Vaccinia virus inhibits NF-κB-dependent gene expression downstream of p65 translocation.

scientific article

Vaccinia virus inhibits NF-κB-dependent gene expression downstream of p65 translocation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02627-13
P932PMC publication ID3957909
P698PubMed publication ID24371075

P50authorGeoffrey Lilley SmithQ5069186
Carlos Maluquer de MotesQ42150779
P2093author name stringRebecca P Sumner
David L Veyer
P2860cites workA candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responsesQ21135240
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic proteinQ24305049
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14Q24312867
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7Q24338222
Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than ApoptosisQ27651621
Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7Q27658172
Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to VirulenceQ27676390
Pathogen recognition and innate immunityQ27861084
IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitinationQ28249343
Shared principles in NF-kappaB signalingQ29547234
Regulation and function of NF-kappaB transcription factors in the immune systemQ29616427
Proteomic screening of variola virus reveals a unique NF-kappaB inhibitor that is highly conserved among pathogenic orthopoxvirusesQ33447166
Vaccinia virus strains Lister, USSR and Evans express soluble and cell-surface tumour necrosis factor receptorsQ45749924
A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infectionQ45872018
Down regulation of gene expression by the vaccinia virus D10 protein.Q33639877
Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding proteinQ34182371
Poxvirus genomes: a phylogenetic analysisQ34289377
A nuclear inhibitor of NF-kappaB encoded by a poxvirusQ34457951
A vaccinia virus deletion mutant reveals the presence of additional inhibitors of NF-kappaB.Q34485252
Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulenceQ34611139
Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxvirusesQ34690881
Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells.Q35024097
Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in miceQ35943846
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defenseQ36370571
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulenceQ36403362
Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence.Q36523222
Escherichia coli gpt gene provides dominant selection for vaccinia virus open reading frame expression vectorsQ36868255
Vaccinia virus gene D8 encodes a virion transmembrane proteinQ36873069
The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunitiesQ36942054
A virulence factor of myxoma virus colocalizes with NF-kappaB in the nucleus and interferes with inflammationQ36954546
Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infectionQ37006800
The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradationQ37010771
Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulenceQ37109669
Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor necrosis factor alpha but is independent of its host range functionQ37157179
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chainsQ37191956
Walleye dermal sarcoma virus rv-cyclin inhibits NF-kappaB-dependent transcriptionQ37223860
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.Q37421291
How vaccinia virus has evolved to subvert the host immune response.Q37855047
Viral interference with innate immunity by preventing NF-κB activityQ37952350
Regulation of NF‐κB by ubiquitination and degradation of the IκBsQ37995680
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicityQ38133695
Vaccinia virus strain Western Reserve protein B14 is an intracellular virulence factorQ40280952
A238L inhibits NF-ATc2, NF-kappa B, and c-Jun activation through a novel mechanism involving protein kinase C-theta-mediated up-regulation of the amino-terminal transactivation domain of p300.Q40427893
Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus AnkaraQ40506182
Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptorsQ40542008
The vaccinia virus N1L protein is an intracellular homodimer that promotes virulenceQ40717481
Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activationQ40781958
Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding proteinQ41599320
Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection.Q42258950
Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacyQ42280143
Vaccinia virus gene A36R encodes a M(r) 43-50 K protein on the surface of extracellular enveloped virusQ42601218
Deletion of 55 open reading frames from the termini of vaccinia virusQ42626327
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectvaccinia virusQ1986297
NF-κBQ411114
P304page(s)3092-3102
P577publication date2013-12-26
P1433published inJournal of VirologyQ1251128
P1476titleVaccinia virus inhibits NF-κB-dependent gene expression downstream of p65 translocation
P478volume88

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cites work (P2860)
Q59351861A novel class of viral Ankyrin proteins targeting the host E3 ubiquitin ligase Cullin-2
Q40090682A parapoxviral virion protein inhibits NF-κB signaling early in infection
Q89621198Cullin-5 Adaptor SPSB1 Controls NF-κB Activation Downstream of Multiple Signaling Pathways
Q64121653HSV-1\EGFP stimulates miR-146a expression in a NF-κB-dependent manner in monocytic THP-1 cells
Q64935347IIV-6 Inhibits NF-κB Responses in Drosophila.
Q37255121Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators
Q35763016Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence.
Q38704029Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.
Q37296099Multiple Bcl-2 family immunomodulators from vaccinia virus regulate MAPK/AP-1 activation
Q64092200NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation
Q35652144Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.
Q28082629Recent advances on viral manipulation of NF-κB signaling pathway
Q34490252Redundancy complicates the definition of essential genes for vaccinia virus
Q91983844Vaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-κB Activation and Inhibits CD8+ T-Cell Memory
Q45325861Vaccinia virus protein A49 activates Wnt signalling by targetting the E3 ligase β-TrCP.
Q52680807Virulent poxviruses inhibit DNA sensing by preventing STING activation

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