PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells

scientific article published on June 2009

PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2174/156800909788486740
P932PMC publication ID3758122
P698PubMed publication ID19519318

P2093author name stringChuanshu Huang
Jingxia Li
Yi Huang
Chang-Yan Chen
Dongyun Zhang
Jin Ding
Beifang Ning
P2860cites workJNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Cyclin D1 in breast cancerQ28138175
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinaseQ28144326
Cyclin D1 is a nuclear protein required for cell cycle progression in G1Q28269145
Cell-cycle checkpoints and cancerQ28293996
Inorganic arsenic: a need and an opportunity to improve risk assessmentQ28768710
Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1.Q33773323
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cellsQ33854194
pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-Q33854336
Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathwayQ33884776
JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous systemQ33887876
Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathwayQ34278037
Molecular mechanisms of transformation of C3H/10T1/2 C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compoundsQ35032327
Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cellsQ35089374
United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signallingQ35139358
The interaction of glycogen synthase kinase-3 (GSK-3) with the cell cycle.Q35573746
Alterations of pRb1-cyclin D1-cdk4/6-p16(INK4A) pathway in endometrial carcinogenesisQ35606026
Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells.Q35670500
A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancerQ36134760
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cellsQ36321986
c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferationQ36376229
The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.Q36376358
PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformationQ36381304
Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in miceQ36464940
The PI3K/Akt pathway and its downstream transcriptional factors as targets for chemopreventionQ36989947
NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transitionQ39445143
Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells.Q40065920
PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1.Q40157134
Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and -independent mechanismsQ40241821
Cyclooxygenase-2 induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cellsQ40261258
Involvement of nuclear factor of activated T cells 3 (NFAT3) in cyclin D1 induction by B[a]PDE or B[a]PDE and ionizing radiation in mouse epidermal Cl 41 cellsQ40286269
Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer development and causes abnormal tissue organization and differentiationQ40302213
Effects of arsenite on cell cycle progression in a human bladder cancer cell line.Q40482372
Differential effects of JNK1 and JNK2 on signal specific induction of apoptosisQ40738775
Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicityQ40798772
Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas.Q40923302
Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cellsQ41115794
Angiotensin II activation of cyclin D1-dependent kinase activityQ41168284
Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arseniteQ42819412
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferationQ42825784
Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient miceQ46637779
Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cellsQ46875154
Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytesQ47708839
Amplification at chromosome 11q13 in transitional cell tumours of the bladder.Q53498616
Arsenite slows S phase progression via inhibition of cdc25A dual specificity phosphatase gene transcription.Q53549010
The absorption of arsenic and its relation to carcinomaQ53595252
Requirement of Erk, but not JNK, for arsenite-induced cell transformationQ63561118
The enzyme inhibitory form of inorganic arsenicQ70747589
Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cellsQ73054399
Overexpression of cyclin D1 in epithelial ovarian cancersQ73084877
Transforming growth factor-alpha enhances cyclin D1 transcription through the binding of early growth response protein to a cis-regulatory element in the cyclin D1 promoterQ73960005
Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cellsQ77419032
P433issue4
P921main subjectcell growthQ189159
P304page(s)500-509
P577publication date2009-06-01
P1433published inCurrent Cancer Drug TargetsQ332547
P1476titlePI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells
P478volume9

Reverse relations

cites work (P2860)
Q35832318By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization.
Q33765984Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells
Q30410949Glutamate transporter type 3 mediates isoflurane preconditioning-induced acute phase of neuroprotection in mice
Q35892799Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress
Q33757069Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA Stability
Q48334142Mechanism of arsenite toxicity in embryonic stem cells.
Q60960113MiR-3188 Inhibits Non-small Cell Lung Cancer Cell Proliferation Through FOXO1-Mediated mTOR-p-PI3K/AKT-c-JUN Signaling Pathway
Q30009080TGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages.
Q58571038The geranyl acetophenone tHGA attenuates human bronchial smooth muscle proliferation via inhibition of AKT phosphorylation
Q47743992The structure-activity relationship of ginsenosides on hypoxia-reoxygenation induced apoptosis of cardiomyocytes
Q34074290p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways

Search more.