The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

scientific article published on January 2014

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2014NatCo...5.3291M
P356DOI10.1038/NCOMMS4291
P932PMC publication ID3929782
P698PubMed publication ID24518117
P5875ResearchGate publication ID260148670

P50authorFrancesca MattiroliQ57514790
Michael UckelmannQ84525690
Titia SixmaQ21402771
P2093author name stringWillem J van Dijk
Danny D Sahtoe
P2860cites workHistone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors.Q53276828
Characterization of nucleosome core particles containing histone proteins made in bacteriaQ73770026
New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioningQ74352513
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomesQ24292928
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2Q24294888
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complexQ24296990
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signalingQ24298746
Role of histone H2A ubiquitination in Polycomb silencingQ24305090
UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathwayQ24305173
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligaseQ24306203
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damageQ24309181
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsQ24309287
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexQ24315785
RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AXQ24317544
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1bQ24337331
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaksQ24339324
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitroQ24608829
Structural basis for autoinhibition and phosphorylation-dependent activation of c-CblQ24621898
Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylationQ24633548
Control of cell growth by the SCF and APC/C ubiquitin ligasesQ24647543
Origin and function of ubiquitin-like proteinsQ24651141
Crystal structure of a nucleosome core particle containing the variant histone H2A.ZQ27628748
Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolutionQ27639217
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysisQ27670947
BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimerQ27671574
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activationQ27675805
RING domain E3 ubiquitin ligasesQ27860546
A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.Q27934010
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS.Q27939071
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencingQ28287373
How proteolysis drives the cell cycleQ28297983
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin markQ29465773
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeastQ29617217
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesisQ29619757
Culprits in the degradation of cyclin E apprehendedQ33771904
Expression and purification of recombinant histones and nucleosome reconstitutionQ33914576
A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structureQ34270749
Reconstitution of nucleosome core particles from recombinant histones and DNA.Q34296889
The nucleosome surface regulates chromatin compaction and couples it with transcriptional repressionQ34707393
ATP-dependent chromatin remodeling in the DNA-damage response.Q35744850
Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.Q36291328
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylationQ37175650
Beyond ATM: the protein kinase landscape of the DNA damage responseQ37875377
RINGs hold the key to ubiquitin transferQ37966409
The chromatin response to DNA breaks: leaving a mark on genome integrityQ38081947
The role of the nucleosome acidic patch in modulating higher order chromatin structureQ38085143
Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identityQ38323091
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradationQ39540070
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.Q40318272
A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligaseQ42249588
Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitinQ42573161
Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5.Q42600350
Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2pQ46576875
Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.Q46711534
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P2507corrigendum / erratumErratum: The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.Q49257514
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)3291
P577publication date2014-01-01
P1433published inNature CommunicationsQ573880
P1476titleThe nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A
P478volume5

Reverse relations

cites work (P2860)
Q54216760A Screen for Epstein-Barr Virus Proteins that Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein.
Q48411490An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168.
Q33843055An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells
Q42221274Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.
Q38806099BAP1/ASXL1 recruitment and activation for H2A deubiquitination.
Q27701535BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase
Q43212891BRCA1 is a histone-H2A-specific ubiquitin ligase
Q37249161Capturing a substrate in an activated RING E3/E2-SUMO complex
Q63409524Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity
Q49829381Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes
Q90707564Chromatin regulation and dynamics in stem cells
Q37441289Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients
Q42001356Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome
Q47834702Endothelial-specific m(6)A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling.
Q92105561Enzymatic Logic of Ubiquitin Chain Assembly
Q49257514Erratum: The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.
Q95324882Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination
Q35156905Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation
Q35941469Interplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19(ARF)/p53 axis in hematopoiesis, early T-cell development and tissue differentiation
Q38201971Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.
Q51000552Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18.
Q41640286Monoubiquitination of histone H2B is intrinsic to the Bre1 RING domain-Rad6 interaction and augmented by a second Rad6-binding site on Bre1
Q86246092Nucleosome structure and function
Q38655184Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks
Q50494189Reading chromatin signatures after DNA double-strand breaks.
Q26752453Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks
Q36805622Recognition of the nucleosome by chromatin factors and enzymes
Q38841261Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers.
Q48042582Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α.
Q42374197Spatially restricted loading of BRD2 at DNA double-strand breaks protects H4 acetylation domains and promotes DNA repair
Q38656328Spatiotemporal regulation of posttranslational modifications in the DNA damage response
Q90180949Strategy for Development of Site-Specific Ubiquitin Antibodies
Q64114367Structural basis of specific H2A K13/K15 ubiquitination by RNF168
Q48251425Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168.
Q37095471Structure Change from β-Strand and Turn to α-Helix in Histone H2A-H2B Induced by DNA Damage Response
Q24299638Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8
Q35737433The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in Saccharomyces cerevisiae
Q92937229The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo
Q38848092The nucleosome: orchestrating DNA damage signaling and repair within chromatin.
Q27722410The structural basis of modified nucleosome recognition by 53BP1
Q52532574The tale of a tail: histone H4 acetylation and the repair of DNA breaks.
Q50280774Total Chemical Synthesis of Modified Histones
Q38494694Touch, act and go: landing and operating on nucleosomes
Q36410188Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners
Q28087342Ubiquitylation, neddylation and the DNA damage response
Q26742134Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair

Q49257514Erratum: The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.main subjectP921