| scholarly article | Q13442814 |
| P50 | author | David H. Ellison | Q37371230 |
| Joshua Curry | Q61827070 | ||
| P2093 | author name string | Kerim Mutig | |
| Sebastian Bachmann | |||
| James A McCormick | |||
| Ewout J Hoorn | |||
| Eric Delpire | |||
| Joshua H Nelson | |||
| Turgay Saritas | |||
| Chao-Ling Yang | |||
| Shaunessy Rogers | |||
| P2860 | cites work | 11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules. | Q38334578 |
| SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2. | Q40759182 | ||
| Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways | Q42757015 | ||
| Short-term stimulation of the thiazide-sensitive Na+-Cl- cotransporter by vasopressin involves phosphorylation and membrane translocation. | Q43223386 | ||
| Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density | Q44055170 | ||
| Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats | Q44303770 | ||
| ANG II provokes acute trafficking of distal tubule Na+-Cl(-) cotransporter to apical membrane | Q46774246 | ||
| Hypokalemia in a mouse model of Gitelman's syndrome | Q46910086 | ||
| Validation of volume-pressure recording tail-cuff blood pressure measurements | Q47304414 | ||
| An emerging role for SPAK in NCC, NKCC, and blood pressure regulation. | Q54645207 | ||
| Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule | Q77458583 | ||
| Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model | Q80292340 | ||
| Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter | Q24311551 | ||
| Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms | Q24537454 | ||
| Renal and brain isoforms of WNK3 have opposite effects on NCCT expression | Q24651730 | ||
| Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase | Q24654826 | ||
| WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells | Q24676697 | ||
| PASK (Proline-Alanine-rich STE20-related Kinase), a Regulatory Kinase of the Na-K-Cl Cotransporter (NKCC1) | Q28116210 | ||
| Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase | Q28210550 | ||
| Human hypertension caused by mutations in WNK kinases | Q28212182 | ||
| Angiotensin II induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter independent of aldosterone | Q28290886 | ||
| Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet | Q28564280 | ||
| Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform | Q28567514 | ||
| The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases | Q28583124 | ||
| Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1) | Q28593751 | ||
| Behavioral analysis of Ste20 kinase SPAK knockout mice | Q30475980 | ||
| Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia | Q33775321 | ||
| Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension | Q34241490 | ||
| SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction | Q34457030 | ||
| Adaptation of the distal convoluted tubule of the rat. Structural and functional effects of dietary salt intake and chronic diuretic infusion | Q34563840 | ||
| WNK1 kinase isoform switch regulates renal potassium excretion. | Q34694518 | ||
| Renal expression of parvalbumin is critical for NaCl handling and response to diuretics | Q35990289 | ||
| Role of the WNK-activated SPAK kinase in regulating blood pressure | Q36039159 | ||
| Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress | Q36117057 | ||
| Renal Na+-K+-Cl- cotransporter activity and vasopressin-induced trafficking are lipid raft-dependent. | Q36877776 | ||
| SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells | Q37037656 | ||
| Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles | Q37162333 | ||
| The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway | Q37289702 | ||
| Thiazide effects and adverse effects: insights from molecular genetics | Q37365882 | ||
| P433 | issue | 3 | |
| P921 | main subject | Serine/threonine kinase 39 | Q21984700 |
| P304 | page(s) | 352-364 | |
| P577 | publication date | 2011-09-01 | |
| P1433 | published in | Cell Metabolism | Q1254684 |
| P1476 | title | A SPAK isoform switch modulates renal salt transport and blood pressure | |
| P478 | volume | 14 |
| Q33792980 | A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters |
| Q36149053 | A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter |
| Q52684443 | AT2R (Angiotensin II Type 2 Receptor)-Mediated Regulation of NCC (Na-Cl Cotransporter) and Renal K Excretion Depends on the K Channel, Kir4.1. |
| Q35974133 | Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process |
| Q36106011 | Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action |
| Q37683426 | Annexin A2 mediates apical trafficking of renal Na⁺-K⁺-2Cl⁻ cotransporter |
| Q38866241 | Basolateral Kir4.1 activity in the distal convoluted tubule regulates K secretion by determining NaCl cotransporter activity |
| Q64979786 | Bradykinin Stimulates Renal Na+ and K+ Excretion by Inhibiting the K+ Channel (Kir4.1) in the Distal Convoluted Tubule. |
| Q89157356 | C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity |
| Q41372396 | CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension |
| Q36417867 | Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na⁺-K⁺-2Cl⁻ Cotransporter |
| Q48008398 | Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms |
| Q38241677 | Calcineurin inhibitors and hypertension: a role for pharmacogenetics? |
| Q36490322 | Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers |
| Q36223270 | Caveolin-1 Deficiency Inhibits the Basolateral K+ Channels in the Distal Convoluted Tubule and Impairs Renal K+ and Mg2+ Transport |
| Q30558974 | Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression |
| Q26827742 | Considerations when quantitating protein abundance by immunoblot |
| Q51035556 | Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules. |
| Q35882568 | Critical role of the SPAK protein kinase CCT domain in controlling blood pressure |
| Q47133778 | DNPEP is not the only peptidase that produces SPAK fragments in kidney. |
| Q48918213 | Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. |
| Q37476592 | Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition |
| Q52975643 | Distal convoluted tubule. |
| Q36654263 | Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties |
| Q36200312 | Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron |
| Q38189985 | Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation. |
| Q37619138 | Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin |
