| scholarly article | Q13442814 |
| P2093 | author name string | Mark Hannink | |
| Shih-Ching Lo | |||
| P2860 | cites work | Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer | Q23923854 |
| Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2 | Q24170511 | ||
| Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling | Q24298930 | ||
| DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2 | Q24305442 | ||
| A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells | Q24307672 | ||
| The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking | Q24319150 | ||
| Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis | Q24336670 | ||
| Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein | Q24534146 | ||
| Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex | Q24559743 | ||
| Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis | Q24562044 | ||
| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 | Q24563807 | ||
| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain | Q24609907 | ||
| The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer | Q24685712 | ||
| Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination | Q27645983 | ||
| A Phosphatase Activity of Sts-1 Contributes to the Suppression of TCR Signaling | Q27646954 | ||
| Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response | Q27647812 | ||
| Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3 | Q27861127 | ||
| Function and regulation of cullin-RING ubiquitin ligases | Q28131707 | ||
| Oxidants, oxidative stress and the biology of ageing | Q28131725 | ||
| Structure, function, and evolution of phosphoglycerate mutases: comparison with fructose-2,6-bisphosphatase, acid phosphatase, and alkaline phosphatase | Q28144542 | ||
| Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene | Q28204923 | ||
| A human homologue of Drosophila kelch associates with myosin-VIIa in specialized adhesion junctions | Q28211256 | ||
| The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm | Q28216217 | ||
| Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants | Q28218883 | ||
| Mitochondria: dynamic organelles in disease, aging, and development | Q28249783 | ||
| Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein | Q28283167 | ||
| Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2 | Q28382872 | ||
| Keap1 in adhesion complexes | Q28571737 | ||
| Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1 | Q28583647 | ||
| Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2 | Q28587191 | ||
| Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes | Q28593237 | ||
| Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model | Q28910182 | ||
| Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway | Q29547371 | ||
| Mitochondrial formation of reactive oxygen species | Q29547906 | ||
| Translocation of proteins into mitochondria | Q29616478 | ||
| Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer | Q29616499 | ||
| The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase | Q29616502 | ||
| Regulatory mechanisms controlling gene expression mediated by the antioxidant response element | Q29616504 | ||
| Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription | Q29617066 | ||
| Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress | Q29617845 | ||
| Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation | Q29618051 | ||
| Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases | Q30164059 | ||
| Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. | Q30440422 | ||
| In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries | Q31889951 | ||
| Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription | Q33551416 | ||
| Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism | Q33836992 | ||
| Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2 | Q33900511 | ||
| Oxidative stress and cancer: have we moved forward? | Q34001313 | ||
| Mitochondrial failures in Alzheimer's disease | Q36000745 | ||
| Specificity in reactive oxidant signaling: think globally, act locally | Q36118494 | ||
| Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling | Q36364677 | ||
| Expanding insights of mitochondrial dysfunction in Parkinson's disease. | Q36404133 | ||
| Oxidative stress: a bridge between Down's syndrome and Alzheimer's disease | Q36453571 | ||
| Interaction of the smooth endoplasmic reticulum and mitochondria | Q36482062 | ||
| Mitochondrial mutations in cancer | Q36557971 | ||
| An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations | Q36569112 | ||
| Disruption of mitochondrial redox circuitry in oxidative stress | Q36592812 | ||
| Redefining oxidative stress | Q36598878 | ||
| The rotenone model of parkinsonism--the five years inspection. | Q36611533 | ||
| Controversies on new animal models of Parkinson's disease pro and con: the rotenone model of Parkinson's disease (PD). | Q36611535 | ||
| Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. | Q38327788 | ||
| Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice | Q38340562 | ||
| An unsuspected ecdysteroid/steroid phosphatase activity in the key T-cell regulator, Sts-1: surprising relationship to insect ecdysteroid phosphate phosphatase | Q40161441 | ||
| Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells--evidence for cullin dimerization | Q40178983 | ||
| Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. | Q40204136 | ||
| PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex | Q40219081 | ||
| Caveolin-1 and lipid rafts in confluent BeWo trophoblasts: evidence for Rock-1 association with caveolin-1. | Q40316026 | ||
| CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. | Q40322697 | ||
| High susceptibility of a human oligodendroglial cell line to herpes simplex type 1 infection. | Q40394822 | ||
| Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation | Q40403963 | ||
| Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress | Q40496111 | ||
| Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes. | Q40890652 | ||
| MITOPRED: a web server for the prediction of mitochondrial proteins | Q41010609 | ||
| Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins | Q41092707 | ||
| Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion | Q42501152 | ||
| Nrf2-deficient female mice develop lupus-like autoimmune nephritis | Q43750335 | ||
| Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane | Q46854767 | ||
| Subcellular localization and cytoplasmic complex status of endogenous Keap1. | Q46976303 | ||
| Fbw7 isoform interaction contributes to cyclin E proteolysis. | Q53581033 | ||
| Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex. | Q53616483 | ||
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| mitochondrion | Q39572 | ||
| P304 | page(s) | 1789-803 | |
| P577 | publication date | 2008-05-01 | |
| P1433 | published in | Experimental Cell Research | Q1524289 |
| P1476 | title | PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria | |
| P478 | volume | 314 |
| Q38873549 | 6-OHDA-Induced Changes in Parkinson's Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells |
| Q38609453 | A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking. |
| Q34139093 | A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5. |
| Q35988956 | Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis |
| Q24704009 | Advances in mechanisms of anti-oxidation |
