A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

scientific article

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ONC.2017.352
P932PMC publication ID5799715
P698PubMed publication ID28967904

P50authorAndrew J. BrooksQ55155147
Aaron G SmithQ55474040
Louise F NikolajsenQ57189221
Yash ChhabraQ58241725
Frederic A MeunierQ41876596
P2093author name stringH Y Wong
M J Waters
A Papadopulos
B B Kragelund
H Steinocher
K A Tunny
P2860cites workGrowth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humansQ24618226
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Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes.Q54532552
Tumor expression of human growth hormone and human prolactin predict a worse survival outcome in patients with mammary or endometrial carcinoma.Q54567241
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Deregulation of Stat5 expression and activation causes mammary tumors in transgenic miceQ80594368
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Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancerQ37602926
SOCS proteins in development and diseaseQ38124037
Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranesQ38890517
Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activationQ38964879
Correlation of Activated STAT3 Expression with Clinicopathologic Features in Lung Adenocarcinoma and Squamous Cell CarcinomaQ39669033
Oncogene-mediated inhibition of glycogen synthase kinase 3 beta impairs degradation of prolactin receptorQ40006280
The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptorQ40133210
Generation of mammalian cells stably expressing multiple genes at predetermined levels.Q40880769
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormoneQ41080169
Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activationQ41160052
Activated STAT3 correlates with prognosis of non-small cell lung cancer and indicates new anticancer strategiesQ41310543
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.Q42123048
Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signalingQ42449457
Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short statureQ42509194
Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2.Q42824711
Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatilityQ43121399
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life spanQ44559269
Increased site 1 affinity improves biopotency of porcine growth hormone. Evidence against diffusion dependent receptor dimerizationQ45009213
Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancerQ46197377
Lung cancer risk associated with Thr495Pro polymorphism of GHR in Chinese populationQ46734178
Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancerQ46831080
Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle dockingQ48222351
Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR DegradationQ27649020
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal OmegaQ27860809
Gigantism in mice lacking suppressor of cytokine signalling-2Q28140549
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)Q28201918
Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytesQ28209474
A versatile viral system for expression and depletion of proteins in mammalian cellsQ28475909
The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levelsQ28477287
Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptorQ28512825
Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterizationQ28575745
Plat-E: an efficient and stable system for transient packaging of retrovirusesQ29614830
Neuroendocrine control of pulsatile growth hormone release in the human: relationship with genderQ30306091
Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1-40). Evidence for intermittent somatostatin secretionQ30449397
Discovery of prognostic biomarkers for predicting lung cancer metastasis using microarray and survival dataQ30934284
ELM 2016--data update and new functionality of the eukaryotic linear motif resourceQ31029065
Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling schemeQ31114297
Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among WomenQ33817664
The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation.Q33855162
SOCS: physiological suppressors of cytokine signalingQ33980423
RefDB: a database of uniformly referenced protein chemical shiftsQ34185511
Inhibitors of cytokine signal transductionQ34275568
Regulation of cytokine signaling by SOCS family moleculesQ34279652
Mechanism of activation of protein kinase JAK2 by the growth hormone receptorQ34420222
The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growthQ34502673
Variants in the GH-IGF axis confer susceptibility to lung cancerQ34655360
A single arginine residue determines species specificity of the human growth hormone receptorQ34667715
Height, leg length, and cancer risk: a systematic reviewQ34794311
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancerQ35034550
Overlap extension PCR cloning: a simple and reliable way to create recombinant plasmidsQ35062969
Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway in non-small cell lung cancerQ35256618
Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis.Q35941268
Negative regulation of growth hormone receptor signaling.Q36203869
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout miceQ37153965
Regulatory mechanisms of growth hormone secretion are sexually dimorphicQ37387125
Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormoneQ37589848
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 InternationalQ42553662
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)489-501
P577publication date2017-10-02
P1433published inOncogeneQ1568657
P1476titleA growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation
P478volume37

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cites work (P2860)
Q91703988Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity
Q61797690Targeting growth hormone function: strategies and therapeutic applications
Q51766789The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects
Q94555032The effects of growth hormone on therapy resistance in cancer

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