A Single Amino Acid Substitution in the West Nile Virus Nonstructural Protein NS2A Disables Its Ability To Inhibit Alpha/Beta Interferon Induction and Attenuates Virus Virulence in Mice

scientific article

A Single Amino Acid Substitution in the West Nile Virus Nonstructural Protein NS2A Disables Its Ability To Inhibit Alpha/Beta Interferon Induction and Attenuates Virus Virulence in Mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.80.5.2396-2404.2006
P3181OpenCitations bibliographic resource ID3347508
P932PMC publication ID1395377
P698PubMed publication ID16474146
P5875ResearchGate publication ID7302835

P50authorAlexander A. KhromykhQ37368917
P2093author name stringRoy A Hall
Wen Jun Liu
Mario Lobigs
David C Clark
Xiang Ju Wang
P2860cites workDengue virus inhibits alpha interferon signaling by reducing STAT2 expressionQ24522443
Blocking of the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infectionQ24562957
Inhibition of interferon signaling by dengue virusQ24630622
Differential virulence of West Nile strains for American crowsQ24817166
Flavivirus Activates Phosphatidylinositol 3-Kinase Signaling To Block Caspase-Dependent Apoptotic Cell Death at the Early Stage of Virus InfectionQ27469840
Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replicationQ27470019
Inhibition of Transcription and Translation in Sindbis Virus-Infected CellsQ27470247
Infectious cDNA clone of the epidemic west nile virus from New York CityQ27472878
Molecular and Functional Analyses of Kunjin Virus Infectious cDNA Clones Demonstrate the Essential Roles for NS2A in Virus Assembly and for a Nonconservative Residue in NS3 in RNA ReplicationQ27477562
Subgenomic replicons of the flavivirus Kunjin: construction and applicationsQ27480783
DNA vaccine coding for the full-length infectious Kunjin virus RNA protects mice against the New York strain of West Nile virusQ27480946
Comparison of the effects of Sindbis virus and Sindbis virus replicons on host cell protein synthesis and cytopathogenicity in BHK cellsQ27485958
Viruses and interferon: a fight for supremacyQ28220397
A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in miceQ28609778
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasuresQ29618978
Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteinsQ29620712
Viruses and interferonsQ29620788
West Nile Virus Transmission in Resident Birds, Dominican RepublicQ33194871
West Nile virus inhibits the signal transduction pathway of alpha interferonQ33718537
Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigsQ33843120
Attenuation of equine influenza viruses through truncations of the NS1 proteinQ33843410
Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infectionQ34355773
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signalingQ34361655
The ecology and epidemiology of Kunjin virusQ34705765
The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathwayQ35122610
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptorsQ35844406
Inverse interference: how viruses fight the interferon systemQ36020589
Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses--and viruses counteract IFN actionQ36080993
Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA virusesQ36096753
Viruses know it all: new insights into IFN networksQ36142963
Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less criticalQ36510607
Analysis of adaptive mutations in Kunjin virus replicon RNA reveals a novel role for the flavivirus nonstructural protein NS2A in inhibition of beta interferon promoter-driven transcriptionQ37596892
Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells.Q39550411
Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cellsQ39752893
Studies on avian infectious bronchitis virus (IBV). III. Interferon induction by and sensitivity to interferon of IBV.Q40272135
Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.Q40623650
Murray Valley encephalitis virus field strains from Australia and Papua New Guinea: studies on the sequence of the major envelope protein gene and virulence for miceQ40785472
Virus spread, tissue inflammation and antiviral response in brains of flavivirus susceptible and resistant mice acutely infected with Murray Valley encephalitis virus.Q42983533
Loss of dimerisation of the nonstructural protein NS1 of Kunjin virus delays viral replication and reduces virulence in mice, but still allows secretion of NS1.Q42995762
Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirusQ43049528
Early expression of IFN-alpha/beta and iNOS in the brains of Venezuelan equine encephalitis virus-infected miceQ45743909
P433issue5
P921main subjectvirusQ808
West Nile virusQ158856
virulenceQ1460232
P304page(s)2396-404
P577publication date2006-03-01
P1433published inJournal of VirologyQ1251128
