Viral suppression of the interferon system

scientific article published on 27 January 2007

Viral suppression of the interferon system is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.BIOCHI.2007.01.005
P698PubMed publication ID17336442

P50authorFriedemann WeberQ40182480
P2093author name stringOtto Haller
P2860cites workInhibition of the interferon-inducible protein kinase PKR by HCV E2 proteinQ22010192
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virusQ24311228
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusQ24336255
The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN.Q24527590
The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirusQ24533256
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machineryQ24534097
ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cellsQ24535541
Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 proteinQ24538727
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavageQ24546084
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoterQ24558779
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathwayQ24563231
Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityQ24599944
Inhibition of interferon signaling by dengue virusQ24630622
Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cellsQ27469379
Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal protease, NproQ27469610
The interferon antagonist NS2 protein of respiratory syncytial virus is an important virulence determinant for humansQ45420643
Sendai virus C protein physically associates with Stat1.Q45736579
Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virusQ45762580
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factorQ45772727
Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificityQ45785576
Reovirus sigma 3 protein: dsRNA binding and inhibition of RNA-activated protein kinaseQ74585528
Characterization of viral double-stranded RNA-binding proteinsQ77293294
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcriptionQ39960501
Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulationQ40012127
Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative miceQ40163331
Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonistsQ40208162
The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activationQ40213877
mda-5, but not RIG-I, is a common target for paramyxovirus V proteins.Q40218590
Influenza virus evades innate and adaptive immunity via the NS1 proteinQ40267847
Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1.Q40272095
Inhibition of interferon signaling by the Kaposi's sarcoma-associated herpesvirus full-length viral interferon regulatory factor 2 protein.Q40311533
Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2.Q40311646
Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA.Q40319046
Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway.Q40336119
Role of double-stranded RNA and Npro of classical swine fever virus in the activation of monocyte-derived dendritic cellsQ40375175
N(pro) of classical swine fever virus is an antagonist of double-stranded RNA-mediated apoptosis and IFN-alpha/beta inductionQ40393486
Identification of the rabies virus alpha/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3.Q40416432
Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonistQ40554311
The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteinsQ40572718
Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 stimulates the transcriptional activity of cellular IRF-3 and IRF-7.Q40608568
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complexQ40666097
All four Sendai Virus C proteins bind Stat1, but only the larger forms also induce its mono-ubiquitination and degradationQ40729242
The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.Q40808240
Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectivelyQ40883579
Unique properties of a second human herpesvirus 8-encoded interferon regulatory factor (vIRF-2).Q40961025
Vaccinia virus-encoded cytokine receptor binds and neutralizes chicken interferon-gammaQ41012375
Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathwaysQ41843640
Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virusQ41847342
Double-stranded RNA binding by human cytomegalovirus pTRS1.Q42147481
A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responsesQ42215415
Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA virusesQ42425012
Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathwayQ42425053
Inhibition of host RNA polymerase II-dependent transcription by vesicular stomatitis virus results from inactivation of TFIID.Q42464743
Defective translational control facilitates vesicular stomatitis virus oncolysisQ42831942
Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L.Q44946042
Double-stranded RNA binding by a heterodimeric complex of murine cytomegalovirus m142 and m143 proteinsQ38761545
Double-stranded RNA binding of influenza B virus nonstructural NS1 protein inhibits protein kinase R but is not essential to antagonize production of alpha/beta interferonQ39320757
Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factorsQ39593162
The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradationQ39596942
Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSsQ39601913
Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulationQ39685810
Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteinsQ39699288
Regulation of the double-stranded RNA-dependent protein kinase PKR by RNAs encoded by a repeated sequence in the Epstein-Barr virus genomeQ39718117
The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signalingQ39732576
Degradation of STAT1 and STAT2 by the V proteins of simian virus 5 and human parainfluenza virus type 2, respectively: consequences for virus replication in the presence of alpha/beta and gamma interferonsQ39748096
STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signalingQ39752565
