Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies

scientific article

Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E06-06-0557
P932PMC publication ID1751313
P698PubMed publication ID17079730

P2093author name stringRobert C Piper
Younghoon Kee
Jihui Ren
Jon M Huibregtse
P2860cites workPossible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokinesQ22010172
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4Q24299260
The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulationQ24306674
Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific propertiesQ24532853
AMSH is an endosome-associated ubiquitin isopeptidaseQ24676880
The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargoQ24677536
Functional profiling of the Saccharomyces cerevisiae genomeQ27860544
Global analysis of protein expression in yeastQ27860658
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
A generic protein purification method for protein complex characterization and proteome explorationQ27861087
A comprehensive two-hybrid analysis to explore the yeast protein interactomeQ27861093
Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeastQ27930049
A combined experimental and computational strategy to define protein interaction networks for peptide recognition modulesQ27930492
The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membraneQ27931127
A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodiesQ27931399
Functional domains of the Rsp5 ubiquitin-protein ligase.Q27931992
Permease Recycling and Ubiquitination Status Reveal a Particular Role for Bro1 in the Multivesicular Body PathwayQ27933496
The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzymeQ27933628
Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiaeQ27933680
GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi networkQ27934125
Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permeaseQ27935024
Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.Q27935665
Zim17, a novel zinc finger protein essential for protein import into mitochondriaQ27935898
Transferrin receptor-like proteins control the degradation of a yeast metal transporterQ27935937
The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathwaysQ27936688
Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutantsQ27936883
Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosisQ27936947
The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting.Q27937143
Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.Q27937366
end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiaeQ27938116
Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.Q27938475
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.Q27939053
Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.Q27939068
The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions.Q27939323
Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applicationsQ28131600
Receptor downregulation and multivesicular-body sortingQ28131720
A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKPQ28138440
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomesQ28205230
A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomesQ28245757
Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomesQ28245945
WW domains of Rsp5p define different functions: determination of roles in fluid phase and uracil permease endocytosis in Saccharomyces cerevisiaeQ28345570
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14Q28359750
Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomesQ28511379
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular bodyQ29547922
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteinsQ29616733
A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeastQ29616852
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptorQ29618661
Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding ProteinsQ29619145
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like propertiesQ29620009
Structural basis for the binding of proline-rich peptides to SH3 domainsQ29620408
The biogenesis of multivesicular endosomesQ29620561
Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machineryQ30159944
A nonconserved Ala401 in the yeast Rsp5 ubiquitin ligase is involved in degradation of Gap1 permease and stress-induced abnormal proteinsQ33193077
Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathwayQ33559052
Ubiquitin-mediated targeting of a mutant plasma membrane ATPase, Pma1-7, to the endosomal/vacuolar system in yeastQ33693280
The GAT domains of clathrin-associated GGA proteins have two ubiquitin binding motifsQ34026517
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme familyQ34156341
Protein sorting into multivesicular endosomesQ34218897
Regulation of ubiquitin-binding proteins by monoubiquitinationQ34486954
Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation.Q35803062
The Hrs/STAM complex in the downregulation of receptor tyrosine kinasesQ36043224
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes.Q36117513
Ubiquitin and endocytic protein sortingQ36297842
Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeastQ36301450
Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome.Q36324529
Role of ubiquitylation in cellular membrane transportQ36443011
Antagonistic roles of ESCRT and Vps class C/HOPS complexes in the recycling of yeast membrane proteinsQ37497187
Regulation of epidermal growth factor receptor degradation by heterotrimeric Galphas proteinQ37657338
Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptorsQ42769697
Ligand-induced lysosomal epidermal growth factor receptor (EGFR) degradation is preceded by proteasome-dependent EGFR de-ubiquitinationQ42800213
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodiesQ42917525
c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic routeQ43700308
Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1.Q43704241
Expression of an enzymatically active parasite molecule in Escherichia coli: Schistosoma japonicum glutathione S-transferaseQ58039618
Ubiquitin Sorts Proteins into the Intralumenal Degradative Compartment of the Late-Endosome/VacuoleQ58480871
The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptorQ73316781
Ubiquitination of the PEST-like endocytosis signal of the yeast a-factor receptorQ73538505
The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiaeQ79209223
A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5pQ80825563
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmultivesicular bodyQ14878286
P304page(s)324-335
P577publication date2006-11-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleHse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies
P478volume18

Reverse relations

cites work (P2860)
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