P1476titleA Single Amino Acid Substitution in the West Nile Virus Nonstructural Protein NS2A Disables Its Ability To Inhibit Alpha/Beta Interferon Induction and Attenuates Virus Virulence in Mice
P478volume80

Reverse relations

cites work (P2860)
Q38836534A Brief Review of West Nile Virus Biology
Q27480366A Combination of Naturally Occurring Mutations in North American West Nile Virus Nonstructural Protein Genes and in the 3' Untranslated Region Alters Virus Phenotype
Q22337381A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity
Q42983982A Kunjin replicon vector encoding granulocyte macrophage colony-stimulating factor for intra-tumoral gene therapy
Q27321020A Novel Synthetic TLR-4 Agonist Adjuvant Increases the Protective Response to a Clinical-Stage West Nile Virus Vaccine Antigen in Multiple Formulations
Q35641199A Single Amino Acid Substitution in the NS2A Protein of Japanese Encephalitis Virus Affects Virus Propagation In Vitro but Not In Vivo
Q35488765A basic cluster in the N terminus of yellow fever virus NS2A contributes to infectious particle production
Q33602692A critical determinant of neurological disease associated with highly pathogenic tick-borne flavivirus in mice
Q27481037A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis
Q92289508A natural polymorphism in Zika virus NS2A protein responsible of virulence in mice
Q33708559Abrogation of TLR3 inhibition by discrete amino acid changes in the C-terminal half of the West Nile virus NS1 protein
Q62485332Advances in Zika Virus⁻Host Cell Interaction: Current Knowledge and Future Perspectives
Q57296688An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo
Q38866173An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection
Q39347222Antagonism of type I interferon by flaviviruses
Q90131024Azithromycin Protects against Zika virus Infection by Upregulating virus-induced Type I and III Interferon Responses
Q89790279Binding of Duck Tembusu virus nonstructural protein 2A to duSTING disrupts the induction of its signal transduction cascade to inhibit IFN-β induction
Q45325120Biological and phylogenetic characteristics of West African lineages of West Nile virus
Q36276476Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A.
Q27480936Cell-Specific IRF-3 Responses Protect against West Nile Virus Infection by Interferon-Dependent and -Independent Mechanisms
Q36287746Cell-intrinsic innate immune control of West Nile virus infection
Q36736579Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication.
Q27485096Characterization of a small plaque variant of West Nile virus isolated in New York in 2000
Q34046030Chikungunya virus arthritis in adult wild-type mice
Q35220195Clinical outcome and genetic differences within a monophyletic Dengue virus type 2 population
Q23302003Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic
Q35075777Comparison of the neuropathology induced by two West Nile virus strains
Q37734118Construction and characterisation of a complete reverse genetics system of dengue virus type 3.
Q40349415Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS5.
Q34788758Current trends in West Nile virus vaccine development
Q37547492Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response
Q35620170Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant
Q40225767Dengue virus subgenomic RNA induces apoptosis through the Bcl-2-mediated PI3k/Akt signaling pathway
Q40374575Development and characterization of non-glycosylated E and NS1 mutant viruses as a potential candidate vaccine for West Nile virus
Q38864403Development of a human live attenuated West Nile infectious DNA vaccine: conceptual design of the vaccine candidate
Q61813519Differential Expression of Genes Related to Innate Immune Responses in Ex Vivo Spinal Cord and Cerebellar Slice Cultures Infected with West Nile Virus
Q27484990Differential Expression of Interferon (IFN) Regulatory Factors and IFN-Stimulated Genes at Early Times after West Nile Virus Infection of Mouse Embryo Fibroblasts
Q37376398Differential virulence and pathogenesis of West Nile viruses
Q27481032Early Production of Type I Interferon during West Nile Virus Infection: Role for Lymphoid Tissues in IRF3-Independent Interferon Production
Q30250251Epidemiological and clinical aspects on West Nile virus, a globally emerging pathogen.
Q27485316Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1
Q34428035Evidence for co-evolution of West Nile Virus and house sparrows in North America
Q39565102Evolution of attenuating mutations in dengue-2 strain S16803 PDK50 vaccine and comparison of growth kinetics with parent virus
Q66679082Evolutionary dynamics and molecular epidemiology of in New York State: 1999-2015
Q39833503Fine-scale genetic variation and evolution of West Nile Virus in a transmission "hot spot" in suburban Chicago, USA.