STAT protein interference and suppression of cytokine signal transduction by measles virus V proteinQ39787663
Role of alpha/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteinsQ39789324
Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesisQ27469667
Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathwayQ27469729
Inhibition of the protein kinase PKR by the internal ribosome entry site of hepatitis C virus genomic RNAQ27472970
The NPro Product of Bovine Viral Diarrhea Virus Inhibits DNA Binding by Interferon Regulatory Factor 3 and Targets It for Proteasomal DegradationQ27477650
Classical Swine Fever Virus Interferes with Cellular Antiviral Defense: Evidence for a Novel Function of NproQ27477664
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphatesQ27861007
The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivoQ27863699
5'-Triphosphate RNA is the ligand for RIG-IQ28131726
Virus interference. I. The interferonQ28181608
Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene productQ28244407
RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cellsQ28609293
Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.Q28609759
Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNASQ28609773
A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in miceQ28609778
Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transportQ28609810
RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cellsQ28610868
Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient SystemsQ29039793
Stats: transcriptional control and biological impactQ29547776
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasuresQ29618978
Replication of modified vaccinia virus Ankara in primary chicken embryo fibroblasts requires expression of the interferon resistance gene E3L.Q33187731
TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.Q33198557
Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzeesQ33605207
Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300.Q33649357
Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 proteinQ33659093
Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.Q33781480
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factorQ33784902
Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation of intracerebral injection in nonhuman primates.Q33816579
Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 proteinQ33827148
The leader protein of Theiler's virus inhibits immediate-early alpha/beta interferon productionQ33853304
Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinaseQ33886447
Influenza A and B viruses expressing altered NS1 proteins: A vaccine approachQ33895154
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virusQ33908950
The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2Q33930433
Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA virusesQ33932047
Cytopathogenesis and inhibition of host gene expression by RNA virusesQ34010277
Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes: outcome with influenza A virus is uniqueQ34099139
Protection from interferon-induced apoptosis by Epstein-Barr virus small RNAs is not mediated by inhibition of PKR.Q34142897
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agentsQ34273164
Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomasQ34297434
Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.Q34337534
Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1Q34348314
The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune responseQ34353443
Reovirus therapy of tumors with activated Ras pathwayQ34479740
Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccineQ34561944
The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathwayQ34598589
Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell linesQ34648125
Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signalingQ34648134
Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulationQ34648461
Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replicationQ34717075
Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon.Q35000433
Rinderpest virus blocks type I and type II interferon action: role of structural and nonstructural proteinsQ35023714
Viruses and the type I interferon antiviral system: induction and evasionQ35027514
The pathogenic NY-1 hantavirus G1 cytoplasmic tail inhibits RIG-I- and TBK-1-directed interferon responsesQ35101310
Murine cytomegalovirus m142 and m143 are both required to block protein kinase R-mediated shutdown of protein synthesisQ35101535
The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.Q35105093
Neutralizing innate host defenses to control viral translation in HSV-1 infected cellsQ35613824
Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificityQ35843985
The vesicular stomatitis virus matrix protein inhibits transcription from the human beta interferon promoterQ35874889
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-Q35964369
Inverse interference: how viruses fight the interferon systemQ36020589
Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA virusesQ36096753
The interferon response circuit: induction and suppression by pathogenic virusesQ36346824
Type 1 interferons and the virus-host relationship: a lesson in détente .Q36475884
Inhibition of PKR by RNA and DNA virusesQ36480640
Adenovirus virus-associated RNA and translation controlQ36820396
A cytomegalovirus inhibitor of gamma interferon signaling controls immunoproteasome inductionQ36960167
Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sitesQ37094247
Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes.Q37596474
Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription.Q38341017
P433issue6-7
P407language of work or nameEnglishQ1860
P304page(s)836-842
P577publication date2007-01-27
P1433published inBiochimieQ2904035
P1476titleViral suppression of the interferon system
P478volume89

Reverse relations

cites work (P2860)
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