Vaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-κB Activation and Inhibits CD8+ T-Cell Memory

scientific article published on 01 May 2019

Vaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-κB Activation and Inhibits CD8+ T-Cell Memory is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00051-19
P932PMC publication ID6498060
P698PubMed publication ID30814284

P50authorGeoffrey Lilley SmithQ5069186
Carlos Maluquer de MotesQ42150779
P2093author name stringHongwei Ren
Laura Gonzalez
Zihan Zhu
Mitchell A Pallett
Rui-Yao Zhang
Simon R Scutts
P2860cites workCrystal structure of the BTB domain from PLZFQ22003945
Identification of the receptor component of the IkappaBalpha-ubiquitin ligaseQ22008569
NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4Q24293000
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14Q24312867
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activationQ24315019
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7Q24338222
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitroQ24608829
The Regulation of NF-κB Subunits by PhosphorylationQ26752951
The kelch repeat superfamily of proteins: propellers of cell functionQ28140778
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradationQ28302850
Simultaneous high-resolution analysis of vaccinia virus and host cell transcriptomes by deep RNA sequencingQ33953053
Crystal structure of a free radical enzyme, galactose oxidaseQ34060750
Transcriptional control of effector and memory CD8+ T cell differentiationQ34064074
The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infectionQ34596147
Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulenceQ34611139
Enhancement of CD8(+) T-cell memory by removal of a vaccinia virus nuclear factor-κB inhibitor.Q35512353
Cullin-3 regulates late endosome maturation.Q35735068
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.Q35740993
Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2Q36210308
The Replication Defect of ICP0-Null Mutant Herpes Simplex Virus 1 Can Be Largely Complemented by the Combined Activities of Human Cytomegalovirus Proteins IE1 and pp71Q36559546
Hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B.Q37051589
Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signalingQ37713967
Interaction of orthopoxviruses with the cellular ubiquitin-ligase system.Q37779516
Poxvirus exploitation of the ubiquitin-proteasome systemQ37945194
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicityQ38133695
Vaccinia virus inhibits NF-κB-dependent gene expression downstream of p65 translocation.Q38326055
Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB.Q38717199
Memory CD8(+) T Cells: Innate-Like Sensors and Orchestrators of ProtectionQ38821764
Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation.Q38822781
Importin β1 targeting by hepatitis C virus NS3/4A protein restricts IRF3 and NF-κB signaling of IFNB1 antiviral responseQ38906502
Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling NegativelyQ39624592
NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha moleculesQ39984698
Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response.Q40122897
Vaccinia virus kelch protein A55 is a 64 kDa intracellular factor that affects virus-induced cytopathic effect and the outcome of infection in a murine intradermal model.Q40280943
Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathwaysQ41843640
Vaccinia virus gene A36R encodes a M(r) 43-50 K protein on the surface of extracellular enveloped virusQ42601218
A model for vaccinia virus pathogenesis and immunity based on intradermal injection of mouse ear pinnaeQ43646853
KPNB1, XPO7 and IPO8 Mediate the Translocation ofNF‐κB/p65 into the NucleusQ45049084
The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal modelQ45722229
Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routesQ45731710
Activation of the Innate Immune Receptors: Guardians of the Micro Galaxy : Activation and Functions of the Innate Immune Receptors.Q47943969
Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55Q64088977
P4510describes a project that usesImageJQ1659584
P433issue10
P921main subjectvaccinia virusQ1986297
NF-κBQ411114
P577publication date2019-05-01
P1433published inJournal of VirologyQ1251128
P1476titleVaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-κB Activation and Inhibits CD8+ T-Cell Memory
P478volume93

Reverse relations

cites work (P2860)
Q89889589Leaky scanning translation generates a second A49 protein that contributes to vaccinia virus virulence
Q90041633USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2

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