KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8.

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KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. is …
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scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112.4340G
P356DOI10.1073/PNAS.1421441112
P932PMC publication ID4394310
P698PubMed publication ID25831548

P2093author name stringJing Yang
Jinzhi Wang
Jianghui Hou
Yongfeng Gong
Ronaldo Perez
Ernie Gonzales
P2860cites workKLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephronQ24307394
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertensionQ24321928
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4Q24338315
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudinsQ24633640
Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvementQ24672137
Human hypertension caused by mutations in WNK kinasesQ28212182
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunitsQ28249570
WNK kinases regulate thiazide-sensitive Na-Cl cotransportQ28584824
A SPAK isoform switch modulates renal salt transport and blood pressureQ28586855
Renal salt wasting and chronic dehydration in claudin-7-deficient miceQ33589127
Sodium and potassium balance depends on αENaC expression in connecting tubuleQ33718954
Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localizationQ34241219
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradationQ34442402
The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulationQ34583490
The role of molecular remodeling in differential regulation of tight junction permeabilityQ34617424
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3Q35140143
Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertensionQ35421933
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.Q35651892
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalitiesQ35754537
Claudin-16 and claudin-19 interact and form a cation-selective tight junction complexQ36330886
The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady stateQ36660697
Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidneyQ36719921
Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesiumQ37340830
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertensionQ37571326
The ubiquitin-proteasome pathway regulates claudin 5 degradationQ39385931
Syndrome of hypertension and hyperkalemia with normal glomerular filtration rateQ39499102
The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells.Q39871522
Na+ absorption defends from paracellular back-leakage by claudin-8 upregulationQ39919057
Study of claudin function by RNA interferenceQ40224183
Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 miceQ42478619
Expression of claudin-7 and -8 along the mouse nephron.Q44726960
Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome.Q45038689
Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.Q53051338
mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.Q53519195
Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor.Q53555787
Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption.Q54535930
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubuleQ80238253
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse modelQ80292340
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)4340-4345
P577publication date2015-03-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleKLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8.
P478volume112