KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells

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KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.177.6.1651
P932PMC publication ID2191052
P698PubMed publication ID8496683
P5875ResearchGate publication ID14701999

P50authorPatrick A. BaeuerleQ113868
Lea EisenbachQ59696159
P2093author name stringD Plaksin
P2860cites workI kappa B: a specific inhibitor of the NF-kappa B transcription factorQ24296774
Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65Q24309237
Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleusQ24337591
The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptidesQ24339477
NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunitQ24561421
The p65 subunit is responsible for the strong transcription activating potential of NF-kappa BQ24564667
Down-regulation of class I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma linesQ24605501
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibitionQ28155838
The inducible transcription activator NF-kappa B: regulation by distinct protein subunitsQ28274350
H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response elementQ28508930
Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expressionQ28587941
Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa BQ28645847
Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsalQ29618196
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene productQ29618249
Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activityQ29618284
Molecular cloning of an enhancer binding protein: isolation by screening of an expression library with a recognition site DNAQ29620537
Reversal of the metastatic phenotype in Lewis lung carcinoma cells after transfection with syngeneic H-2Kb geneQ33582592
TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factorsQ33609443
Purification of KBF1, a common factor binding to both H-2 and beta 2-microglobulin enhancersQ33929799
The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50Q33938198
DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptideQ34088506
Selective changes in expression of HLA class I polymorphic determinants in human solid tumorsQ34301621
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunitQ34357628
A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genesQ34616824
Regulation of murine class I genes by interferons is controlled by regions located both 5' and 3' to the transcription initiation siteQ34624493
Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cellsQ35234796
Many transcription factors interact synergistically with steroid receptorsQ67985336
Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomasQ68032800
Transcriptional regulation of the HIV-1 promoter by NF-kappa B in vitroQ68111216
The c-fos proto-oncogene in murine 3LL carcinoma clones controls the expression of MHC genesQ69026379
Regulation of HLA class I transcription in T cellsQ69787697
Functional analysis of the mouse H-2Kb gene promoter in embryonal carcinoma cellsQ70090193
MHC imbalance and metastatic spread in Lewis lung carcinoma clonesQ71765267
Presentation of antigenic peptides by MHC class I moleculesQ75292704
The nucleotide sequence of the rat cytoplasmic β–actin geneQ35672782
NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeatsQ35875812
Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancerQ36350013
Developmental and tissue-specific expression of nuclear proteins that bind the regulatory element of the major histocompatibility complex class I gene.Q36356077
Functional expression of a mouse H-2Kb gene isolated from non-expressing teratocarcinoma cellsQ36624910
Antigen presentation: structural themes and functional variationsQ36659704
Retinoic acid-dependent transactivation of major histocompatibility complex class I promoters by the nuclear hormone receptor H-2RIIBP in undifferentiated embryonal carcinoma cellsQ36810921
Binding of a nuclear factor to a regulatory sequence in the promoter of the mouse H-2Kb class I major histocompatibility geneQ36833546
Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expressionQ36957042
Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cellsQ37347001
Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoterQ37485004
NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytesQ38328214
Activity of the kappa B enhancer of the interleukin-2 receptor alpha chain in somatic cell hybrids is accompanied by the nuclear localization of NF-kappa BQ38332626
Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B.Q38336043
The role of the p50 and p65 subunits of NF-kappa B in the recognition of cognate sequencesQ38336346
DNA binding of regulatory factors interacting with MHC-class-I gene enhancer correlates with MHC-class-I transcriptional level in class-I-defective cell linesQ38337374
A transcription factor interacting with the class I gene enhancer is inactive in tumorigenic cell lines which suppress major histocompatibility complex class I genesQ38339859
Major histocompatibility complex class I genes in murine fibrosarcoma IC9 are down regulated at the level of the chromatin structureQ40646985
The SV40 TC-II(kappa B) and the related H-2Kb enhansons exhibit different cell type specific and inducible proto-enhancer activities, but the SV40 core sequence and the AP-2 binding site have no enhanson propertiesQ40820614
The SV40 TC-II(kappa B) enhanson binds ubiquitous and cell type specifically inducible nuclear proteins from lymphoid and non-lymphoid cell linesQ40820623
Identification of sequences responsible for positive and negative regulation by E1A in the promoter of H-2Kbm1 class I MHC geneQ41200298
DNA sequence analysis of the C3H H-2Kk and H-2Dk loci. Evolutionary relationships to H-2 genes from four other mouse strainsQ41303549
The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulationQ41514176
Regulation of gene expression by interferons: control of H-2 promoter responsesQ42098641
Absence of human leukocyte antigen molecules in skin tumors and some cutaneous appendages: Evidence using monoclonal antibodiesQ42449305
Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.Q42799960
Differential expression of H-2 gene products in tumour cells in associated with their metastatogenic propertiesQ42802345
The differential expression of H-2K versus H-2D antigens, distinguishing high-metastatic from low-metastatic clones, is correlated with the immunogenic properties of the tumor cells.Q42822926
Loss of polymorphic A and B locus HLA antigens in colon carcinomaQ43050288
HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinomasQ43050854
Selective loss of HLA-A or HLA-B antigen expression in colon carcinomaQ43489693
c-fos transfection of 3LL tumor cells turns on MHC gene expression and consequently reduces their metastatic competence.Q44189446
Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cellsQ44899739
H-2-restricted cytolytic T cells specific for HLA can recognize a synthetic HLA peptideQ45084111
A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.Q45142085
I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B familyQ46153930
Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines.Q52832672
Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa BQ54270780
Loss of expression of transplantation antigens encoded by the H-2K locus on Lewis lung carcinoma cells and its relevance to the tumor's metastatic propertiesQ54495181
Resistance to cell-mediated cytotoxicity is correlated with reduction of H-2K gene products in AKR leukemia.Q54524583
SELECTIVE LOSS OF HLA-A,B,C LOCUS PRODUCTS IN COLORECTAL ADENOCARCINOMAQ57337256
Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunityQ57541531
Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H–2 geneQ59081319
H-2Db gene transfer into highly metastatic D122 cells results in tumor rejection in allogeneic recipients, but does not affect metastasis in syngeneic recipients. Implications for mechanisms of allorejectionQ67577416
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)1651-1662
P577publication date1993-06-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleKBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells
P478volume177

