Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis

scientific article published on 8 August 2017

Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/V9080215
P932PMC publication ID5580472
P698PubMed publication ID28786952

P50authorDaniel Brian NicholsQ96101929
Jessica CottrellQ122878340
William De MartiniQ122878363
P2860cites workThe N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complexQ83115967
A new inhibitor of apoptosis from vaccinia virus and eukaryotesQ21131614
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaQ22011091
Vaccinia virus CrmE encodes a soluble and cell surface tumor necrosis factor receptor that contributes to virus virulenceQ24292403
The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entryQ24299966
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutationsQ24302236
Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosisQ24302248
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic proteinQ24305049
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoformsQ24311676
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexesQ24312187
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cellsQ24312865
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
Inhibition of death receptor signals by cellular FLIPQ24316446
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionQ24318426
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family proteinQ24319056
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligandsQ24321449
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell deathQ24336389
Structure of CrmE, a virus-encoded tumour necrosis factor receptorQ24336789
TRAF family proteins link PKR with NF-kappa B activationQ24338458
Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1beta-converting enzyme in vitro and unlike CrmA cannot block apoptosis in cowpox virus-infected cellsQ24527273
Identification of novel stress-induced genes downstream of chopQ24533261
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosisQ24554008
The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinaseQ24561643
Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutatedQ24609947
A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminaseQ24654692
Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathwayQ24671908
A role for Z-DNA binding in vaccinia virus pathogenesisQ24680885
An overview of the serpin superfamilyQ24684030
Cloak and Dagger: Alternative Immune Evasion and Modulation Strategies of PoxvirusesQ26797325
The evolution of poxvirus vaccinesQ26995905
Human MonkeypoxQ27023061
X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognitionQ27639516
Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2Q27644227
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and BakQ27644243
Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than ApoptosisQ27651621
Mechanism of procaspase-8 activation by c-FLIPLQ27655368
Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to VirulenceQ27676390
Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1LQ27683883
Structural basis of Deerpox virus-mediated inhibition of apoptosisQ27701743
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA virusesQ27860455
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse modelQ33835582
Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasionQ33843114
The vaccinia virus superoxide dismutase-like protein (A45R) is a virion component that is nonessential for virus replication.Q33844429
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.Q33941041
Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibitionQ34012966
The molecular architecture of the TNF superfamilyQ34109796
Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesisQ34236342
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzymeQ34240507
Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorderQ34264277
The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formationQ34301763
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activationQ34311133
Multiple functions of BCL-2 family proteinsQ34326024
Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic functionQ34357751
Molluscum contagiosum virus infection.Q34366261
When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA.Q34380769
Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migrationQ34464360
Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpinsQ34515383
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein ResponseQ34547514
A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virusQ34596242
Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulenceQ34611139
Caspase-12 and ER-stress-mediated apoptosis: the story so far.Q34649447
Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.Q34709600
Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax.Q34741839
Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replicationQ34819569
Orchestrating the unfolded protein response in health and diseaseQ35001604
Role of SODD in Regulation of Tumor Necrosis Factor ResponsesQ35002349
MAVS-MKK7-JNK2 defines a novel apoptotic signaling pathway during viral infectionQ35126547
Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.Q35131723
Poxvirus decapping enzymes enhance virulence by preventing the accumulation of dsRNA and the induction of innate antiviral responsesQ35177770
Vaccinia virus transcriptionQ35199087
Outbreak of severe zoonotic vaccinia virus infection, Southeastern BrazilQ35229732
Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane ruptureQ35236032
Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim.Q35274610
Comparative analysis of poxvirus orthologues of the vaccinia virus E3 protein: modulation of protein kinase R activity, cytokine responses, and virus pathogenicityQ35531431
A method for the generation of ectromelia virus (ECTV) recombinants: in vivo analysis of ECTV vCD30 deletion mutantsQ33429965
Membrane rupture generates single open membrane sheets during vaccinia virus assemblyQ33484010
A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cellsQ33565441
