lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer

scientific article published on 11 January 2020

lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.OMTN.2019.11.035
P932PMC publication ID7013141
P698PubMed publication ID32036249

P2093author name stringKai Li
Huanjie Yang
Qingzhu Yang
Chen Zhao
Xuemei Huang
Xinyuan Li
Yu Mei
Lin Jiao
P2860cites workGEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.Q38838244
The Dual Roles of NRF2 in Cancer.Q38855289
Linking Long Noncoding RNA Localization and FunctionQ38921242
Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation.Q38926773
Cancer stem cells: The root of tumor recurrence and metastases.Q39160322
Pancreatic Ductal Adenocarcinoma: Current and Evolving TherapiesQ39390859
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.Q39606140
Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.Q39733200
Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatinQ40051119
CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway.Q40076996
Nuclear Long Noncoding RNAs: Key Regulators of Gene ExpressionQ49715418
Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancerQ49747284
Antisense lncRNA As-SLC7A11 suppresses epithelial ovarian cancer progression mainly by targeting SLC7A11.Q50018250
Somatic mutations of the KEAP1 gene in common solid cancers.Q53659826
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.Q55339077
Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagyQ64073193
Nrf2 in cancers: A double-edged sword.Q64891831
CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinomaQ86018422
NRF2 and the Hallmarks of CancerQ88582817
Cancer statistics, 2019Q90941571
Microenvironmental Regulation of Long Noncoding RNA LINC01133 Promotes Cancer Stem Cell-Like Phenotypic Traits in Triple-Negative Breast CancersQ91702604
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligaseQ24558689
Eyes wide open: a critical review of sphere-formation as an assay for stem cellsQ24631827
Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell ResistanceQ26774916
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Reactive oxygen species in cancer stem cellsQ26849216
Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cellsQ28237026
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisQ28242612
Association of reactive oxygen species levels and radioresistance in cancer stem cellsQ29617812
Associations Among  -TrCP, an E3 Ubiquitin Ligase Receptor,  -Catenin, and NF- B in Colorectal CancerQ30051055
Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cellsQ33527780
Preparation of cytoplasmic and nuclear RNA from tissue culture cellsQ34022638
Methylation of the KEAP1 gene promoter region in human colorectal cancerQ34156322
Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapyQ34993085
Roles of F-box proteins in cancerQ35012352
Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasisQ35192383
The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancerQ35212896
Long noncoding RNA MALAT-1 enhances stem cell-like phenotypes in pancreatic cancer cellsQ35585395
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.Q36467640
Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.Q36563349
Trafficking of the transcription factor Nrf2 to promyelocytic leukemia-nuclear bodies: implications for degradation of NRF2 in the nucleusQ36850393
The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressorQ37591349
Overcoming nucleoside analog chemoresistance of pancreatic cancer: a therapeutic challengeQ37994505
Neat1 is a p53-inducible lincRNA essential for transformation suppressionQ38683437
Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cellsQ38697454
Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade.Q38739429
LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathwayQ38792198
P4510describes a project that usesImageJQ1659584
P921main subjectpancreatic cancerQ212961
P304page(s)974-985
P577publication date2020-01-11
P1433published inMolecular Therapy. Nucleic acidsQ27724110
P1476titlelncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer
P478volume19

Reverse relations

Q97419621LncRNA SLC7A11-AS1 Contributes to Lung Cancer Progression Through Facilitating TRAIP Expression by Inhibiting miR-4775cites workP2860