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cites work (P2860)
Q40246228(DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit
Q40761786A T cell-specific enhancer of the human CD40 ligand gene
Q38355620A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cells
Q39640071Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis
Q41829978Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention
Q39002185Alterations in NF-kappaB and RBP-Jkappa by arenavirus infection of macrophages in vitro and in vivo
Q35834615An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis
Q37398298Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity
Q42260610Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter
Q40018450Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo
Q36225743EHMT1 protein binds to nuclear factor-κB p50 and represses gene expression
Q36591837Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-kappaB
Q40370035Enhancement of NF-kappaB activity by resveratrol in cytokine-exposed mesangial cells.
Q37391100Enhancing the recognition of tumour associated antigens.
Q36556942Evidence for the involvement of a nuclear NF-kappa B inhibitor in global down-regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells
Q74460729Excretory/secretory products from plerocercoids of Spirometra erinaceieuropaei suppress the TNF-alpha gene expression by reducing phosphorylation of ERK1/2 and p38 MAPK in macrophages
Q40551597From Aristotle, through Spemann, to tumor immunology: a personal experience.
Q39540152Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.
Q58610858Gain-of-function mutation causes human combined immune deficiency
Q40185662Generation of inhibitory NFkappaB complexes and phosphorylated cAMP response element-binding protein correlates with the anti-inflammatory activity of complement protein C1q in human monocytes
Q38311419HLA class I antigen downregulation by interleukin (IL)-10 is predominantly governed by NK-kappaB in the short term and by TAP1+2 in the long term.
Q40023974Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding
Q38363101IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.
Q35115637Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses
Q36566451Identification of the rel family members required for virus induction of the human beta interferon gene
Q42481352Increased expression of p50-NF-kappaB and constitutive activation of NF-kappaB transcription factors during mouse skin carcinogenesis
Q39822031Lipoarabinomannans derived from different strains of Mycobacterium tuberculosis differentially stimulate the activation of NF-kappa B and KBF1 in murine macrophages.
Q40476139Lipopolysaccharide induces 5-lipoxygenase-activating protein gene expression in THP-1 cells via a NF-kappaB and C/EBP-mediated mechanism.
Q29547864Missing pieces in the NF-kappaB puzzle
Q28397259Mitochondria and reactive oxygen species: physiology and pathophysiology
Q34998247Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes
Q28575104Myotrophin/V-1 does not act as an extracellular signal to induce myocyte hypertrophy
Q28215631Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers
Q37377834NF-kappaB mediates mitogen-activated protein kinase pathway-dependent iNOS expression in human melanoma
Q41767515Nuclear Factor κB and Adenosine Receptors: Biochemical and Behavioral Profiling
Q52311688Nuclear Factor-kappaB in Autoimmunity: Man and Mouse.
Q38358818Nuclear factor-kappaB binds to the Epstein-Barr Virus LMP1 promoter and upregulates its expression
Q35741937Nuclear factor-kappaB modulation as a therapeutic approach in hematologic malignancies
Q43681634Nuclear factor-kappaB p50 limits inflammation and prevents lung injury during Escherichia coli pneumonia
Q40838191Oscillating fluid flow inhibits TNF-alpha -induced NF-kappa B activation via an Ikappa B kinase pathway in osteoblast-like UMR106 cells
Q28371975Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA
Q39119033Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKα.
Q39444910Reduced phosphorylation of p50 is responsible for diminished NF-kappaB binding to the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells
Q21296830Regulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages
Q24296921Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1
Q40160616Regulation of porcine classical and nonclassical MHC class I expression
Q34465473Ribosomal proteins: functions beyond the ribosome
Q40912575Role of p52 (NF-kappaB2) in LPS tolerance in a human B cell line
Q21090517Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism
Q33814017Sequences between the enhancer and promoter in the long terminal repeat affect murine leukemia virus pathogenicity and replication in the thymus
Q27640073Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation
Q91704213Stable intronic sequence RNAs (sisRNAs) are selected regions in introns with distinct properties
Q42198449TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent
Q40729355Tamoxifen enhancement of TNF-alpha induced MnSOD expression: modulation of NF-kappaB dimerization
Q33655868Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling
Q35194794The E3 ligase c-Cbl regulates dendritic cell activation
Q24293229The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
Q39587742The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50

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