Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator

scientific article published on 29 November 2012

Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2012.10.022
P932PMC publication ID3557559
P698PubMed publication ID23201124
P5875ResearchGate publication ID233827432

P50authorAlma L BurlingameQ78114859
P2093author name stringMin Zhuang
James A Wells
Haopeng Wang
Shenheng Guan
P2860cites workA serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell deathQ24291746
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathwaysQ24302411
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1Q24312673
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligaseQ24337721
Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPsQ24544173
Functional analysis of the human CDC5L complex and identification of its components by mass spectrometryQ24596551
Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acidQ24604552
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell deathQ24630370
Systematic and quantitative assessment of the ubiquitin-modified proteomeQ24634631
Global mapping of the topography and magnitude of proteolytic events in apoptosisQ24649031
Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N terminiQ24653446
Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin LigasesQ27657740
N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein ComplexQ27674398
WebLogo: A Sequence Logo GeneratorQ27860646
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLOQ28201640
Characterization of the FKBP.rapamycin.FRB ternary complexQ28242140
A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)Q28296386
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondriaQ28384526
Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeastQ33286808
Small-molecule activators of a proenzymeQ33515227
Characterization of XIAP-deficient miceQ33559119
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in DrosophilaQ33769553
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundanceQ34132152
The N-end rule pathway of protein degradationQ34422495
Novel substrates and functions for the ubiquitin-like molecule NEDD8.Q34827554
Identification of SCF ubiquitin ligase substrates by global protein stability profilingQ34874145
Global kinetic analysis of proteolysis via quantitative targeted proteomicsQ35751043
IAPs, RINGs and ubiquitylationQ36085601
Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosisQ36140643
Regulation of apoptosis by XIAP ubiquitin-ligase activityQ36843515
The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in DrosophilaQ37195472
Control of cullin-ring ubiquitin ligase activity by nedd8.Q37827465
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and deathQ37893455
Targeting IAP proteins for therapeutic intervention in cancerQ37980321
Global identification of modular cullin-RING ligase substratesQ39462405
Activation of specific apoptotic caspases with an engineered small-molecule-activated proteaseQ39665585
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspasesQ42657216
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processingQ43136832
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitroQ44066914
A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linkingQ46181926
A proteomic screen reveals the mitochondrial outer membrane protein Mdm34p as an essential target of the F-box protein Mdm30p.Q47360850
Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifsQ57369787
A conserved tetrapeptide motif: potentiating apoptosis through IAP-bindingQ77628110
P433issue2
P304page(s)273-282
P577publication date2012-11-29
P1433published inMolecular CellQ3319468
P1476titleSubstrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator
P478volume49

Reverse relations

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