Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

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Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1003183
P932PMC publication ID3585151
P698PubMed publication ID23468625
P5875ResearchGate publication ID235882684

P50authorGeoffrey Lilley SmithQ5069186
Carlos Maluquer de MotesQ42150779
P2093author name stringAndrew G Bowie
Daniel S Mansur
Hongwei Ren
Leonie Unterholzner
Rebecca P Sumner
Brian J Ferguson
Pavla Strnadova
P2860cites workRotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonismQ21090517
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexesQ24299311
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphaseQ24304123
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic proteinQ24305049
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligaseQ24306203
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14Q24312867
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activationQ24315019
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7Q24338222
Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than ApoptosisQ27651621
Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to VirulenceQ27676390
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.Q28118570
Approaching the asymptote: 20 years laterQ28249107
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motifQ28276184
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathwayQ28615591
Steroid hormone synthesis by a vaccinia enzyme: a new type of virus virulence factor.Q54381288
Vaccinia virus immune evasionQ73992874
The vaccinia virus N1L protein is an intracellular homodimer that promotes virulenceQ40717481
The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B.Q40816820
Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.Q41763836
Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virusQ42600414
Vaccinia virus gene A36R encodes a M(r) 43-50 K protein on the surface of extracellular enveloped virusQ42601218
Deletion of 55 open reading frames from the termini of vaccinia virusQ42626327
Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligaseQ42631679
Structure of vaccinia virus late promotersQ43610128
A model for vaccinia virus pathogenesis and immunity based on intradermal injection of mouse ear pinnaeQ43646853
Biological characterization of recombinant vaccinia viruses in mice infected by the respiratory routeQ45110748
Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routesQ45731710
Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway.Q45749099
Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificityQ45785576
A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infectionQ45872018
HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-cateninQ47965199
Shared principles in NF-kappaB signalingQ29547234
SCF and Cullin/Ring H2-based ubiquitin ligasesQ29547637
Multiple sequence alignment with Clustal XQ29547758
Genome sequence diversity and clues to the evolution of variola (smallpox) virusQ30230463
Repulsion of superinfecting virions: a mechanism for rapid virus spreadQ30594313
Vaccinia virus protein C16 acts intracellularly to modulate the host response and promote virulenceQ33910501
IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNAQ34029053
The nuclear factor NF-kappaB pathway in inflammationQ34114512
Poxviruses and immune evasionQ34172411
Poxvirus genomes: a phylogenetic analysisQ34289377
A vaccinia virus deletion mutant reveals the presence of additional inhibitors of NF-kappaB.Q34485252
Mutations in modified virus Ankara protein 183 render it a non-functional counterpart of B14, an inhibitor of nuclear factor kappaB activation.Q34641590
Regulation of adaptive immunity by the innate immune systemQ34659642
Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells.Q35024097
A versatile ligation-independent cloning method suitable for high-throughput expression screening applicationsQ35804580
Vaccinia DNA ligase complements Saccharomyces cerevisiae cdc9, localizes in cytoplasmic factories and affects virulence and virus sensitivity to DNA damaging agentsQ35938171
Steroid hormone synthesis by vaccinia virus suppresses the inflammatory response to infectionQ36370370
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defenseQ36370571
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulenceQ36403362
Vaccinia virus interleukin-18-binding protein promotes virulence by reducing gamma interferon production and natural killer and T-cell activityQ36464830
Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence.Q36523222
Transient dominant selection of recombinant vaccinia viruses.Q36808769
Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genesQ36890933
The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradationQ37010771
Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathwaysQ37232811
A mechanism for the inhibition of fever by a virusQ37307863
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.Q37421291
Targeting of immune signalling networks by bacterial pathogensQ37464760
The NF-kappaB family of transcription factors and its regulationQ37672294
How vaccinia virus has evolved to subvert the host immune response.Q37855047
Regulation of NF-κB by ubiquitination and degradation of the IκBsQ37995680
β-TrCP dependency of HIV-1 Vpu-induced downregulation of CD4 and BST-2/tetherin.Q38004561
Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3.Q39697230
Vaccinia virus strain Western Reserve protein B14 is an intracellular virulence factorQ40280952
Vaccinia virus encodes a thymidylate kinase gene: sequence and transcriptional mappingQ40537769
Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptorsQ40542008
Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation.Q40629419
The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal modelQ40695890
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue2
P921main subjectNF-κBQ411114
evasion of host immune responseQ1660157
P304page(s)e1003183
P577publication date2013-02-28
P1433published inPLOS PathogensQ283209
P1476titlePoxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence
P478volume9

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