Associations Among  -TrCP, an E3 Ubiquitin Ligase Receptor,  -Catenin, and NF- B in Colorectal Cancer

scientific article (publication date: 3 August 2004)

Associations Among  -TrCP, an E3 Ubiquitin Ligase Receptor,  -Catenin, and NF- B in Colorectal Cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/JNCI/DJH219
P3181OpenCitations bibliographic resource ID3380291
P698PubMed publication ID15292388
P5875ResearchGate publication ID8418964

P2093author name stringA. Ougolkov
B. Zhang
K. Yamashita
M. Mai
S. Y. Fuchs
T. Minamoto
V. Bilim
P2860cites workFamilial Parkinson disease gene product, parkin, is a ubiquitin-protein ligaseQ22254584
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligaseQ24290903
Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-UQ24672630
The ubiquitin systemQ27860803
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.Q28118570
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27Q28137813
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27Q28137860
The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesisQ28138414
beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formationQ28144504
Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumorsQ28145273
The Hedgehog and Wnt signalling pathways in cancerQ28189485
Beta-catenin--a linchpin in colorectal carcinogenesis?Q28198211
Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100Q28216699
Apoptosis in the pathogenesis and treatment of diseaseQ28235731
Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 geneQ28506095
beta-catenin is a target for the ubiquitin-proteasome pathwayQ29547589
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
NF-kappaB in cancer: from innocent bystander to major culpritQ29614603
NF-kappaB at the crossroads of life and deathQ29619302
The oncogenic activation of beta-cateninQ33540073
Ubiquitin-mediated proteolysis: biological regulation via destructionQ33910576
NF-kappaB/rel/IkappaB: implications in gastrointestinal diseasesQ33930920
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environmentQ33943198
Detection of oncogenes in the diagnosis of cancers with active oncogenic signalingQ34162584
Blocking oncogenic Ras signaling for cancer therapyQ34311585
MDM2: life without p53.Q34326204
Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancerQ34415244
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.Q34415250
Ubiquitin-mediated degradation of cellular proteins in health and diseaseQ34490180
p53-Mdm2--the affair that never endsQ34605732
Emerging concepts in colorectal neoplasiaQ34800070
Tumor formation by genetic mutations in the components of the Wnt signaling pathwayQ35161748
The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancerQ35691542
IkappaB kinase: beginning, not the endQ36039922
Inhibition of HOS expression and activities by Wnt pathwayQ40750211
Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB.Q40803270
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cellsQ40918524
The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.Q40967633
Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligaseQ42631679
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.Q48354837
Basic Medical Research Award. The ubiquitin systemQ48372080
Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.Q50335887
Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex.Q52103792
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.Q52826936
Strongly reduced expression of the cell cycle inhibitor p27 in endometrial neoplasia.Q53421954
Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC.Q54541774
APC/CTNNB1 (?-catenin) pathway alterations in human prostate cancersQ57693627
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
P304page(s)1161-1170
P577publication date2004-08-03
P1433published inJournal of the National Cancer InstituteQ400279
P1476titleAssociations Among  -TrCP, an E3 Ubiquitin Ligase Receptor,  -Catenin, and NF- B in Colorectal Cancer
P478volume96

