Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1.

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Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E13-06-0349
P932PMC publication ID3967981
P698PubMed publication ID24501426
P5875ResearchGate publication ID260117900

P2093author name stringMaggie A Ostrowski
W James Nelson
Angela I M Barth
Kathleen A Siemers
Bertrade C Mbom
P2860cites workDelta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and functionQ22011016
Caught Nek-ing: cilia and centriolesQ24294508
beta-Catenin is a Nek2 substrate involved in centrosome separationQ24303972
Conductin/axin2 and Wnt signalling regulates centrosome cohesionQ24304045
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligaseQ24306203
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunctionQ24307199
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2Q24310473
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APCQ24336321
Rootletin forms centriole-associated filaments and functions in centrosome cohesionQ24337615
Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM componentsQ24338881
Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complexQ24532403
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin InteractionQ24551143
Re-solving the cadherin-catenin-actin conundrumQ24609734
Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindlesQ24681394
Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.Q24685871
GSK-3-selective inhibitors derived from Tyrian purple indirubinsQ27642879
Three-dimensional structure of the armadillo repeat region of beta-cateninQ27743283
The Wnt signaling pathway in development and diseaseQ27861019
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanismQ28114789
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separationQ28200983
Nek2 Localizes to Multiple Sites in Mitotic Cells, Suggesting Its Involvement in Multiple Cellular Functions during the Cell CycleQ28215182
Assembly of the cadherin-catenin complex in vitro with recombinant proteinsQ28299440
Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stabilityQ28585577
Convergence of Wnt, beta-catenin, and cadherin pathwaysQ29619504
Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesionQ30434502
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1Q30477585
The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesisQ33340686
Wnt signalling: pathway or network?Q33712586
Formation of extra centrosomal structures is dependent on β-cateninQ34098448
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.Q34575151
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancerQ34771185
The Nek2 protein kinase: a novel regulator of centrosome structureQ34818240
The Wnt signalling pathwayQ34925309
Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes.Q36012450
T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-cateninQ36333561
Structure and duplication of the centrosomeQ36860079
Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cellsQ37295489
Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradationQ39724881
A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection.Q39955472
A novel role of phospho-beta-catenin in microtubule regrowth at centrosomeQ40177769
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitinationQ40366558
Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinomaQ40385782
Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindleQ40595314
Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.Q40641191
Phosphorylation- and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases.Q40821409
The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.Q40967633
Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation.Q42439018
PCM1 Recruits Plk1 to Pericentriolar Matrix to Promote Primary Cilia Disassembly before Mitotic EntryQ42826397
Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.Q43109940
Regulation of beta-catenin structure and activity by tyrosine phosphorylation.Q43560193
Using deubiquitylating enzymes as research toolsQ46794679
Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrainQ49078794
Nek2 expression and localization in porcine oocyte during maturation.Q50719523
Regulation of E-cadherin/Catenin association by tyrosine phosphorylation.Q52537297
Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction.Q54577402
Structural and chemical characterization of isolated centrosomesQ69466305
Serine Phosphorylation-regulated Ubiquitination and Degradation of β-CateninQ73735409
Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cellsQ74130209
Proof-of-principle: oncogenic beta-catenin is a valid molecular target for the development of pharmacological inhibitorsQ78760398
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1Q79754843
P4510describes a project that usesImageJQ1659584
P433issue7
P921main subjectphosphorylationQ242736
P304page(s)977-991
P577publication date2014-02-05
P1433published inMolecular Biology of the CellQ2338259
P1476titleNek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1.
P478volume25

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cites work (P2860)
Q64270466Activation of Epithelial-Mesenchymal Transition and Altered β-Catenin Signaling in a Novel Indian Colorectal Carcinoma Cell Line
Q64111632CGK062, a small chemical molecule, inhibits cancer upregulated gene 2‑induced oncogenesis through NEK2 and β‑catenin
Q26785528Connections between cadherin-catenin proteins, spindle misorientation, and cancer
Q36289531Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate Cancer
Q37200065Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins
Q90421769Highlight article: Role of E2Fs and mitotic regulators controlled by E2Fs in the epithelial to mesenchymal transition
Q64282259Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors
Q92099394Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer
Q64971000Mechanistic Insights into Colorectal Cancer Phenomics from Fundamental and Organotypic Model Studies.
Q46237762Mitotic Regulation by NEK Kinase Networks
Q49919956Multiple oncogenic roles of nuclear beta-catenin.
Q91792599NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B/H3K4me3
Q33598631NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferation
Q34609883Nek2 is a novel regulator of B cell development and immunological response
Q64937133Nek2B activates the wnt pathway and promotes triple-negative breast cancer chemothezrapy-resistance by stabilizing β-catenin.
Q28081713New frontiers: discovering cilia-independent functions of cilia proteins
Q44052835Overexpression of the Nek2 kinase in colorectal cancer correlates with beta-catenin relocalization and shortened cancer-specific survival
Q52352270PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells
Q48134269Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk.
Q41812307Quantifying β-catenin subcellular dynamics and cyclin D1 mRNA transcription during Wnt signaling in single living cells.
Q36637143RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
Q35090475Role of NEK2A in human cancer and its therapeutic potentials.
Q48821774SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma.
Q36956969Targeting NEK2 as a promising therapeutic approach for cancer treatment
Q99728115The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis
Q39457168The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?
Q41074649WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death
Q38908764WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

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