Vaccinia virus protein F1L is a caspase-9 inhibitorQ33648434
Apoptosis signaling in lymphocytes.Q33664747
Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosisQ33717065
Tumorigenic poxviruses up-regulate intracellular superoxide to inhibit apoptosis and promote cell proliferationQ33755152
Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domainQ33781751
Caspase inhibitors.Q33782509
Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus.Q33784673
The IRF-3 transcription factor mediates Sendai virus-induced apoptosisQ33802650
On the biosynthesis and structure of double-stranded RNA in vaccinia virus-infected cellsQ33819029
CrmE, a novel soluble tumor necrosis factor receptor encoded by poxviruses.Q33834737
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphatesQ27861007
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Q27861127
Regulation of translation initiation in eukaryotes: mechanisms and biological targetsQ28111696
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cellsQ28119154
5'-Triphosphate RNA is the ligand for RIG-IQ28131726
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
Viral mimicry of cytokines, chemokines and their receptorsQ28201716
The TNF and TNF receptor superfamilies: integrating mammalian biologyQ28203717
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient miceQ28235461
Death receptors: signaling and modulationQ28280897
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complexQ28283294
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitinationQ28284721
Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calciumQ28287491
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
Role of Bax and Bak in mitochondrial morphogenesisQ28591724
TAM receptors are pleiotropic inhibitors of the innate immune responseQ28592484
A unified model for apical caspase activationQ28609101
Target protease specificity of the viral serpin CrmA. Analysis of five caspasesQ28640190
Assembly of vaccinia virus: role of the intermediate compartment between the endoplasmic reticulum and the Golgi stacksQ29039026
The Complete DNA Sequence of Myxoma VirusQ29394705
Caspases: enemies withinQ29547315
The mammalian unfolded protein responseQ29547400
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFQ29615685
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membraneQ29616354
Signalling pathways of the TNF superfamily: a double-edged swordQ29616428
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosisQ29616568
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in miceQ29617092
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectlyQ29617135
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclatureQ29618777
Apoptosis: controlled demolition at the cellular levelQ29620114
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosisQ29620466
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosisQ29620536
Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling ComplexQ30275663
Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein familyQ30370948
The N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis RegulationQ30387749
A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosisQ30483178
Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectorsQ31120935
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.Q35566028
The BCL-2 family reunionQ35568029
Mutational analysis of vaccinia virus E3 protein: the biological functions do not correlate with its biochemical capacity to bind double-stranded RNAQ35641511
Pathogeneses of respiratory infections with virulent and attenuated vaccinia virusesQ35663339
Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy ReceptorsQ35783059
The MC159 protein from the molluscum contagiosum poxvirus inhibits NF-κB activation by interacting with the IκB kinase complexQ35785785
Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.Q35830193
Orthopoxvirus fusion inhibitor glycoprotein SPI-3 (open reading frame K2L) contains motifs characteristic of serine proteinase inhibitors that are not required for control of cell fusionQ35847230
Rescue of vaccinia virus lacking the E3L gene by mutants of E3L.Q35849390
Characterization of a myxoma virus-encoded serpin-like protein with activity against interleukin-1 beta-converting enzymeQ35867781
Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene productQ35869096
Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.Q35878092
Programmed cell death in animal development and diseaseQ35878720
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.Q35880175
The amino terminus of the vaccinia virus E3 protein is necessary to inhibit the interferon responseQ35943615
ER stress and the unfolded protein responseQ35986601
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosisQ35990527
Phosphatidylserine dynamics in cellular membranesQ35998609
Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosisQ36264708
The Molluscum Contagiosum Virus protein MC163 localizes to the mitochondria and dampens mitochondrial mediated apoptotic responsesQ36290498
The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functionsQ36351550
Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.Q36363353
Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virusQ36371279
The myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore.Q36371468
M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytesQ36404366
Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesisQ36424460
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infectionQ36432681
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationQ36496658
Intermolecular duplexes formed from polyadenylylated vaccinia virus RNA.Q36497272
Mitochondrial fission and apoptosis: an ongoing trial.Q36500660
Mechanism of Synthesis of Vaccinia Virus Double-Stranded Ribonucleic Acid In Vivo and In VitroQ36577589
Multigenic evasion of inflammation by poxvirusesQ36629763
Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L geneQ36765625
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.Q42598497
Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptorQ42601211
Myxoma virus M11L ORF encodes a protein for which cell surface localization is critical in manifestation of viral virulenceQ42604229
Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genesQ42632586
Vaccinia virus encodes a family of genes with homology to serine proteinase inhibitorsQ42647197
The genome of molluscum contagiosum virus: analysis and comparison with other poxvirusesQ42659074
Vaccinia virus serpins B13R (SPI-2) and B22R (SPI-1) encode M(r) 38.5 and 40K, intracellular polypeptides that do not affect virus virulence in a murine intranasal modelQ42688524
Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L.Q42807639
The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulationQ44206768
Leporipoxvirus Cu,Zn-superoxide dismutase (SOD) homologs are catalytically inert decoy proteins that bind copper chaperone for SOD.Q44457878
Complementation of vaccinia virus deleted of the E3L gene by mutants of E3L.Q44504510
A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responsesQ44610042
Cowpox virus CrmA, Myxoma virus SERP2 and baculovirus P35 are not functionally interchangeable caspase inhibitors in poxvirus infectionsQ44857048
Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virusQ45034493
RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosisQ45368726
Spontaneous regression of highly immunogenic Molluscum contagiosum virus (MCV)-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltrationQ45373465
Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cellsQ45395541
Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosisQ45437312
The N-terminal domain of the vaccinia virus E3L-protein is required for neurovirulence, but not induction of a protective immune responseQ45510140
Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 proteinQ45738159
Myxoma virus expresses a TNF receptor homolog with two distinct functionsQ45740282
Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alphaQ45768255
Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA.Q45779943
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.Q45785971
Double-stranded RNA in Vaccinia Virus Infected CellsQ45810024
Reversible inactivation and reactivation of vaccinia virus by manipulation of viral lipid compositionQ45827779
A vaccinia serine protease inhibitor which prevents virus-induced cell fusionQ45867906
Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signalingQ46442224
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell deathQ46839351
Mitochondrial membrane potential at HL-60 cell apoptosis induced by cytarabineQ46844168
A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegansQ47069275
Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivoQ47070611
Major apoptotic mechanisms and genes involved in apoptosisQ38802454
Functional Comparison of Molluscum Contagiosum Virus vFLIP MC159 with Murine Cytomegalovirus M36/vICA and M45/vIRA ProteinsQ38807626
Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infectionQ38968870
Vaccinia virus entry is followed by core activation and proteasome-mediated release of the immunomodulatory effector VH1 from lateral bodiesQ39119835
Vaccinia virus evasion of regulated cell death.Q39213877
Caspase-dependent non-apoptotic processes in developmentQ39318015
dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8.Q39378876
Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.Q39379660
The envelope of vaccinia virus reveals an unusual phospholipid in Golgi complex membranes.Q39432564
Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.Q39446101
The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitorsQ39455647
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPsQ39511129
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificityQ39694237
Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3.Q39697230
Viral host-range factor C7 or K1 is essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiationQ39784904
Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell FateQ39833736
MAVS-mediated apoptosis and its inhibition by viral proteinsQ39858569
Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C releaseQ39947961
Targeting the retinoblastoma protein by MC007L, gene product of the molluscum contagiosum virus: detection of a novel virus-cell interaction by a member of the poxviruses.Q39950893
Amsacta moorei entomopoxvirus expresses an active superoxide dismutaseQ39991443
Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses.Q40000006
TLR3 can directly trigger apoptosis in human cancer cells.Q40296182
Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamicsQ40303654
Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondriaQ40329192
The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosisQ40330298
The MCV MC159 protein inhibits late, but not early, events of TNF-α-induced NF-κB activationQ40393980
Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptorsQ40542008
Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak.Q40545931
The modification and assembly of proteins in the endoplasmic reticulumQ40619093
Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced feverQ40655167
The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host rangeQ40712234
The vaccinia virus N1L protein is an intracellular homodimer that promotes virulenceQ40717481
MC159L protein from the poxvirus molluscum contagiosum virus inhibits NF-kappaB activation and apoptosis induced by PKR.Q40767568
Characterization and functional analysis of Serp3: a novel myxoma virus-encoded serpin involved in virulence.Q40803819
The role of conformational change in serpin structure and functionQ40850531
The cowpox virus serpin SPI-3 complexes with and inhibits urokinase-type and tissue-type plasminogen activators and plasminQ40870841
Vaccinia virus serpin-1 deletion mutant exhibits a host range defect characterized by low levels of intermediate and late mRNAsQ40926197
Vaccinia virus E3L protein is an inhibitor of the interferon (i.f.n.)-induced 2-5A synthetase enzyme.Q41047354