Reverse relations

cites work (P2860)
Q41712580A new layer of degradation mechanism for PR-Set7/Set8 during cell cycle
Q38084210A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer
Q58164878A positive feedback loop between hepatocyte growth factor receptor and β-catenin sustains colorectal cancer cell invasive growth
Q37217655Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation
Q40266758CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling
Q48216286Centromere protein W interacts with beta-transducin repeat-containing protein 1 and modulates its subcellular localization.
Q34127839Circadian gene variants in cancer.
Q24294824Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells
Q37096504Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer
Q37891671Cross-Regulation Between Wnt and NF-κB Signaling Pathways
Q52715797Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis.
Q28074708Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation
Q53690290DNA Damage Inducible Transcript 4 Gene: The Switch of the Metabolism as Potential Target in Cancer.
Q24648025Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
Q30278581Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis
Q89791100Design and synthesis of new energy restriction mimetic agents: Potent anti-tumor activities of hybrid motifs of aminothiazoles and coumarins
Q40017813Differential effect of NF-kappaB activity on beta-catenin/Tcf pathway in various cancer cells
Q28086796Dysregulation of ubiquitin ligases in cancer
Q35082710E3 ubiquitin ligases as cancer targets and biomarkers
Q47636038E3 ubiquitin ligases in cancer and implications for therapies
Q34441649Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1
Q38785208Estrogen and ERα enhanced β-catenin degradation and suppressed its downstream target genes to block the metastatic function of HA22T hepatocellular carcinoma cells via modulating GSK-3β and β-TrCP expression.
Q53060819Expression of targeted ribozyme against telomerase RNA causes altered expression of several other genes in tumor cells.
Q35758175Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis
Q61810405FBXO22 Suppresses Metastasis in Human Renal Cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated Angiogenesis
Q51533176FBXO25 promotes cell proliferation, invasion, and migration of NSCLC.
Q92856149FBXW5 Promotes Tumorigenesis and Metastasis in Gastric Cancer via Activation of the FAK-Src Signaling Pathway
Q33689786Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine
Q52349771Fbxw11 promotes the proliferation of lymphocytic leukemia cells through the concomitant activation of NF-κB and β-catenin/TCF signaling pathways.
Q50026061Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer
Q37330990Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells
Q39450022Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine
Q38823288Hint1 Up-Regulates IκBα by Targeting the β-TrCP Subunit of SCF E3 Ligase in Human Hepatocellular Carcinoma Cells.
Q34635123Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming
Q50974518Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics.
Q37320122MicroRNA binding site polymorphisms as biomarkers of cancer risk
Q38577492MicroRNA regulation of F-box proteins and its role in cancer.
Q35011051Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
Q28512155Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule
Q37995696NF-κB and the link between inflammation and cancer
Q39766076Nuclear factor-kappa B inhibition reduces markedly cell proliferation in Epstein-Barr virus-infected stomach cancer, but affects variably in Epstein-Barr virus-negative stomach cancer
Q35757254Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors.
Q28209990Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2
Q39235953Prolonged exposure to acid and bile induces chromosome abnormalities that precede malignant transformation of benign Barrett's epithelium
Q28390295REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase
Q38828721Recent advances in SCF ubiquitin ligase complex: Clinical implications
Q48375223Reciprocal regulation between βTrCP and Smurf1 suppresses proliferative capacity of liver cancer cells.
Q39921991Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2.
Q33988164Retracted: Silymarin Targets β-Catenin Signaling in Blocking Migration/Invasion of Human Melanoma Cells
Q35012352Roles of F-box proteins in cancer
Q21090517Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism
Q54982486S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer.
Q35613215SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection
Q36119281SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB.
Q53118754SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells.
Q38435553Seten: a tool for systematic identification and comparison of processes, phenotypes, and diseases associated with RNA-binding proteins from condition-specific CLIP-seq profiles.
Q47128996Significance of the E3 ubiquitin protein UBR5 as an oncogene and a prognostic biomarker in colorectal cancer.
Q64259739Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location
Q91928988Targeting the Canonical WNT/β-Catenin Pathway in Cancer Treatment Using Non-Steroidal Anti-Inflammatory Drugs
Q26866185Targeting the ubiquitin pathway for cancer treatment
Q33419571The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity
Q36029051The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis
Q92446155The Role of Ubiquitination in Regulating Embryonic Stem Cell Maintenance and Cancer Development
Q24324551The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation
Q38087182The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer
Q37591349The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor
Q36420150Therapeutic intervention of proanthocyanidins on the migration capacity of melanoma cells is mediated through PGE2 receptors and β-catenin signaling molecules
Q29617992Ubiquitin ligases: cell-cycle control and cancer
Q33233938Ubiquitous mitochondrial creatine kinase downregulated in oral squamous cell carcinoma
Q33839776Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin
Q39779371Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA.
Q33530099beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor
Q89611790lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer
Q98384399β-TrCP suppresses the migration and invasion of trophoblast cells in preeclampsia by down-regulating Snail
Q49357675β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer

Search more.