VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-8956103)

VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha is …
instance of (P31):
biological processQ2996394

External links are
P2888exact matchhttps://identifiers.org/reactome:R-HSA-8956103
P3937Reactome IDR-HSA-8956103

P2860cites workThe structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functionsQ26746044
UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulationQ34248457
Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complexQ35249854
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathwayQ35947206
DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligaseQ39196067
P703found in taxonHomo sapiensQ15978631
P527has part(s)hydroxyPro-HIF-alpha [cytosol]Q50252041
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]Q50269383
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]Q50269384
P361part ofNeddylationQ45317714

Reverse relations

part of (P361)
Q50269383RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]
Q50269384RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]
Q50252041hydroxyPro-HIF-alpha [cytosol]

Q45317714Neddylationhas part(s)P527

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