Ultraviolet-induced cell death blocked by a selenoprotein from a human dermatotropic poxvirus.Q41070248
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cellsQ41157654
The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA geneQ41225859
M-T2: a poxvirus TNF receptor homologue with dual activities.Q41300846
Distinct patterns of IFN sensitivity observed in cells infected with vaccinia K3L- and E3L- mutant virusesQ41326428
The myxoma virus TNF-receptor homologue (T2) inhibits tumor necrosis factor-alpha in a species-specific fashionQ41431396
The effects of serpin gene mutations on the distinctive pathobiology of cowpox and rabbitpox virus following intranasal inoculation of Balb/c mice.Q41517808
SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammationQ41537128
The interferon-induced double-stranded RNA-activated human p68 protein kinase inhibits the replication of vaccinia virusQ41564323
Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding proteinQ41599320
Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death.Q41825243
The double-stranded RNA binding domain of the vaccinia virus E3L protein inhibits both RNA- and DNA-induced activation of interferon betaQ41895976
Vaccinia-induced epidermal growth factor receptor-MEK signalling and the anti-apoptotic protein F1L synergize to suppress cell death during infectionQ42023832
iRHOM2 is a critical pathogenic mediator of inflammatory arthritisQ42056708
Structural study of the RIPoptosome core reveals a helical assembly for kinase recruitmentQ42173418
Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA virusesQ42425012
Inhibition of human caspases by peptide-based and macromolecular inhibitorsQ42538024
Vaccinia virus encodes two proteins that are structurally related to members of the plasma serine protease inhibitor superfamilyQ36780589
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranesQ36799170
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activationQ36835632
Viral subversion of apoptotic enzymes: escape from death row.Q36925632
Recurrent overexpression of c-IAP2 in EBV-associated nasopharyngeal carcinomas: critical role in resistance to Toll-like receptor 3-mediated apoptosisQ36944175
Regulation of mitochondrial morphological dynamics during apoptosis by Bcl-2 family proteins: a key in Bak?Q37029727
Oncolytic myxoma virus: the path to clinicQ37126088
Poxvirus MC160 protein utilizes multiple mechanisms to inhibit NF-kappaB activation mediated via components of the tumor necrosis factor receptor 1 signal transduction pathway.Q37127938
PERK and PKR: old kinases learn new tricksQ37140418
Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus MutantsQ37182678
Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptorsQ37188519
Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathwaysQ37232811
Direct formation of vaccinia virus membranes from the endoplasmic reticulum in the absence of the newly characterized L2-interacting protein A30.5.Q37254298
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptorQ37308429
Appraising the apoptotic mimicry model and the role of phospholipids for poxvirus entryQ37359610
Innate immunity to virus infection.Q37361448
Inhibition of tumor growth by polyinosinic-polycytidylic acidQ37422712
Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus.Q37495190
Emerging role for members of the Bcl-2 family in mitochondrial morphogenesisQ37633650
The distribution and function of phosphatidylserine in cellular membranesQ37700664
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat.Q37814626
Poxvirus host cell entry.Q37996243
PKR-dependent inflammatory signalsQ38054995
The multiple faces of proteinkinase R in antiviral defenseQ38073624
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicityQ38133695
The impact of PKR activation: from neurodegeneration to cancer.Q38187546
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.Q38302674
Myxoma virus T2 protein, a tumor necrosis factor (TNF) receptor homolog, is secreted as a monomer and dimer that each bind rabbit TNFalpha, but the dimer is a more potent TNF inhibitorQ38356806
Immune evasion strategies of molluscum contagiosum virus.Q38363426
Viral apoptotic mimicryQ38520018
Leporipoxvirus Cu-Zn superoxide dismutase homologs inhibit cellular superoxide dismutase, but are not essential for virus replication or virulenceQ38522699
The cowpox virus SPI-3 and myxoma virus SERP1 serpins are not functionally interchangeable despite their similar proteinase inhibition profiles in vitroQ38526232
Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virusQ38755173
Recombinant Poxvirus and the Tumor Microenvironment: Oncolysis, Immune Regulation and Immunization.Q51007512
Variation in ligand binding specificities of a novel class of poxvirus-encoded tumor necrosis factor-binding protein.Q52669186
Solution NMR Investigation of the CD95/FADD Homotypic Death Domain Complex Suggests Lack of Engagement of the CD95 C TerminusQ57976043
Immunosuppressive effects of apoptotic cellsQ59060221
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosisQ61565711
The interferon-induced double-stranded RNA-activated protein kinase induces apoptosisQ71613218
A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosisQ73201734
Inhibition of fas death signals by FLIPsQ77485563
Toll-like receptor 3 expressed by melanoma cells as a target for therapy?Q80726153
Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosisQ80795514
Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signalingQ81550639
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue8
P921main subjectapoptotic processQ14599311
PoxviridaeQ948421
evasion of host immune responseQ1660157
host-pathogen interactionQ5909198
Poxviridae infectious diseaseQ12353899
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P577publication date2017-08-08
P1433published inVirusesQ7935305
P1476titlePoxviruses Utilize Multiple Strategies to Inhibit Apoptosis
P478volume9

Reverse relations

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