EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage

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EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2147/IJN.S65990
P932PMC publication ID4134185
P698PubMed publication ID25143731

P50authorKonstantin SokolovQ50637499
P2093author name stringJack A Roth
Shinji Kuroda
Rajagopal Ramesh
Justina Tam
P2860cites workEGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyQ27824812
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpointQ28179720
Control of the G2/M transitionQ28236097
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Cancer nanotechnology: opportunities and challengesQ29615481
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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancerQ29616236
EGFR-targeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cellsQ34075391
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Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancerQ34557318
Molecular targets in cellular response to ionizing radiation and implications in space radiation protectionQ35148184
Epidermal Growth Factor Receptor Inhibitors, Gefitinib and Erlotinib (Tarceva™, OSI-774), in the Treatment of Bronchioloalveolar CarcinomaQ35575024
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Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints.Q51755718
LHRH-conjugated magnetic iron oxide nanoparticles for detection of breast cancer metastases.Q51807114
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Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticlesQ73344148
Preparation of magnetic iron oxide nanoparticles for hyperthermia of cancer in a FeCl₂-NaNO₃-NaOH aqueous systemQ83146090
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The carbohydrate specificities of the monoclonal antibodies 29.1, 455 and 3C1B12 to the epidermal growth factor receptor of A431 cellsQ38353126
EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaksQ38609721
Induction of oxidative stress, DNA damage, and apoptosis in a malignant human skin melanoma cell line after exposure to zinc oxide nanoparticles.Q39181024
Molecular imaging of p53 signal pathway in lung cancer cell cycle arrest induced by cisplatinQ39335629
DNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATM.Q39353683
Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairmentQ39462936
Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell lineQ39622406
Autophagy and oxidative stress associated with gold nanoparticlesQ39704265
Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways.Q39824343
Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3.Q40015341
Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivationQ40066410
Inhibition of nuclear factor-kappaB augments antitumor activity of adenovirus-mediated melanoma differentiation-associated gene-7 against lung cancer cells via mitogen-activated protein kinase kinase kinase 1 activationQ40146271
Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX fociQ40240295
Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activityQ40396981
Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vectorQ43556290
Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cellsQ43800235
Characterization of epidermal growth factor receptor in primary human non-small cell lung cancer.Q43927698
Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic cataQ45064006
Nanoparticle-mediated cellular response is size-dependent.Q47223945
Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties.Q47913320
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectnanoparticleQ61231
magnetite nanoparticleQ3870166
DNA damageQ5205747
magnetic nanoparticleQ117817683
P304page(s)3825-3839
P577publication date2014-08-08
P1433published inInternational Journal of NanomedicineQ6051502
P1476titleEGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage
P478volume9

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