| Q54386214 | Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice. |
| Q35140143 | Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3 |
| Q58992876 | Hypertension: The Neglected Complication of Transplantation |
| Q35790509 | Hypertrophy in the Distal Convoluted Tubule of an 11β-Hydroxysteroid Dehydrogenase Type 2 Knockout Model |
| Q89936300 | Identification and characterization of alternative STK39 transcripts within human and mouse kidneys reveals species-specific regulation of blood pressure |
| Q33849100 | In silico analysis and experimental verification of OSR1 kinase - Peptide interaction |
| Q33568904 | Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis |
| Q42103841 | Integrated compensatory network is activated in the absence of NCC phosphorylation |
| Q36368224 | Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity |
| Q47678208 | K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl- cotransporter |
| Q34060743 | KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1). |
| Q35378646 | KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. |
| Q36598125 | Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target |
| Q90594938 | Kir4.1/Kir5.1 Activity Is Essential for Dietary Sodium Intake-Induced Modulation of Na-Cl Cotransporter |
| Q33660709 | Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systems |
| Q38618838 | Mini-review: regulation of the renal NaCl cotransporter by hormones |
| Q40779586 | Modulation of NCC activity by low and high K(+) intake: insights into the signaling pathways involved. |
| Q35900778 | Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport |
| Q47269007 | Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects |
| Q52717108 | Na+ -K+ -2Cl- Cotransporter (NKCC) Physiological Function in Nonpolarized Cells and Transporting Epithelia. |
| Q37972633 | Na+-K+-2Cl- cotransporter type 2 trafficking and activity: the role of interacting proteins |
| Q90669011 | Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule |
| Q37234799 | Novel diuretic targets |
| Q48108330 | Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK. |
| Q54481013 | OSR1-sensitive small intestinal Na+ transport. |
| Q60918261 | Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling |
| Q46786858 | Ovarian hormones and prolactin increase renal NaCl cotransporter phosphorylation. |
| Q46394327 | PGF2α regulates the basolateral K channels in the distal convoluted tubule |
| Q33723923 | Pathogenesis of calcineurin inhibitor-induced hypertension |
| Q93361499 | Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney |
| Q33855431 | PharmGKB summary: Diuretics pathway, pharmacodynamics |
| Q39415845 | Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. |
| Q39999682 | Phosphorylation decreases ubiquitylation of the thiazide-sensitive cotransporter NCC and subsequent clathrin-mediated endocytosis. |
| Q38813066 | Physiological role of SLC12 family members in the kidney. |
| Q37424563 | Physiology and pathophysiology of SLC12A1/2 transporters |
| Q38245896 | Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2). |
| Q26864902 | Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts |
| Q49680643 | Plasma Potassium Determines NCC Abundance in Adult Kidney-Specific γENaC Knockout. |
| Q48000331 | Potassium Sensing by Renal Distal Tubules Requires Kir4.1. |
| Q50135006 | Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel. |
| Q35095908 | Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride |
| Q47296379 | Potassium-Regulated Distal Tubule WNK Bodies are Kidney-Specific WNK1 Dependent |
| Q37604706 | Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension |
| Q86215259 | Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice |
| Q54400095 | Regulation of NKCC2 activity by SPAK truncated isoforms. |
| Q28593760 | Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2 |
| Q39347476 | Regulation of renal Na-(K)-Cl cotransporters by vasopressin. |
| Q36494423 | Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation |
| Q57289570 | Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway |
| Q36849244 | Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension. |
| Q52708936 | Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice. |
| Q63342498 | Renal sodium and magnesium reabsorption are not coupled in a mouse model of Gordon syndrome |
| Q39227671 | Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure |
| Q39859076 | SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule. |
| Q34988698 | SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation |
| Q36638355 | SPAK differentially mediates vasopressin effects on sodium cotransporters. |
| Q36368185 | SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner. |
| Q35436934 | SPAK-mediated NCC regulation in response to low-K+ diet |
| Q35138491 | STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb |
| Q38752148 | Severe hyperkalemia is rescued by low-potassium diet in renal βENaC-deficient mice. |
| Q34355791 | Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage |
| Q33770703 | Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension. |
| Q92459181 | Tacrolimus-induced hypomagnesemia and hypercalciuria requires FKBP12 suggesting a role for calcineurin |
| Q37072434 | The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy |
| Q42392429 | The Ste20 kinases SPAK and OSR1 travel between cells through exosomes |
| Q36802752 | The absence of intrarenal ACE protects against hypertension |
| Q37139466 | The expression, regulation, and function of Kir4.1 (Kcnj10) in the mammalian kidney |
| Q38169097 | The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation |
| Q39698346 | Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis |
| Q38971764 | Unsung renal receptors: orphan G-protein-coupled receptors play essential roles in renal development and homeostasis |
| Q36176627 | Vasopressin-induced stimulation of the Na(+)-activated K(+) channels is responsible for maintaining the basolateral K(+) conductance of the thick ascending limb (TAL) in EAST/SeSAME syndrome |
| Q37992360 | WNK kinases and the kidney |
| Q37694287 | WNK signalling pathways in blood pressure regulation |
| Q48037671 | WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. |
| Q50141002 | With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo. |
| Q50141007 | α-ketoglutarate stimulates pendrin-dependent Cl- absorption in the mouse CCD through protein kinase C. |
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