Abstract is: NSP1 (NS53), the product of rotavirus gene 5, is a nonstructural RNA-binding protein that contains a cysteine-rich region and is a component of early replication intermediates. RNA-folding predictions suggest that this region of the NSP1 mRNA can interact with itself, producing a stem-loop structure similar to that found near the 5'-terminus of the NSP1 mRNA. The carboxyl-half of the rotavirus nonstructural protein NSP1 is not required for virus replication. NSP1 could play a role in host range restriction. The cysteine-rich region of NSP1 is not considered essential for genome segment reassortment with heterologous virus. NSP1 interacts with IRF3 in the infected cell. NSP1 is an antagonist of the IFN-signaling pathway. Interferon regulatory factor 3 (IRF3) is a key transcription factor involved in the induction of interferon (IFN) in response to viral infection. NSP1 binds to and targets IRF3 for proteasome degradation early post-infection. IRF3 degradation is dependent on the presence of NSP1 and the integrity of the N-terminal zinc-binding domain, coupled with the regulated stability of IRF3 and NSP1 by the proteasome, collectively support the hypothesis that NSP1 is an E3 ubiquitin ligase. NSP1 could mediates the degradation of IRF3, IRF5, and IRF7 by recognizing a common element of IRF proteins, thereby allowing NSP1 to act as a broad-spectrum antagonist of IRF function. NSP1 also inhibits activation of NFkappaB NSP1 inhibits cellular apoptosis by directly interacting p85 subunit of PI3K and thus activating PI3K/Akt survival pathway during early stages of rotavirus infection.
| P646 | Freebase ID | /m/03crl57 |
| P2926 | InterPro ID | IPR002148 |
| P6366 | Microsoft Academic ID | 2780697327 |
| P680 | molecular function | RNA binding | Q14330639 |
| Q92690126 | Biphasic regulation of RNA interference during rotavirus infection by modulation of Argonaute2 |
| Q28554481 | Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex |
| Q36634428 | Deletion mapping of the rotavirus metalloprotein NS53 (NSP1): the conserved cysteine-rich region is essential for virus-specific RNA binding |
| Q43406052 | Determinants of rotavirus host range restriction--a heterologous bovine NSP1 gene does not affect replication kinetics in the pig. |
| Q34742076 | Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains |
| Q33850456 | Effect of intragenic rearrangement and changes in the 3' consensus sequence on NSP1 expression and rotavirus replication |
| Q47930114 | Functional analysis of the heterologous NSP1 genes in the genetic background of simian rotavirus SA11. |
| Q39816481 | IRF3 inhibition by rotavirus NSP1 is host cell and virus strain dependent but independent of NSP1 proteasomal degradation. |
| Q47916655 | In vivo interactions among rotavirus nonstructural proteins. |
| Q39684543 | Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1. |
| Q24339399 | MAVS protein is attenuated by rotavirus nonstructural protein 1 |
| Q28280924 | Molecular mechanism behind rotavirus NSP1-mediated PI3 kinase activation: interaction between NSP1 and the p85 subunit of PI3 kinase |
| Q38907450 | NSP1 of human rotaviruses commonly inhibits NF-κB signalling by inducing β-TrCP degradation |
| Q43079549 | Permissive replication of homologous murine rotavirus in the mouse intestine is primarily regulated by VP4 and NSP1. |
| Q40223856 | Post-translational regulation of rotavirus protein NSP1 expression in mammalian cells. |
| Q38331589 | Regulation of gene expression by the NSP1 and NSP3 non-structural proteins of rotavirus |
| Q41998682 | Roles of VP4 and NSP1 in determining the distinctive replication capacities of simian rotavirus RRV and bovine rotavirus UK in the mouse biliary tract |
| Q114370943 | Rotavirus Induces Epithelial-Mesenchymal Transition Markers by Transcriptional Suppression of miRNA-29b |
| Q37002502 | Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases |
| Q114371217 | Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction |
| Q40066025 | Rotavirus NSP1 Requires Casein Kinase II-Mediated Phosphorylation for Hijacking of Cullin-RING Ligases |
| Q21090517 | Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism |
| Q24683021 | Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7 |
| Q24311932 | Rotavirus NSP1 inhibits interferon induced non-canonical NFκB activation by interacting with TNF receptor associated factor 2 |
| Q114370948 | Rotavirus NSP1 localizes in the nucleus to disrupt PML nuclear bodies during infection |
| Q37123575 | Rotavirus NSP1 mediates degradation of interferon regulatory factors through targeting of the dimerization domain |
| Q37547591 | Rotavirus NSP1 protein inhibits interferon-mediated STAT1 activation |
| Q24299094 | Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I |
| Q24555785 | Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3 |
| Q24610030 | Rotavirus nonstructural protein 1 suppresses virus-induced cellular apoptosis to facilitate viral growth by activating the cell survival pathways during early stages of infection |
| Q35122641 | Rotavirus replication: plus-sense templates for double-stranded RNA synthesis are made in viroplasms |
| Q24338301 | Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53 |
| Q37083338 | Silencing the alarms: Innate immune antagonism by rotavirus NSP1 and VP3 |
| Q41335189 | Structure and function of rotavirus NSP1. |
| Q34298633 | Structure and function of the rotavirus RNA-binding proteins. |
| Q33908930 | Study on the ubiquitin ligase activity of rotavirus NSP1 protein |
| Q28067379 | The Rotavirus Interferon Antagonist NSP1: Many Targets, Many Questions |
| Q28258866 | The carboxyl-half of the rotavirus nonstructural protein NS53 (NSP1) is not required for virus replication |
| Q40673569 | Translational regulation of rotavirus gene expression |
| Q28284962 | Zinc-binding domain of rotavirus NSP1 is required for proteasome-dependent degradation of IRF3 and autoregulatory NSP1 stability |
| NSP1 (rotavirus) | wikipedia |
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