| Q52586912 | Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2. |
| Q38084832 | Atypical protein phosphatases: emerging players in cellular signaling |
| Q42433891 | Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis |
| Q36557495 | Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution |
| Q30534481 | Computational classification of mitochondrial shapes reflects stress and redox state |
| Q28393784 | Cytoprotection "gone astray": Nrf2 and its role in cancer |
| Q51318673 | Early Stage Functions of Mitochondrial Autophagy and Oxidative Stress in Acetaminophen-Induced Liver Injury. |
| Q37133517 | Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease |
| Q47899237 | Effects of Glucagon-Like Peptide-1 on Oxidative Stress and Nrf2 Signaling |
| Q36395493 | Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model |
| Q39029699 | Effects of ionizing radiation on the heart |
| Q37199592 | Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes |
| Q30663205 | Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response. |
| Q26830515 | Fueling the flames: Mammalian programmed necrosis in inflammatory diseases |
| Q35859412 | Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. |
| Q61805398 | Functional role of PGAM5 multimeric assemblies and their polymerization into filaments |
| Q47230657 | Gene expression analysis in peripheral blood cells of patients with hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC): identification of NRF2 pathway activation. |
| Q35688037 | Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder |
| Q58700394 | High PGAM5 expression induces chemoresistance by enhancing Bcl-xL-mediated anti-apoptotic signaling and predicts poor prognosis in hepatocellular carcinoma patients |
| Q48282541 | Impact of cigarette-smoking on sperm DNA methylation and its effect on sperm parameters |
| Q28474531 | Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia |
| Q37101549 | Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species |
| Q28395156 | Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis |
| Q46268778 | Ischemic Preconditioning Protects Astrocytes against Oxygen Glucose Deprivation Via the Nuclear Erythroid 2-Related Factor 2 Pathway. |
| Q28394732 | Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease |
| Q37354043 | Microparticulate/Nanoparticulate Powders of a Novel Nrf2 Activator and an Aerosol Performance Enhancer for Pulmonary Delivery Targeting the Lung Nrf2/Keap-1 Pathway |
| Q28552780 | Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis |
| Q93113555 | Mitochondrial biology in airway pathogenesis and the role of NRF2 |
| Q95323313 | Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics |
| Q40463091 | Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury. |
| Q24312673 | Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1 |
| Q38200391 | Monitoring Keap1-Nrf2 interactions in single live cells |
| Q26747249 | NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer |
| Q47350229 | Nrf2 at the Heart of Oxidative Stress and Cardiac Protection |
| Q38315482 | Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium |
| Q28396758 | Nrf2 protects mitochondrial decay by oxidative stress |
| Q28394597 | Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis |
| Q34651070 | Nuclear cytoplasmic trafficking of proteins is a major response of human fibroblasts to oxidative stress |
| Q46237055 | Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway |
| Q59360270 | Oxeiptosis-a cell death pathway to mitigate damage caused by radicals |
| Q38596849 | Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration |
| Q41671818 | PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila. |
| Q50036991 | Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling |
| Q39717064 | Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway |
| Q34162494 | Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster |
| Q39352782 | Proteasome Structure and Assembly |
| Q28390091 | Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging |
| Q90009190 | Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy |
| Q40909612 | Protein composition of immunoprecipitated synaptic ribbons |
| Q38319396 | Proteomics reveals the importance of the dynamic redistribution of the subcellular location of proteins in breast cancer cells |
| Q26782529 | Reactive oxygen species and mitochondria: A nexus of cellular homeostasis |
| Q28394996 | Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism |
| Q26849213 | Redox regulation of mitochondrial biogenesis |
| Q42293431 | Redox-Related Epigenetic Mechanisms in Glioblastoma: Nuclear Factor (Erythroid-Derived 2)-Like 2, Cobalamin, and Dopamine Receptor Subtype 4 |
| Q89805787 | Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology |
| Q28392708 | Regulation of proteasome activity in health and disease |
| Q37906733 | Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications |
| Q90441343 | Resveratrol protects against oxidative stress by activating the Keap-1/Nrf2 antioxidant defense system in obese-asthmatic rats |
| Q42051309 | Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5 |
| Q23919669 | Role of Nrf2 in oxidative stress and toxicity |
| Q36733239 | SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans |
| Q36487099 | Spatial and temporal dynamics of the cardiac mitochondrial proteome |
| Q28384783 | Stress-activated cap'n'collar transcription factors in aging and human disease |
| Q40961063 | Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly |
| Q36569330 | Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator |
| Q88646850 | Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target |
| Q64973480 | Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration. |
| Q36754187 | The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress |
| Q34344659 | The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy |
| Q50042104 | The Crosstalk between Nrf2 and Inflammasomes |
| Q36386948 | The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. |
| Q43372995 | The Role of Nrf2 in Cardiovascular Function and Disease |
| Q64069200 | The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis |
| Q27324113 | The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans |
| Q37848718 | The cytoprotective role of the Keap1-Nrf2 pathway |
| Q28388959 | The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function |
| Q33769553 | The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila |
| Q45161551 | The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. |
| Q24302411 | The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways |
| Q90117396 | The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1 |
| Q59925072 | The multifaceted role of Nrf2 in mitochondrial function |
| Q21285141 | The phosphorylation-dependent regulation of mitochondrial proteins in stress responses |
| Q47624817 | The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer |
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| Q34960760 | The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2. |
| Q42514932 | Transcriptional Regulation by Nrf2. |
| Q37977719 | Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes |
| Q46278760 | Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses |
| Q30038970 | Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development |
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