Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis

scientific article

Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

External links are
P356DOI10.1074/JBC.M111.275073
P3181OpenCitations bibliographic resource ID1379258
P932PMC publication ID3247995
P698PubMed publication ID22072718

P2093author name stringSuryakant K Niture
Anil K Jaiswal
P2860cites workAccelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null miceQ23923904
The Hallmarks of CancerQ221226
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell deathQ24312157
Enrolling women into HIV preventive vaccine trials: an ethical imperative but a logistical challengeQ25255907
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell deathQ27733156
Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting functionQ28239381
Cell death: critical control pointsQ28240722
Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated proteinQ28283167
An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophenQ28361995
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondriaQ28384526
Nrf2 signaling and cell survivalQ28394210
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancerQ28469051
Bcl-XL and Bcl-2 repress a common pathway of cell deathQ28505812
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient miceQ29615438
Nrf2:INrf2 (Keap1) signaling in oxidative stressQ29615712
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancerQ29616499
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activationQ29618051
Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisonsQ30658935
In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display librariesQ31889951
An autoregulatory loop between Nrf2 and Cul3-Rbx1 controls their cellular abundanceQ33967398
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesisQ33981477
INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosisQ34441957
Bad-deficient mice develop diffuse large B cell lymphomaQ35234507
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in miceQ36402881
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbetaQ37406535
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survivalQ38359163
Prothymosin-alpha mediates nuclear import of the INrf2/Cul3 Rbx1 complex to degrade nuclear Nrf2.Q39874226
An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance.Q40070103
PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complexQ40219081
Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallateQ40236612
Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.Q40890652
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaustQ43662015
Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysemaQ47680966
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)44542-56
P577publication date2011-12-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleInhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis
P478volume286

Reverse relations

cites work (P2860)
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