Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage

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Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.02495-05
P932PMC publication ID1472616
P698PubMed publication ID16731946

P50authorJohn HiscottQ28322441
Damien VitourQ37342117
Rongtuan LinQ47696091
Peyman NakhaeiQ92260476
P2093author name stringPeter Wilkinson
Ilkka Julkunen
Qiang Sun
Long Yang
Judith Lacoste
Suzanne Paz
Eliane Meurs
P2860cites workHepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunityQ24296473
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionQ24318426
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusQ24336255
Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilonQ24519072
CARD games in apoptosis and immunityQ24522647
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradationQ24523761
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive propertiesQ24530264
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-IQ24556673
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoterQ24558779
Toll-like receptor signallingQ24570126
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Efficient initiation of HCV RNA replication in cell cultureQ27860520
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genomeQ27860719
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3Q27860854
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Q27861127
VISA is an adapter protein required for virus-triggered IFN-beta signalingQ28131814
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
Triggering the interferon antiviral response through an IKK-related pathwayQ28191761
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIFQ29547901
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signalingQ29614206
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virusQ29614207
Epidemiology of hepatitis C: geographic differences and temporal trendsQ29615896
Cell type-specific involvement of RIG-I in antiviral responseQ29615914
Immunology of hepatitis B virus and hepatitis C virus infectionQ29618957
Evasion of intracellular host defence by hepatitis C virusQ29618976
Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long-term outcomeQ29620780
To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon.Q30330124
Structure and function of the interferon-beta enhanceosomeQ33671579
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Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune responseQ34365418
Recent advances in the molecular biology of hepatitis C virusQ34417709
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblastsQ35122228
CARD proteins as therapeutic targets in cancerQ35767913
Discovery of small-molecule inhibitors of HCV NS3-4A protease as potential therapeutic agents against HCV infectionQ36266285
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infectionQ36402648
Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infectionQ36402672
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stabilityQ36557754
Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7.Q39455009
Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.Q40348165
Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.Q40678254
Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virusQ42987918
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
virologyQ7215
proteolysisQ33123
mitochondrionQ39572
hepatitis CQ154869
Hepatitis C virusQ708693
P304page(s)6072-83
P577publication date2006-06-01
P1433published inJournal of VirologyQ1251128
P1476titleDissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage
P478volume80

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