Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells

scientific article published on 21 November 2018

Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.39494
P932PMC publication ID6289572
P698PubMed publication ID30460894

P50authorRichard FlavellQ2149481
Siyuan DingQ55189576
Harry B. GreenbergQ55950186
P2093author name stringBin Li
Xiaomei Ge
Shu Zhu
Yanhua Song
Lili Ren
Ningguo Feng
P2860cites workRotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonismQ21090517
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunityQ24296473
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4Q24313563
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune responseQ24316320
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionQ24318426
RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epitheliumQ24321688
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusQ24336255
MAVS protein is attenuated by rotavirus nonstructural protein 1Q24339399
Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3Q24555785
Regulation of type I interferon responsesQ26853177
The battle between rotavirus and its host for control of the interferon signaling pathwayQ27006920
Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and PathophysiologyQ27321169
Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursorQ27478302
Structural basis for the prion-like MAVS filaments in antiviral innate immunityQ27681906
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA virusesQ27860455
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Q27861127
RIG-I in RNA virus recognitionQ28081618
VISA is an adapter protein required for virus-triggered IFN-beta signalingQ28131814
PhosphoSitePlus, 2014: mutations, PTMs and recalibrationsQ28254001
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activationQ28256216
IFN-lambda determines the intestinal epithelial antiviral host defenseQ28508039
Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 ComplexQ28554481
MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virusQ28593715
Convergent evolution of escape from hepaciviral antagonism in primatesQ28731324
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosomeQ30588597
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cellsQ33289420
Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.Q33650989
Analysis of host range restriction determinants in the rabbit model: comparison of homologous and heterologous rotavirus infections.Q33782483
Diverse intracellular pathogens activate type III interferon expression from peroxisomesQ33933986
Predicted structure and domain organization of rotavirus capping enzyme and innate immune antagonist VP3Q34059087
Different rotavirus strains enter MA104 cells through different endocytic pathways: the role of clathrin-mediated endocytosis.Q34120236
MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptorsQ34280734
IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signalingQ34539832
Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responsesQ34649632
NLRX1 is a regulator of mitochondrial antiviral immunityQ34737001
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome ActivationQ57258441
Psoralen preparation of antigenically intact noninfectious rotavirus particlesQ67493693
The specific and essential role of MAVS in antiviral innate immune responsesQ83817506
Characterization of rotavirus RNAs that activate innate immune signaling through the RIG-I-like receptorsQ34874614
Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsisQ35152251
RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responsesQ35343462
Proteolytic cleavage of chemerin protein is necessary for activation to the active form, Chem157S, which functions as a signaling molecule in glioblastomaQ35604419
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C VirusQ35847364
An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune responseQ35898500
Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus InfectionsQ36003428
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infectionQ36108222
Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution.Q36483624
The mitochondrial antiviral signaling protein, MAVS, is cleaved during apoptosisQ37009664
The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signallingQ37031839
Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunityQ37088604
Rotavirus NSP1 mediates degradation of interferon regulatory factors through targeting of the dimerization domainQ37123575
MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and PathogenesisQ37174399
alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirusQ37272014
Rotavirus and reovirus modulation of the interferon responseQ37582939
Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expressionQ37610149
A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infectionQ37612580
A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of InfectionQ37621857
A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunityQ37648264
Hepatitis C virus NS3-4A inhibits the peroxisomal MAVS-dependent antiviral signalling response.Q38795132
Rotavirus Controls Activation of the 2'-5'-Oligoadenylate Synthetase/RNase L Pathway Using at Least Two Distinct MechanismsQ38832952
Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growthQ39035742
Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut.Q40209553
MAVS-dependent host species range and pathogenicity of human hepatitis A virus.Q40538547
The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial MatrixQ40605466
Liposome-mediated transfection of intact viral particles reveals that plasma membrane penetration determines permissivity of tissue culture cells to rotavirusQ41022034
HT-29 cells: a new substrate for rotavirus growthQ41704058
Roles of VP4 and NSP1 in determining the distinctive replication capacities of simian rotavirus RRV and bovine rotavirus UK in the mouse biliary tractQ41998682
MDA5 and MAVS mediate type I interferon responses to coxsackie B virus.Q42109953
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activityQ42285504
Permissive replication of homologous murine rotavirus in the mouse intestine is primarily regulated by VP4 and NSP1.Q43079549
The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradationQ45375900
Rotavirus degrades multiple type interferon receptors to inhibit IFN signaling and protects against mortality from endotoxin in suckling miceQ46605151
STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection.Q52319679
Peroxisomal MAVS activates IRF1-mediated IFN-λ productionQ57236572
P4510describes a project that usesImageJQ1659584
Human rotavirus DS1Q112252639
Bovine rotavirus strain UKQ113433734
Murine rotavirusQ113562395
simian rhesus rotavirusQ112242067
Simian rotavirus A/SA11Q112242768
Porcine rotavirus OSUQ112246255
Human rotavirus strain WAQ112246336
P407language of work or nameEnglishQ1860
P921main subjectRotavirusQ164778
modulation by virus of host processQ14818042
Protein VP3, rotavirusQ24770641
P577publication date2018-11-21
P1433published ineLifeQ2000008
P1476titleRotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells
P478volume7

Reverse relations

cites work (P2860)
Q92731019Aichi Virus Induces Antiviral Host Defense in Primary Murine Intestinal Epithelial Cells
Q114371081Cryo-EM Structure of Rotavirus VP3 Reveals Novel Insights into Its Role in RNA Capping and Endogenous Transcription
Q100387979Nitazoxanide and JIB-04 have broad-spectrum antiviral activity and inhibit SARS-CoV-2 replication in cell culture and coronavirus pathogenesis in a pig model
Q98243759Porcine deltacoronavirus (PDCoV) infection antagonizes interferon-λ1 production
Q91633508Profiling of rotavirus 3'UTR-binding proteins reveals the ATP synthase subunit ATP5B as a host factor that supports late-stage virus replication
Q89685625Reverse genetics reveals a role of the rotavirus VP3 phosphodiesterase activity in inhibiting RNase L signaling and contributing to intestinal viral replication in vivo
Q114370871Rotavirus Interactions With Host Intestinal Epithelial Cells
Q92376467Rotavirus Species B Encodes a Functional Fusion-Associated Small Transmembrane Protein
Q95602650TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes
Q94670006TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

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