Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction

scientific article published on 31 March 2021

Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/V13040589
P932PMC publication ID8066714
P698PubMed publication ID33807175

P2093author name stringStephen Goodbourn
Miren Iturriza-Gomara
Julian Seago
Ben Jackson
Mark Boyce
Neil Blake
Kay Childs
Gennaro Iaconis
P2860cites workA paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infectionQ37612580
NSP1 of human rotaviruses commonly inhibits NF-κB signalling by inducing β-TrCP degradationQ38907450
Rotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-α.Q38996491
Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1.Q39684543
IRF3 inhibition by rotavirus NSP1 is host cell and virus strain dependent but independent of NSP1 proteasomal degradation.Q39816481
The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3.Q40065557
Rotavirus NSP1 Requires Casein Kinase II-Mediated Phosphorylation for Hijacking of Cullin-RING LigasesQ40066025
Regulation of porcine classical and nonclassical MHC class I expressionQ40160616
The MCV MC159 protein inhibits late, but not early, events of TNF-α-induced NF-κB activationQ40393980
Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elementsQ41094092
Role of interferon in homologous and heterologous rotavirus infection in the intestines and extraintestinal organs of suckling miceQ41339221
Permissive replication of homologous murine rotavirus in the mouse intestine is primarily regulated by VP4 and NSP1.Q43079549
The beta-interferon promoter responds to priming through multiple independent regulatory elements.Q43542284
Type III Interferon Restriction by Porcine Epidemic Diarrhea Virus and the Role of Viral Protein nsp1 in IRF1 SignalingQ44877460
Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.Q50335887
Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonismQ21090517
Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene IQ24299094
Rotavirus NSP1 inhibits interferon induced non-canonical NFκB activation by interacting with TNF receptor associated factor 2Q24311932
RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epitheliumQ24321688
MAVS protein is attenuated by rotavirus nonstructural protein 1Q24339399
Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3Q24555785
Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7Q24683021
RotavirusesQ26996393
Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infectionsQ27320523
Classical Swine Fever Virus Npro Interacts with Interferon Regulatory Factor 3 and Induces Its Proteasomal DegradationQ27478373
The Rotavirus Interferon Antagonist NSP1: Many Targets, Many QuestionsQ28067379
IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genesQ28245089
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activationQ28256216
Zinc-binding domain of rotavirus NSP1 is required for proteasome-dependent degradation of IRF3 and autoregulatory NSP1 stabilityQ28284962
IFN-lambda determines the intestinal epithelial antiviral host defenseQ28508039
Identification of novel co-repressor molecules for Interferon Regulatory Factor-2Q28589914
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasuresQ29615028
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosomeQ29616850
Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoterQ33562993
Diverse intracellular pathogens activate type III interferon expression from peroxisomesQ33933986
Classical swine fever virus N(pro) limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7.Q33934870
Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strainsQ34742076
Putative E3 ubiquitin ligase of human rotavirus inhibits NF-κB activation by using molecular mimicry to target β-TrCP.Q35072342
The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3.Q35076535
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C VirusQ35847364
Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1.Q36710258
Cultivation and characterization of three strains of murine rotavirusQ36857827
Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.Q37021757
Rotavirus NSP1 mediates degradation of interferon regulatory factors through targeting of the dimerization domainQ37123575
Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB.Q37192229
Rotavirus NSP1 protein inhibits interferon-mediated STAT1 activationQ37547591
Viral Infections Activate Types I and III Interferon Genes through a Common MechanismQ56880076
Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA virusesQ63248455
Differential Regulation of Type I and Type III Interferon SignalingQ64065850
IRF1 Maintains Optimal Constitutive Expression of Antiviral Genes and Regulates the Early Antiviral Response.Q64971795
Interferon-λ orchestrates innate and adaptive mucosal immune responsesQ92761688
Real-world effectiveness of rotavirus vaccines, 2006-19: a literature review and meta-analysisQ98625964
The TLR3/IRF1/Type III IFN Axis Facilitates Antiviral Responses against Enterovirus Infections in the IntestineQ114457708
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usessimian rhesus rotavirusQ112242067
Bovine rotavirus strain UKQ113433734
porcine rotavirusQ113469026
human rotavirusQ113531739
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectRotavirusQ164778
NF-κBQ411114
modulation by virus of host processQ14818042
Rotavirus non-structural protein 1Q24724262
Type I interferonQ93236923
P304page(s)589
P577publication date2021-03-31
P1433published inVirusesQ7935305
P1476titleRotavirus NSP1 Inhibits Type I and Type III Interferon Induction
P478volume13

Reverse relations

Q114370871Rotavirus Interactions With Host Intestinal Epithelial Cellscites workP2860

Search more.