Q27491325Flavitrack analysis of the structure and function of West Nile non-structural proteins
Q59360247Flaviviral RNA Structures and Their Role in Replication and Immunity
Q89793960Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes
Q90798978Flavivirus infection-A review of immunopathogenesis, immunological response, and immunodiagnosis
Q38289956Flavivirus reverse genetic systems, construction techniques and applications: a historical perspective
Q43047786Formation of membrane-defined compartments by tick-borne encephalitis virus contributes to the early delay in interferon signaling.
Q42990600Generating flavivirus vaccine candidates by modulating interferon sensitivity
Q63246157Genetic and biochemical characterizations of Zika virus NS2A protein
Q35876730Genetic characterization of West Nile virus lineage 2, Greece, 2010.
Q34496125Genetic determinants of differential oral infection phenotypes of West Nile and St. Louis encephalitis viruses in Culex spp. mosquitoes
Q37673163IFN-dependent and -independent reduction in West Nile virus infectivity in human dermal fibroblasts
Q34460502IS-98-ST1 West Nile virus derived from an infectious cDNA clone retains neuroinvasiveness and neurovirulence properties of the original virus
Q38059915Immune evasion strategies of flaviviruses
Q36673924Immunopathology of flavivirus infections
Q36645530In Vitro and in Vivo Evaluation of Mutations in the NS Region of Lineage 2 West Nile Virus Associated with Neuroinvasiveness in a Mammalian Model
Q36978578Increased early RNA replication by chimeric West Nile virus W956IC leads to IPS-1-mediated activation of NF-κB and insufficient virus-mediated counteraction of the resulting canonical type I interferon signaling
Q39351015Infectious clones of novel lineage 1 and lineage 2 West Nile virus strains WNV-TX02 and WNV-Madagascar
Q40198668Inhibition of multiple strains of Venezuelan equine encephalitis virus by a pool of four short interfering RNAs
Q28950689Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses
Q38993846Innate immune escape by Dengue and West Nile viruses
Q27489865Innate immune evasion by hepatitis C virus and West Nile virus
Q33347656Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42.
Q40407813Investigation of antigen specific lymphocyte responses in healthy horses vaccinated with an inactivated West Nile virus vaccine
Q38717199Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB.
Q26699999Limited Effects of Type I Interferons on Kyasanur Forest Disease Virus in Cell Culture
Q37726746Measure and countermeasure: type I IFN (IFN-alpha/beta) antiviral response against West Nile virus
Q27025556Mechanism of West Nile virus neuroinvasion: a critical appraisal
Q27676369Membrane Topology and Function of Dengue Virus NS2A Protein
Q35154026Molecular evolution of West Nile virus in a northern temperate region: Connecticut, USA 1999-2008
Q40062309Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments
Q40154937Mutations in West Nile virus nonstructural proteins that facilitate replicon persistence in vitro attenuate virus replication in vitro and in vivo
Q27490848NS1' of Flaviviruses in the Japanese Encephalitis Virus Serogroup Is a Product of Ribosomal Frameshifting and Plays a Role in Viral Neuroinvasiveness
Q36559961Neurotropic arboviruses induce interferon regulatory factor 3-mediated neuronal responses that are cytoprotective, interferon independent, and inhibited by Western equine encephalitis virus capsid
Q47548030New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach
Q56354615PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins
Q27473291PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons
Q27477543Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion
Q92985403Phylogenetic analysis of West Nile virus in Quebec, Canada, 2004-2016: Co-circulation of distinct variants harbouring conserved amino acid motifs in North America
Q37572667Population structure of the dengue viruses, Aragua, Venezuela, 2006-2007. Insights into dengue evolution under hyperendemic transmission
Q34466812Programmed ribosomal frameshift alters expression of west nile virus genes and facilitates virus replication in birds and mosquitoes
Q27489893Progress on the development of therapeutics against West Nile virus
Q27107485RNA structures required for production of subgenomic flavivirus RNA
Q35677531Recoding of the vesicular stomatitis virus L gene by computer-aided design provides a live, attenuated vaccine candidate
Q40041785Regulation of Apoptosis during Flavivirus Infection
Q37566687Replication cycle and molecular biology of the West Nile virus
Q60031631Research advancements in the neurological presentation of flaviviruses
Q27485896Role of Nonstructural Protein NS2A in Flavivirus Assembly
Q95644980Role of pattern recognition receptors and interferon-beta in protecting bat cell lines from encephalomyocarditis virus and Japanese encephalitis virus infection
Q21090517Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism
Q35640994Scanning mutagenesis studies reveal a potential intramolecular interaction within the C-terminal half of dengue virus NS2A involved in viral RNA replication and virus assembly and secretion
Q38152910Strategies of highly pathogenic RNA viruses to block dsRNA detection by RIG-I-like receptors: hide, mask, hit.
