Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism

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Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1000280
P3181OpenCitations bibliographic resource ID849363
P932PMC publication ID2627925
P698PubMed publication ID19180189
P5875ResearchGate publication ID23960234

P2093author name stringMichele E Hardy
Joel W Graff
Khalil Ettayebi
P2860cites workMdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53Q22253350
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusQ24336255
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradationQ24523761
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavageQ24546084
Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3Q24555785
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerQ24648025
PML residue lysine 160 is required for the degradation of PML induced by herpes simplex virus type 1 regulatory protein ICP0Q24674847
Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7Q24683021
Alpha-herpesvirus infection induces the formation of nuclear actin filamentsQ27320136
A Single Amino Acid Substitution in the West Nile Virus Nonstructural Protein NS2A Disables Its Ability To Inhibit Alpha/Beta Interferon Induction and Attenuates Virus Virulence in MiceQ27473041
Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. A new structural class of zinc-fingerQ27731229
Mechanisms underlying ubiquitinationQ27860656
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Q27861127
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.Q27863647
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuliQ28116145
Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alphaQ28143121
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligaseQ28145635
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF ComplexQ28210666
Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signalingQ28216569
Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cellsQ28237026
Elevated expression of Wnt antagonists is a common event in hepatoblastomasQ28256831
Interferons at age 50: past, current and future impact on biomedicineQ28259312
Comparative analysis of the rotavirus NS53 gene: conservation of basic and cysteine-rich regions in the protein and possible stem-loop structures in the RNAQ28263798
KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cellsQ28269339
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motifQ28276184
Zinc-binding domain of rotavirus NSP1 is required for proteasome-dependent degradation of IRF3 and autoregulatory NSP1 stabilityQ28284962
Rotavirus double-stranded RNA induces apoptosis and diminishes wound repair in rat intestinal epithelial cellsQ28571181
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivoQ28609049
Shared principles in NF-kappaB signalingQ29547234
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIFQ29547901
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylationQ29614709
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasuresQ29615028
Associations Among  -TrCP, an E3 Ubiquitin Ligase Receptor,  -Catenin, and NF- B in Colorectal CancerQ30051055
Scores of RINGS but No PHDs in Ubiquitin SignalingQ30917234
Influenza A and B viruses expressing altered NS1 proteins: A vaccine approachQ33895154
Induction of apoptosis in HT-29 cells infected with SA-11 rotavirusQ60274049
Genomic Heterogeneity of Simian Rotavirus SA11Q70197999
The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradationQ81304838
IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNAQ34029053
Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.Q34330967
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signalingQ34361655
Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genesQ34365709
Rotavirus vaccines: current prospects and future challengesQ34550164
Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replicationQ34717075
Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1Q35667107
The interferon response circuit: induction and suppression by pathogenic virusesQ36346824
Viral hijacking of cellular ubiquitination pathways as an anti-innate immunity strategyQ36598889
Manipulation of the nuclear factor-kappaB pathway and the innate immune response by virusesQ36637910
Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes.Q37596474
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.Q39548922
The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradationQ39596942
Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1.Q39684543
Gene expression pattern in Caco-2 cells following rotavirus infection.Q39752806
Role of alpha/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteinsQ39789324
Nondefective rotavirus mutants with an NSP1 gene which has a deletion of 500 nucleotides, including a cysteine-rich zinc finger motif-encoding region (nucleotides 156 to 248), or which has a nonsense codon at nucleotides 153-155.Q39874852
Cell culture propagation of porcine rotavirus (reovirus-like agent)Q40115812
Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathwayQ40170925
Antigenic relationships among some bovine rotaviruses: serum neutralization and cross-protection in gnotobiotic calvesQ40216375
Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activationQ40721352
The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.Q40808240
Paramyxoviridae use distinct virus-specific mechanisms to circumvent the interferon responseQ40831794
Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.Q40927249
Regulation of type I interferon gene expression by interferon regulatory factor-3.Q41063455
Induction of apoptosis in HT-29 cells infected with SA-11 rotavirusQ41149080
Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteinsQ45751210
Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.Q50335887
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesPorcine rotavirus OSUQ112246255
Bovine rotavirus strain NCDVQ113434050
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectRotavirusQ164778
modulation by virus of host processQ14818042
Rotavirus non-structural protein 1Q24724262
P304page(s)e1000280
P577publication date2009-01-01
P1433published inPLOS PathogensQ283209
P1476titleRotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism
P478volume5

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