| scholarly article | Q13442814 |
| P356 | DOI | 10.1128/JVI.00937-07 |
| P8608 | Fatcat ID | release_5phh6qzuyzahxpvj4o7t34pami |
| P932 | PMC publication ID | 1951449 |
| P698 | PubMed publication ID | 17581983 |
| P5875 | ResearchGate publication ID | 6255260 |
| P50 | author | Charles M. Rice | Q22669757 |
| Brett Lindenbach | Q89673517 | ||
| François Penin | Q28322888 | ||
| Roland Montserret | Q28322890 | ||
| P2093 | author name string | Rudolf K F Beran | |
| Anna M Pyle | |||
| Béla M Prágai | |||
| P2860 | cites work | Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo | Q43035975 |
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| Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A. | Q43511551 | ||
| Determination of the helix and beta form of proteins in aqueous solution by circular dichroism. | Q52900971 | ||
| Structural biology of hepatitis C virus | Q56762917 | ||
| Los Alamos Hepatitis C Immunology Database | Q56880593 | ||
| Quantitative determination of helical propensities from trifluoroethanol titration curves | Q72266484 | ||
| Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity | Q24296473 | ||
| Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus | Q24336255 | ||
| Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage | Q24546084 | ||
| Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection | Q24546318 | ||
| Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication | Q24561987 | ||
| Kinetic and structural analyses of hepatitis C virus polyprotein processing | Q24648164 | ||
| Protein structure prediction servers at University College London | Q24812584 | ||
| Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B | Q27469363 | ||
| Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines | Q27469636 | ||
| The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding | Q27472668 | ||
| Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication | Q27472912 | ||
| Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase | Q27473147 | ||
| Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture | Q27473345 | ||
| Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins | Q27473469 | ||
| The Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A Hyperphosphorylation | Q27477609 | ||
| Replication of Hepatitis C Virus Subgenomes in Nonhepatic Epithelial and Mouse Hepatoma Cells | Q27478415 | ||
| Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase | Q27478443 | ||
| Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing | Q27478455 | ||
| A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro | Q27480287 | ||
| The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation | Q27480777 | ||
| The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins | Q27480848 | ||
| Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form | Q27484186 | ||
| Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins | Q27485988 | ||
| Substrate requirements of hepatitis C virus serine proteinase for intermolecular polypeptide cleavage in Escherichia coli | Q27486002 | ||
| Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing | Q27486004 | ||
| Hepatitis C virus polyprotein processing: kinetics and mutagenic analysis of serine proteinase-dependent cleavage | Q27486011 | ||
| Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase | Q27620480 | ||
| Involvement of electrostatic interactions in the mechanism of peptide folding induced by sodium dodecyl sulfate binding | Q27625501 | ||
| Solution structure and dynamics of Crh, the Bacillus subtilis catabolite repression HPr | Q27638591 | ||
| Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide | Q27733707 | ||
| Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR | Q27741016 | ||
| Efficient initiation of HCV RNA replication in cell culture | Q27860520 | ||
| The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data | Q27860592 | ||
| The Xplor-NIH NMR molecular structure determination package | Q27860805 | ||
| Complete replication of hepatitis C virus in cell culture | Q27860934 | ||
| Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase | Q27860943 | ||
| The PredictProtein server | Q29547578 | ||
| Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF | Q29547901 | ||
| Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease | Q29614208 | ||
| JPred: a consensus secondary structure prediction server | Q29614378 | ||
| PHD: predicting one-dimensional protein structure by profile-based neural networks | Q29614390 | ||
| Novel insights into hepatitis C virus replication and persistence | Q29620681 | ||
| The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein | Q30667774 | ||
| Trifluoroethanol and colleagues: cosolvents come of age. Recent studies with peptides and proteins. | Q33671691 | ||
| The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others | Q34397835 | ||
| Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells | Q35702021 | ||
| From structure to function: new insights into hepatitis C virus RNA replication | Q36366142 | ||
| The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently | Q36607807 | ||
| 'Random coil' 1H chemical shifts obtained as a function of temperature and trifluoroethanol concentration for the peptide series GGXGG. | Q36718622 | ||
| The 13C chemical shifts of amino acids in aqueous solution containing organic solvents: application to the secondary structure characterization of peptides in aqueous trifluoroethanol solution | Q36744961 | ||
| Viral evolution and interferon resistance of hepatitis C virus RNA replication in a cell culture model | Q37583537 | ||
| Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors | Q40196972 | ||
| Genetic interactions between hepatitis C virus replicons. | Q40214051 | ||
| Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis | Q40270295 | ||
| Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture | Q40273957 | ||
| Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain. | Q40458895 | ||
| Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. | Q40484115 | ||
| Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase | Q40594605 | ||
| Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A. | Q42045177 | ||
| Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome. | Q42596301 | ||
| Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus | Q42807763 | ||
| Identification of an immunodominant B cell epitope on the hepatitis C virus nonstructural region defined by human monoclonal antibodies | Q42807907 | ||
| Immune responses to the hepatitis C virus NS4A protein are profoundly influenced by the combination of the viral genotype and the host major histocompatibility complex | Q42985480 | ||
| Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus | Q42987114 | ||
| P433 | issue | 17 | |
| P921 | main subject | viral genome replication | Q3933202 |
| hepatitis C | Q154869 | ||
| Hepatitis C virus | Q708693 | ||
| P304 | page(s) | 8905-18 | |
| P577 | publication date | 2007-09-01 | |
| P1433 | published in | Journal of Virology | Q1251128 |
| P1476 | title | The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication | |
| P478 | volume | 81 |
| Q27487128 | A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication |
| Q27490546 | A Novel Class of meso-Tetrakis-Porphyrin Derivatives Exhibits Potent Activities against Hepatitis C Virus Genotype 1b Replicons In Vitro |
| Q34427768 | A cell culture adapted HCV JFH1 variant that increases viral titers and permits the production of high titer infectious chimeric reporter viruses |
| Q39668641 | A comparative analysis of the substrate permissiveness of HCV and GBV-B NS3/4A proteases reveals genetic evidence for an interaction with NS4B protein during genome replication |
| Q35578182 | A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication |
| Q34295420 | A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV) |
| Q36267476 | A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis |
| Q39158465 | ACH-806, an NS4A antagonist, inhibits hepatitis C virus replication by altering the composition of viral replication complexes |
| Q37335699 | Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor |
| Q56395782 | Adaptive mutation F772S-enhanced p7-NS4A cooperation facilitates the assembly and release of hepatitis C virus and is associated with lipid droplet enlargement |
| Q42904936 | Advances in research on HCV replication and virion formation |
| Q38727226 | Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production |
| Q92058889 | Analysis of methyltransferase (MTase) domain from Zika virus (ZIKV) |
| Q27485493 | Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level |
| Q37514366 | Cellular and molecular biology of HCV infection and hepatitis |
| Q24310514 | Cellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A protein |
| Q56484346 | Cloning and Expression of NS3 Gene of Pakistani Isolate Type 2 Dengue Virus |
| Q40051172 | Complete genome analysis of dengue virus type 3 isolated from the 2013 dengue outbreak in Yunnan, China |
| Q27486431 | Coordinated evolution of the hepatitis C virus |
| Q37201846 | Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems |
| Q27488216 | Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase |
| Q39728730 | Development of robust in vitro serine protease assay based on recombinant Pakistani HCV NS3-4A protease |
| Q27486248 | Effects of Mutagenic and Chain-Terminating Nucleotide Analogs on Enzymes Isolated from Hepatitis C Virus Strains of Various Genotypes |
| Q38289956 | Flavivirus reverse genetic systems, construction techniques and applications: a historical perspective |
| Q30857727 | Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus |
| Q36607822 | Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation |
| Q27488958 | Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C |
| Q27489514 | Hepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes |
| Q38086753 | Hepatitis C virus RNA replication |
| Q38294573 | Hepatitis C virus RNA replication and assembly: living on the fat of the land |
| Q37547774 | Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain. |
| Q28546101 | Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins |
| Q24317879 | Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein |
| Q37862375 | Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus |
| Q34043316 | Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses |
| Q30378119 | Phylogenetic and 2D/3D Analysis of HCV 1a NS4A Gene/Protein in Pakistani Isolates. |
| Q43040835 | Phylogenetic and structural analysis of HCV nonstructural protein 4A from Pakistani patients |
| Q37408926 | Post-translational modifications of hepatitis C viral proteins and their biological significance |
| Q115250790 | RNA Association, RNA Interference, and microRNA Pathways in Dengue Fever Virus-Host Interaction |
| Q30421625 | Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein |
| Q33878202 | Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action |
| Q39817292 | Structural and functional parameters of the flaviviral protease: a promising antiviral drug target |
| Q27487047 | Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex |
| Q26991855 | Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function |
| Q39712899 | TARGETING THE NS5A PROTEIN OF HCV: AN EMERGING OPTION. |
| Q34620091 | Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase |
| Q39145842 | The HepaRG cell line: a valuable in vitro tool for hepatitis virus infection studies |
| Q27488207 | The NS4A Protein of Hepatitis C Virus Promotes RNA-Coupled ATP Hydrolysis by the NS3 Helicase |
| Q42170036 | The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly |
| Q63246498 | The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein |
| Q21131379 | The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A |
| Q24658300 | The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery |
| Q40217373 | The role of noncoding regions of classical swine fever virus C-strain in its adaptation to the rabbit |
| Q43041225 | The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate |
| Q38584271 | Update on the Development of Anti-Viral Agents Against Hepatitis C. |
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