Q34218526Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes
Q57158255Subgenomic flaviviral RNAs: What do we know after the first decade of research
Q27468655TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A
Q36523926The Interferon Type I/III Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells Can Be Attenuated or Amplified by Antiviral Treatment
Q39046949The West Nile virus assembly process evades the conserved antiviral mechanism of the interferon-induced MxA protein
Q38726766The calmodulin antagonist W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) inhibits DENV infection in Huh-7 cells.
Q39440343The generation of a reverse genetics system for Kyasanur Forest Disease Virus and the ability to antagonize the induction of the antiviral state in vitro
Q39575239The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response
Q35150808The relationship between the structure of the tick-borne encephalitis virus strains and their pathogenic properties.
Q31034150The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses
Q22809893The role of viral persistence in flavivirus biology
Q90503191Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway
Q34055431Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles
Q37006727Toll-like receptor 7 suppresses virus replication in neurons but does not affect viral pathogenesis in a mouse model of Langat virus infection
Q27477616Translation of the Flavivirus Kunjin NS3 Gene in cis but Not Its RNA Sequence or Secondary Structure Is Essential for Efficient RNA Packaging
Q34991051Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly
Q27011587Understanding the dengue viruses and progress towards their control
Q37842337Vaccines and immunotherapeutics for the prevention and treatment of infections with West Nile virus
Q26999702Vaccines in development against West Nile virus
Q41048750Variation in interferon sensitivity and induction between Usutu and West Nile (lineages 1 and 2) viruses
Q38885624Viral and Synthetic RNA Vector Technologies and Applications
Q36926779Viral stress-inducible genes.
Q34949783Virulence determinants between New York 99 and Kunjin strains of West Nile virus
Q41935743Virulence determinants of West Nile virus: how can these be used for vaccine design?
Q27488737Virus and Host Determinants of West Nile Virus Pathogenesis
Q37634452Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 receptor A, and glutamate signaling as well as flavivirus-specific upregulation of tRNA synthetases
Q27486783West Nile Virus Nonstructural Protein 1 Inhibits TLR3 Signal Transduction
Q26513109West Nile Virus Temperature Sensitivity and Avian Virulence Are Modulated by NS1-2B Polymorphisms
Q27481490West Nile Virus-Induced Neuroinflammation: Glial Infection and Capsid Protein-Mediated Neurovirulence
Q26865618West Nile Virus: biology, transmission, and human infection
Q37006746West Nile virus NS2A protein facilitates virus-induced apoptosis independently of interferon response
Q34035068West Nile virus and its emergence in the United States of America
Q38074266West Nile virus infection and immunity
Q64988889West Nile virus infection and interferon alpha treatment alter the spectrum and the levels of coding and noncoding host RNAs secreted in extracellular vesicles.
Q35943585West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response
Q35826344West Nile virus population genetics and evolution
Q51714865West Nile virus.
Q37195527West Nile virus: A re-emerging pathogen revisited
Q37876095West Nile virus: the complex biology of an emerging pathogen
Q30227143West nile virus: characteristics of an african virus adapting to the third millennium world.
Q38158918Zika Virus as an Emerging Neuropathogen: Mechanisms of Neurovirulence and Neuro-Immune Interactions
Q44169814Zika virus: what we need to know?

Search more.