Influenza virus evades innate and adaptive immunity via the NS1 protein

scientific article published on July 2006

Influenza virus evades innate and adaptive immunity via the NS1 protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02381-05
P8608Fatcat IDrelease_mzsw4sprsza6ja32o25trjlph4
P932PMC publication ID1488970
P698PubMed publication ID16775317

P50authorAdolfo García-SastreQ4684232
Stuart C SealfonQ58051864
Ana Fernández-SesmaQ37368173
P2093author name stringThomas M Moran
Tony Yuen
Svetlana Marukian
Man-Seong Park
Barbara J Ebersole
Dorothy Kaminski
P2860cites workGene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cellsQ24307725
Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cellsQ27469379
Dendritic cells and the control of immunityQ27860918
IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L proteinQ28140837
Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.Q28609759
A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in miceQ28609778
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAsQ28609836
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immatureQ71656310
IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cellsQ74145377
Dendritic cell development and survival require distinct NF-kappaB subunitsQ77704364
Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18Q81158144
Viral mechanisms of immune evasionQ93939877
Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient SystemsQ29039793
Immunobiology of dendritic cellsQ29547465
Interleukin-12 and the regulation of innate resistance and adaptive immunityQ29614602
Dendritic cells: specialized and regulated antigen processing machinesQ29617085
Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infectionQ30465682
Dendritic cells maximize the memory CD8 T cell response to infectionQ33801974
Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 proteinQ33810694
Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigsQ33843120
Attenuation of equine influenza viruses through truncations of the NS1 proteinQ33843410
Influenza A and B viruses expressing altered NS1 proteins: A vaccine approachQ33895154
Multiple control of interleukin-8 gene expressionQ34648084
Mechanisms of inhibition of the host interferon alpha/beta-mediated antiviral responses by virusesQ34669736
Influenza vaccines: present and futureQ34717840
Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectorsQ35848582
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infectionQ35978569
The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulationQ36402640
Adjuvant activities of novel cytokines, interleukin-23 (IL-23) and IL-27, for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice.Q37349027
Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes.Q37596474
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.Q38973017
Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cellsQ39579384
Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferonQ39593618
Accuracy and calibration of commercial oligonucleotide and custom cDNA microarraysQ39607930
The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factorsQ39685168
Newcastle disease virus V protein is a determinant of host range restrictionQ39864222
A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication in vitro.Q39875306
Molecular mechanisms of variation in influenza virusesQ40102702
Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory CortexQ40629393
Origin, maturation and antigen presenting function of dendritic cells.Q40906220
Th2 responses to inactivated influenza virus can Be converted to Th1 responses and facilitate recovery from heterosubtypic virus infectionQ40937084
Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virusQ42723106
Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathwaysQ45537161
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factorQ45772727
TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA virusesQ47892185
Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins.Q51349178
Distinct patterns and kinetics of chemokine production regulate dendritic cell function.Q54093362
Type I Interferon Induction Pathway, but Not Released Interferon, Participates in the Maturation of Dendritic Cells Induced by Negative‐Strand RNA VirusesQ56877437
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)6295-6304
P577publication date2006-07-01
P1433published inJournal of VirologyQ1251128
P1476titleInfluenza virus evades innate and adaptive immunity via the NS1 protein
P478volume80

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