UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation

scientific article

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1023552807
P356DOI10.1186/1741-7007-10-36
P932PMC publication ID3349548
P698PubMed publication ID22537386
P5875ResearchGate publication ID224853745

P50authorNicola T WoodQ57422668
Gabriela AlexandruQ57495288
P2093author name stringAxel Knebel
Susanne Bandau
Zoe O Gage
P2860cites workThe conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiaeQ24306410
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chainsQ24307429
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionQ24307473
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnoverQ24310742
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.Q24539071
XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexesQ24547630
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2Q24597101
Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradationQ24653719
The UBX domain: a widespread ubiquitin-like moduleQ27630532
Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulationQ27642010
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylationQ27649565
Proteasome subunit Rpn13 is a novel ubiquitin receptorQ27650664
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situQ27659474
A Dual E3 Mechanism for Rub1 Ligation to Cdc53Q27664416
Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymesQ27766356
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperoneQ27930650
Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome systemQ27935666
The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting.Q27937143
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastasesQ28139317
Identification of NEDD8-conjugation site in human cullin-2Q28139623
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated MacrophagesQ28143066
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycleQ28215051
Global phosphoproteome of HT-29 human colon adenocarcinoma cellsQ28266027
UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97Q28277816
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1Q28282227
Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor proteinQ28647626
Ubiquitin-binding domainsQ29614358
A 26 S protease subunit that binds ubiquitin conjugatesQ29614362
Ubiquitin-binding domainsQ29616461
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L.Q30950453
Nedd8 on cullin: building an expressway to protein destruction.Q33976667
Delivery of ubiquitinated substrates to protein-unfolding machinesQ33989072
The von Hippel-Lindau tumor suppressor proteinQ34132816
Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition.Q34412166
Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.Q34734854
Integration of oxygen signaling at the consensus HRE.Q36290265
The role of p97/Cdc48p in endoplasmic reticulum-associated degradation: from the immune system to yeast.Q36435571
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factorQ36562473
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugationQ37101488
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdownQ38583853
Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substratesQ39646650
Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stabilityQ40673171
Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivoQ40874935
Cdc48p(Npl4p/Ufd1p) binds and segregates membrane-anchored/tethered complexes via a polyubiquitin signal present on the anchorsQ42165110
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxiaQ42512319
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sortingQ44829594
Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerizationQ45345753
Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinasesQ45345757
Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex.Q46556619
Studies on the intracellular localization of hHR23B.Q52035626
P304page(s)36
P577publication date2012-04-26
P1433published inBMC BiologyQ2545642
P1476titleUBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation
P478volume10

Reverse relations

cites work (P2860)
Q64115469CUBAN, a Case Study of Selective Binding: Structural Details of the Discrimination between Ubiquitin and NEDD8
Q38736268CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis
Q36850952Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins
Q36764397Cardiac myocyte exosomes: stability, HSP60, and proteomics
Q36216079Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism
Q37547327Evolutionary conservation of primate lymphocryptovirus microRNA targets
Q35216145Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect
Q89475475Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein
Q35944520Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer
Q34621887Nedd8 processing enzymes in Schizosaccharomyces pombe
Q38970691Nucleotide Excision Repair: Finely Tuned Molecular Orchestra of Early Pre-incision Events
Q39398325Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition
Q34042816Protein neddylation: beyond cullin-RING ligases
Q90460701Proteomic and Transcriptomic Profiling Identifies Early Developmentally Regulated Proteins in Dictyostelium Discoideum
Q36455731Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system
Q26827548Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic
Q26747328Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin
Q28246908Should I stay or should I go: VCP/p97-mediated chromatin extraction in the DNA damage response
Q92651106Structure and Function of the AAA+ ATPase p97, a Key Player in Protein Homeostasis
Q24337489TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes
Q97519821The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Q37627642The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function
Q47210274The ubiquitin receptor DA1 interacts with the E3 ubiquitin ligase DA2 to regulate seed and organ size in Arabidopsis
Q28069036UBXD Proteins: A Family of Proteins with Diverse Functions in Cancer
Q38682988Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy
Q39149390Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism
Q33797100VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase
Q50296667VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7
Q50296665VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha
Q38719829p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex.
Q34303052p97 complexes as signal integration hubs.

Search more.