The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognition

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The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognition is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.048629
P932PMC publication ID2797283
P698PubMed publication ID19744925

P2093author name stringDavid J Katzmann
Andrea J Oestreich
Jacqueline R E Lee
Andrew P Norgan
Johanna A Payne
Mia S Gunawan
P2860cites workConformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligaseQ24292829
The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulationQ24306674
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndromeQ24563029
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteinsQ24645749
SWISS-MODEL: An automated protein homology-modeling serverQ24672647
The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargoQ24677536
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascadeQ27620360
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiaeQ27860636
Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteinsQ39935364
Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro.Q41851790
Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1.Q43240938
Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1.Q43704241
Determinants of ligand specificity in groups I and IV WW domains as studied by surface plasmon resonance and model building.Q43829875
The ubiquitin ligase Rsp5p is required for modification and sorting of membrane proteins into multivesicular bodiesQ47757717
NPl1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin-protein ligaseQ48070002
ConSeq: the identification of functionally and structurally important residues in protein sequencesQ48559824
Protein traffic in the yeast endocytic and vacuolar protein sorting pathwaysQ57179714
Ubiquitin Sorts Proteins into the Intralumenal Degradative Compartment of the Late-Endosome/VacuoleQ58480871
A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5pQ80825563
Mechanisms underlying ubiquitinationQ27860656
The ubiquitin systemQ27860803
A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus buddingQ27863679
Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5.Q27932680
Direct binding to Rsp5p regulates ubiquitination-independent vacuolar transport of Sna3p.Q27933875
Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodiesQ27934201
The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167.Q27936682
Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.Q27937366
Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway.Q27937377
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolasesQ27937990
Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targetingQ27938877
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.Q27939053
Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.Q27939068
Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.Q27939550
A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomesQ28245757
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domainQ28265018
N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein traffickingQ28271953
Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domainQ28281054
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular bodyQ29547922
Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosisQ29617390
Surprising similarities in structure comparisonQ29620326
Ubiquitin and ubiquitin-like proteins as multifunctional signalsQ30014838
Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodiesQ30159582
Rsp5 WW domains interact directly with the carboxyl-terminal domain of RNA polymerase II.Q30862970
Characterizing Class I WW domains defines key specificity determinants and generates mutant domains with novel specificitiesQ30986806
Rhabdoviruses and the cellular ubiquitin-proteasome system: a budding interactionQ31016943
Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteinsQ34368660
A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeastQ34671002
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architectureQ35691527
Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation.Q35803062
Targeting of Sna3p to the endosomal pathway depends on its interaction with Rsp5p and multivesicular body sorting on its ubiquitylationQ36320200
Regulation of DNA repair by ubiquitylationQ36457732
Ubiquitin and ubiquitin-like proteins in cancer pathogenesisQ36601000
Opposing activities of the Snx3-retromer complex and ESCRT proteins mediate regulated cargo sorting at a common endosomeQ36954183
P4510describes a project that usesImageQuantQ112270642
P433issue46
P407language of work or nameEnglishQ1860
P304page(s)32126-32137
P577publication date2009-09-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognition
P478volume284