to tango: Ubiquitin and SUMO in the DNA damage response |
| Q36093065 | Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation |
| Q90440759 | KIAA0317 regulates pulmonary inflammation through SOCS2 degradation |
| Q33559052 | Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway |
| Q34782977 | Macromolecular juggling by ubiquitylation enzymes |
| Q34336329 | Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects |
| Q36630645 | Measuring Rates of Ubiquitin Chain Formation as a Functional Readout of Ligase Activity |
| Q28067393 | Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 |
| Q27679532 | Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 |
| Q34230579 | Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases |
| Q34085131 | Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway |
| Q27663996 | Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4 |
| Q35738601 | Molecular Mechanisms of Ubiquitin-Dependent Membrane Traffic |
| Q36006585 | Molecular and Clinical Aspects of Angelman Syndrome |
| Q27633059 | Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer |
| Q27937366 | Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. |
| Q38248435 | Mutation Update for UBE3A variants in Angelman syndrome |
| Q28284058 | Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor |
| Q37378038 | Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia |
| Q27653225 | NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway |
| Q24651528 | Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions |
| Q38201970 | New insights into ubiquitin E3 ligase mechanism |
| Q24336899 | Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7 |
| Q57027942 | Oligomerization of the Hect ubiquitin ligase Nedd4-2/NEDD4L is essential for polyubiquitin chain assembly |
| Q33924565 | Orthogonal Ubiquitin Transfer through Engineered E1-E2 Cascades for Protein Ubiquitination |
| Q36571577 | Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel |
| Q34601308 | Peptide and small molecule inhibitors of HECT-type ubiquitin ligases |
| Q28306492 | Perilous journey: a tour of the ubiquitin-proteasome system |
| Q47322523 | Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase |
| Q35010932 | Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2 |
| Q29617293 | Physiological functions of the HECT family of ubiquitin ligases |
| Q34992787 | Polyreactivity and autoreactivity among HIV-1 antibodies |
| Q37233382 | Polyubiquitination by HECT E3s and the determinants of chain type specificity |
| Q36992786 | Potential therapeutic approaches for Angelman syndrome |
| Q39789707 | Prediction of lysine ubiquitination with mRMR feature selection and analysis |
| Q39940469 | Pressure-Induced Differential Regulation of the Two Tryptophan Permeases Tat1 and Tat2 by Ubiquitin Ligase Rsp5 and Its Binding Proteins, Bul1 and Bul2 |
| Q89925905 | Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond |
| Q37168597 | Protein interactions in the sumoylation cascade: lessons from X-ray structures |
| Q33580119 | Protein post-translational modifications: In silico prediction tools and molecular modeling |
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| Q24299749 | Proteolytic Targeting of Transcriptional Regulator TIP120B by a HECT Domain E3 Ligase |
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| Q24273416 | Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase |
| Q64992613 | Regulating the human HECT E3 ligases. |
| Q89793532 | Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly |
| Q36714155 | Regulation of catalytic activities of HECT ubiquitin ligases |
| Q27938247 | Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site |
| Q44587836 | Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. |
| Q26827979 | Role of E2-Ub-conjugating enzymes during skeletal muscle atrophy |
| Q26744849 | Role of Ubiquitin-Mediated Degradation System in Plant Biology |
| Q35961196 | Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination |
| Q24302375 | SCFFBXL15regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1 |
| Q24320238 | SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage |
| Q57979697 | SUMO modification of the ubiquitin-conjugating enzyme E2-25K |
| Q27936615 | SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p. |
| Q41612152 | Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1. |
| Q42420223 | Sequence determinants of E2-E6AP binding affinity and specificity |
| Q34438710 | Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1 |
| Q45029738 | Solution structure of the flexible class II ubiquitin-conjugating enzyme Ubc1 provides insights for polyubiquitin chain assembly. |
| Q38728113 | Specificity and disease in the ubiquitin system |
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| Q27675352 | Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica |
| Q47552384 | Structural Insights in Multifunctional Papillomavirus Oncoproteins. |
| Q83477572 | Structural Insights into Functional Modes of Proteins Involved in Ubiquitin Family Pathways |
| Q27678872 | Structural Insights into the Conformation and Oligomerization of E2∼Ubiquitin Conjugates |
| Q27638680 | Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10 |
| Q33987001 | Structural and functional insights to ubiquitin-like protein conjugation. |
| Q27637899 | Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1 |
| Q27640370 | Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase |
| Q24293794 | Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1 |
| Q40373215 | Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. |
| Q35052128 | Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. |
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| Q27640661 | Structural insights into the U-box, a domain associated with multi-ubiquitination |
| Q38916854 | Structural insights into the catalysis and regulation of E3 ubiquitin ligases |
| Q27667265 | Structure and function of a HECT domain ubiquitin‐binding site |
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| Q27678298 | Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism |
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| Q27652851 | Structure of a Shigella effector reveals a new class of ubiquitin ligases |
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| Q27635260 | Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail |
| Q36291328 | Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases. |
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| Q27673792 | Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase |
| Q41628192 | Structure of the HECT domain of human WWP2. |
| Q27667262 | Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation |
| Q27680020 | Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase |
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| Q44765720 | The -4 phenylalanine is required for substrate ubiquitination catalyzed by HECT ubiquitin ligases |
| Q61730550 | The Arabidopsis KAKTUS gene encodes a HECT protein and controls the number of endoreduplication cycles |
| Q64078884 | The Autism and Angelman Syndrome Protein Ube3A/E6AP: The Gene, E3 Ligase Ubiquitination Targets and Neurobiological Functions |
| Q36791340 | The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance |
| Q36154748 | The E3 ubiquitin ligase RNF135 regulates the tumorigenesis activity of tongue cancer SCC25 cells |
| Q37348923 | The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates. |
| Q33553868 | The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognition |
| Q37206488 | The HECT family of E3 ubiquitin ligases: multiple players in cancer development |
| Q37357126 | The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8 |
| Q27684624 | The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling. |
| Q35610627 | The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity |
| Q37402856 | The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. |
| Q35691527 | The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture |
| Q27930767 | The Rsp5 E3 ligase mediates turnover of low affinity phosphate transporters in Saccharomyces cerevisiae |
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